Upregulation of BMP1 through ncRNAs correlates with adverse outcomes and immune infiltration in clear cell renal cell carcinoma

Autor: Mancheng Gong, Shengxing Feng, Dongsheng Zhou, Jinquan Luo, Tianxin Lin, Shaopeng Qiu, Runqiang Yuan, Wenjing Dong

Publikováno v: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)

Abstract Background Renal cell carcinoma (RCC) accounts for approximately 2–3% of all adult malignancies. Clear cell renal cell carcinoma (ccRCC), which comprises 70–80% of all RCC cases, is the most common histological subtype. Methods ccRCC tra

Externí odkaz: https://doaj.org/article/c5e09349d7a84ad3a347ee979c933c31

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Small-Molecule-Mediated Suppression of BMP Signaling by Selective Inhibition of BMP1-Dependent Chordin Cleavage

Autor: Takamasa Mizoguchi, Shohei Mikami, Mari Yatou, Yui Kondo, Shuhei Omaru, Shuhei Kuwabara, Wataru Okura, Syouta Noda, Takeshi Tenno, Hidekazu Hiroaki, Motoyuki Itoh

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 5, p 4313 (2023)

BMP signaling is critical for many biological processes. Therefore, small molecules that modulate BMP signaling are useful for elucidating the function of BMP signaling and treating BMP signaling-related diseases. Here, we performed a phenotypic scre

Externí odkaz: https://doaj.org/article/9b37148f20aa4cfa8d44853aca57b6be

Novel mutations in BMP1 result in a patient with autosomal recessive osteogenesis imperfecta

Autor: Lei Xi, Shanshan Lv, Hao Zhang, Zhen‐Lin Zhang

Publikováno v: Molecular Genetics & Genomic Medicine, Vol 9, Iss 6, Pp n/a-n/a (2021)

Abstract Background Osteogenesis imperfecta (OI) is a rare heritable bone disorder that is characterised by increased bone fragility and recurrent fractures. To date, only 19 OI patients have been reported, as caused by BMP1 gene mutations, worldwide

Externí odkaz: https://doaj.org/article/370f70c9991e4a068764c152bd36ecfb

Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

Autor: Katherine A.B. Kellett, Kate Fisher, Harry Aldworth, Nigel M. Hooper

Publikováno v: Kellett, K A B, Fisher, K, Aldworth, H & Hooper, N M 2023, ' Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases ', FEBS Letters . https://doi.org/10.1002/1873-3468.14667

Bone morphogenetic protein 1 (BMP1), a member of the astacin family of zinc-metalloproteases, proteolytically cleaves the low-density lipoprotein receptor (LDLR) within its ligand-binding domain, reducing the binding and cellular uptake of LDL-choles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fce982c2fbbb56f153f64aca254f879
https://doi.org/10.1002/1873-3468.14667