Zobrazeno 1 - 10
of 13
pro vyhledávání: '"BMDC, Bone marrow–derived dendritic cell"'
Autor:
Kairbaan Hodivala-Dilke, Melania Capasso, Frances R. Balkwill, Hemant M. Kocher, Michele Bombardieri, Sarah Spear, Francesca R. Delvecchio, Andrew Clear, Rachel Elizabeth Ann Fincham, Marina Roy-Luzarraga, John G. Gribben
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Cellular and Molecular Gastroenterology and Hepatology 12(5), 1543-1565 (2021). doi:10.1016/j.jcmgh.2021.06.023
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1543-1565 (2021)
Background and aims The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy. Yet, the precise role in PDAC has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbca100680dfb1efb8c0cbafa14981d0
http://europepmc.org/articles/PMC8529396
http://europepmc.org/articles/PMC8529396
Autor:
Rheinallt M. Jones, Bejan Saeedi, Richard U. Eboka, Trevor Darby, Joshua A. Owens, Crystal Naudin, Sarah Hunter-Chang, Maria E. Barbian, Lauren Askew, Brian S. Robinson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1311-1327 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims In colorectal cancer, approximately 95% of patients are refractory to immunotherapy because of low antitumor immune responses. Therefore, there is an exigent need to develop treatments that increase antitumor immune responses and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a2842f4bdfc40a2fd1a616f50f932c
https://doi.org/10.1016/j.jcmgh.2021.06.001
https://doi.org/10.1016/j.jcmgh.2021.06.001
Autor:
Andrew T. Nelson, Dionicio Siegel, Pratik Aryal, Rucha Patel, Barbara B. Kahn, Jennifer Lee, Alan Saghatelian, Ismail Syed
Publikováno v:
Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100108-(2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100108-(2021)
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with different acyl chains and multiple isomers with branch points at different car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379bcd92b776b605406c356fca084b2d
https://pubmed.ncbi.nlm.nih.gov/34418413
https://pubmed.ncbi.nlm.nih.gov/34418413
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Despite remarkable advances in medical science, infection-associated diseases remain among the leading causes of death worldwide. There is a great deal of interest and concern at the rate at which new pathogens are emerging an
Despite remarkable advances in medical science, infection-associated diseases remain among the leading causes of death worldwide. There is a great deal of interest and concern at the rate at which new pathogens are emerging an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb23dff1f01e90e977d9a7c03e1669f1
https://doi.org/10.1016/j.bcp.2018.06.009
https://doi.org/10.1016/j.bcp.2018.06.009
Publikováno v:
The Journal of Biological Chemistry
The Stimulator of Interferon Genes (STING) pathway is implicated in the innate immune response and is important in both oncogenesis and cancer treatment. Specifically, activation of the cytosolic DNA sensor STING in antigen-presenting cells (APCs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab4898a1b6a5f720572abb153606b30
https://doi.org/10.1016/j.jbc.2021.100523
https://doi.org/10.1016/j.jbc.2021.100523
Autor:
Fiona Clarke, Georgina H. Cornish, David Depoil, Harriet A. Purvis, Stephen J. Thompson, Cristina Sanchez-Blanco, Michael L. Dustin, Xuezhi Dai, David J. Rawlings, Andrew P. Cope, Rose Zamoyska
Publikováno v:
Sanchez-Blanco, C, Clarke, F, Cornish, G H, Depoil, D, Thompson, S J, Dai, X, Rawlings, D J, Dustin, M L, Zamoyska, R, Cope, A P & Purvis, H A 2018, ' Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses ', Journal of autoimmunity, vol. 94, pp. 45-55 . https://doi.org/10.1016/j.jaut.2018.07.008
Sanchez-blanco, C, Clarke, F, Cornish, G H, Depoil, D, Thompson, S J, Dai, X, Rawlings, D J, Dustin, M L, Zamoyska, R, Cope, A P & Purvis, H A 2018, ' Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses ', Journal of Autoimmunity . https://doi.org/10.1016/j.jaut.2018.07.008
Journal of Autoimmunity
Sanchez-blanco, C, Clarke, F, Cornish, G H, Depoil, D, Thompson, S J, Dai, X, Rawlings, D J, Dustin, M L, Zamoyska, R, Cope, A P & Purvis, H A 2018, ' Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses ', Journal of Autoimmunity . https://doi.org/10.1016/j.jaut.2018.07.008
Journal of Autoimmunity
A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e4f5c7f5be3be4eb3afd9a11476f9b
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Eva Gückel, Mark S. Wilson, Stephanie Czieso, Isobel S. Okoye, Andrew S. MacDonald, Victoria S. Pelly, Yanda Li, Yashaswini Kannan, Stephanie M. Coomes, Nikolay Nikolov, Lauren M. Webb, Srividya Sriskantharajah, Steven C. Ley
Publikováno v:
Kannan, Y, Li, Y, Coomes, S M, Okoye, I S, Pelly, V, Sriskantharajah, S, Gückel, E, Webb, L, Czieso, S, Nikolov, N, MacDonald, A, Ley, S C & Wilson, M S 2017, ' Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells ', Journal of Allergy and Clinical Immunology, vol. 139, no. 2 . https://doi.org/10.1016/j.jaci.2016.05.031
The Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
BACKGROUND: The molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. Tumor progression locus 2 (TPL-2) (COT, MAP3K8) kinase activates the MEK1/2-extracellular-signal regulated kinase 1/2 MAP kinase signaling p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bb032d36ffee65605f85a8574718ae
https://www.research.manchester.ac.uk/portal/en/publications/tumor-progression-locus-2-reduces-severe-allergic-airway-inflammation-by-inhibiting-ccl24-production-in-dendritic-cells(0a09f5db-2bf3-4f69-859a-08a968ec9c87).html
https://www.research.manchester.ac.uk/portal/en/publications/tumor-progression-locus-2-reduces-severe-allergic-airway-inflammation-by-inhibiting-ccl24-production-in-dendritic-cells(0a09f5db-2bf3-4f69-859a-08a968ec9c87).html
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 281-288 (2017)
Biochemistry and Biophysics Reports, Vol 9, Iss C, Pp 281-288 (2017)
Mesenchymal stem cells (MSCs) inhibit the proliferation or activation of lymphocytes, and their inhibitory effects do not require human leukocyte antigen (HLA)-matching because MSCs express low levels of HLA molecules. Therefore, MSCs may be able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51aa1ca5365c073228e749ae4484307
https://pubmed.ncbi.nlm.nih.gov/28956015
https://pubmed.ncbi.nlm.nih.gov/28956015
Autor:
David J, Dowling, Evan A, Scott, Annette, Scheid, Ilana, Bergelson, Sweta, Joshi, Carlo, Pietrasanta, Spencer, Brightman, Guzman, Sanchez-Schmitz, Simon D, Van Haren, Jana, Ninković, Dina, Kats, Cristiana, Guiducci, Alexandre, de Titta, Daniel K, Bonner, Sachiko, Hirosue, Melody A, Swartz, Jeffrey A, Hubbell, Ofer, Levy
Publikováno v:
The Journal of Allergy and Clinical Immunology
Background Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b268d92940ddeda23690f7093e59e697
https://pubmed.ncbi.nlm.nih.gov/28343701
https://pubmed.ncbi.nlm.nih.gov/28343701
Publikováno v:
Clinical Science (London, England : 1979)
Nosocomial infections represent serious complications after traumatic or surgical injuries in intensive care units. The pathogenesis of the underlying immunosuppression is only incompletely understood. In the present study, we investigated whether in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81acc6a87f4abedbc45a71dce025da44
https://pubmed.ncbi.nlm.nih.gov/25609031
https://pubmed.ncbi.nlm.nih.gov/25609031