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Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer.

Autor: Maurer HC; Department of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Garcia-Curiel A; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY., Holmstrom SR; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Castillo C; Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI., Palermo CF; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY., Sastra SA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY., Andren A; Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI., Zhang L; Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI., Le Large TYS; Department of Surgery, Amsterdam UMC, Location Vrije Universiteit, Amsterdam, Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, Netherlands., Sagalovskiy I; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Ross DR; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY., Wong W; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Shaw K; Division of GI/Endocrine Surgery, Department of Surgery, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Genkinger J; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY., Manji GA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY., Iuga AC; Department of Pathology, Columbia University Irving Medical Center, New York, NY., Schmid RM; Department of Internal Medicine II, Klinikum Rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Johnson K; University of New Hampshire, Manchester, NH., Badgley MA; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY., Lyssiotis CA; Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI., Shah Y; Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI., Califano A; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Darwin Therapeutics, New York, NY.; Chan Zuckerberg Biohub, New York, NY., Olive KP; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY.; Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY.; Columbia University Digestive and Liver Disease Research Center, Columbia University Irving Medical Center, New York, NY.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 22. Date of Electronic Publication: 2024 Jun 22.

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