Výsledky vyhledávání - "BM, bone marrow"

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

MMP9 secreted from mononuclear cell quality and quantity culture mediates STAT3 phosphorylation and fibroblast migration in wounds

Autor: Hiroko Hagiwara, Rica Tanaka, Makiko Kado, Tsubame Nishikai-Yan Shen, Satoshi Fujimura, Hiroshi Mizuno

Publikováno v: Regenerative Therapy, Vol 18, Iss, Pp 464-471 (2021)
Regenerative Therapy

Introduction Intractable ulcers may ultimately lead to amputation. To promote wound healing, researchers developed a serum-free ex vivo peripheral blood mononuclear cell quality and quantity culture (MNC-QQc) as a source for cell therapy. In mice, pi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a057ded32a7eff21e28644fa507945ee
http://www.sciencedirect.com/science/article/pii/S235232042100081X

Zobrazit plný text záznamu

Ex vivo isolation, expansion and bioengineering of CCR7+CD95-/or CD62L+CD45RA+ tumor infiltrating lymphocytes from acute myeloid leukemia patients’ bone marrow

Autor: Samiksha Wasnik, Jeffrey Xiao, Chien-Shing Chen, Do Hyun Kim, Mark E. Reeves, David J. Baylink, Ashley Howard, Olivia L. Francis, Hector Moz, Saied Mirshahidi, Huynh Cao, Yi Xu, Guido Marcucci

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1252-1260 (2021)

T cell based immunotherapies can be applicable to acute myeloid leukemia (AML). Therefore, the selection of optimal T cells, cell manufacturing, and therapeutic T cell engineering are essential for the development of effective adoptive T cell therapi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8631938224952c24db64ba170babb9e6
http://europepmc.org/articles/PMC8603025

Zobrazit plný text záznamu

Programmed Death Ligand 1-Expressing Classical Dendritic Cells Mitigate Helicobacter -Induced Gastritis

Autor: Go, Du-Min, Lee, Seung Hyun, Lee, Su-Hyung, Woo, Sang-Ho, Kim, Kibyeong, Kim, Kyeongdae, Park, Kyu Seong, Park, Jong-Hwan, Ha, Sang-Jun, Kim, Woo Ho, Choi, Jae-Hoon, Kim, Dae-Yong

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Helicobacter pylori has been reported to modulate local immune responses to colonize persistently in gastric mucosa. Although the induced expression of programmed cell death ligand 1 (PD-L1) has been suggested as an immune modulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef8f6fcf149fca0f5b3eb28847252f65
http://europepmc.org/articles/PMC8267570

Zobrazit plný text záznamu

Helicobacter pylori–Induced Rev-erbα Fosters Gastric Bacteria Colonization by Impairing Host Innate and Adaptive Defense

Autor: Rui Xie, Jingyu Xu, Yong-sheng Teng, Chuan-jie Hao, Shi-Ming Yang, Weisan Chen, Tao Liu, Yi-pin Lv, Yuan Zhuang, Quanming Zou, Fang-yuan Mao, Ping Cheng, Yu-gang Liu

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 395-425 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Rev-erbα represents a powerful transcriptional repressor involved in immunity. However, the regulation, function, and clinical relevance of Rev-erbα in Helicobacter pylori infection are presently unknown. Methods Rev-erbα was exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1709675849435bdb7635457d1ff336db
https://doi.org/10.1016/j.jcmgh.2021.02.013

Zobrazit plný text záznamu

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells

Autor: Dushyantha Jayaweera, Aisha Khan, Xian Ming Chu, Huilan Wang, Michael A. Bellio, Andrea da Fonseca Ferreira, Chunming Dong, Lukun Zhang, Qianhuan Zhang, Joshua M. Hare, Jianqing Wei, Liyong Wang

Publikováno v: JACC: Basic to Translational Science

Visual Abstract
Highlights • EVs derived from young, but not aged, MSCs rejuvenate senescent EPCs in vitro, recapitulating the effect of MSC transplantation. • Aged MSCs can be genetically modified to produce tailored EVs with increased EPC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2afc19ee994840a31f2daf0844a791
http://europepmc.org/articles/PMC7691285

Zobrazit plný text záznamu

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

Autor: Gail A. Van Norman

Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 7, Pp 845-854 (2019)
JACC: Basic to Translational Science

Summary: Animal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor predictors of drug safety in humans. The cost of animal research is high—in dollars, delays i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8176f0152ffdf0d9a595ade8d09f4734
https://doi.org/10.1016/j.jacbts.2020.03.010

Zobrazit plný text záznamu

Is Avoiding Stem Cell Exhaustion the New Therapeutic Approach in Colitis?

Autor: Anisa Shaker

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1204-1206 (2021)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Histidine decarboxylase (HDC), the histamine-synthesizing enzyme, is expressed in a subset of myeloid cells but also marks quiescent myeloid-biased hematopoietic stem cells (MB-HSCs) that are activated upon myeloid demand injury. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7e2d6f725474d357ecdeaa0aacf2e2
http://www.sciencedirect.com/science/article/pii/S2352345X20302009

Zobrazit plný text záznamu

TWEAK/Fn14 Is Overexpressed in Crohn’s Disease and Mediates Experimental Ileitis by Regulating Critical Innate and Adaptive Immune Pathways

Autor: Theresa T. Pizarro, Luca Di Martino, Abdullah Osme, Sarah Kossak-Gupta, Fabio Cominelli

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 427-446 (2019)

Background & Aims Crohn’s disease (CD) is a debilitating inflammatory disorder that affects more than 1.6 million people in North America alone. Members of the tumor necrosis factor superfamily are key regulators of intestinal inflammation; specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0702fefa38e044953321dee937f8d92f
http://europepmc.org/articles/PMC6718944

Zobrazit plný text záznamu

Ets1 Plays a Critical Role in MLL/EB1-Mediated Leukemic Transformation in a Mouse Bone Marrow Transplantation Model

Autor: Ying-Jung Huang, Jen-Fen Fu, Tzung-Hai Yen, Lee-Yung Shih

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 5, Pp 469-481 (2019)
Neoplasia (New York, N.Y.)

Leukemogenic potential of MLL fusion with the coiled-coil domain-containing partner genes and the downstream target genes of this type of MLL fusion have not been clearly investigated. In this study, we demonstrated that the coiled-coil–four-helix

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae6e39f4ce6499022a02bece2ea557b
http://www.sciencedirect.com/science/article/pii/S1476558619300090

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání