Immune landscape after allo-HSCT: TIGIT- and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse

Autor: Viviane Gournay, Nicolas Vallet, Vivien Peux, Kristi Vera, Jennifer Bordenave, Marion Lambert, Aurélien Corneau, David Michonneau, Régis Peffault de Latour, Sophie Caillat-Zucman, Gérard Socié, Mathieu F. Chevalier

Publikováno v: Blood
Blood, American Society of Hematology, In press, ⟨10.1182/blood.2022015522⟩

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective treatment for selected patients with acute myeloid leukemia (AML) and relies on a “graft-versus-leukemia” effect (GVL) where donor T lymphocytes mediate control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf71c0df8cc0a276d3757aed4c6af6b7
https://doi.org/10.1182/blood.2022015522

Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels

Autor: Christopher J. Ng, Alice Liu, Sujatha Venkataraman, Katrina J. Ashworth, Christopher D. Baker, Rebecca O’Rourke, Rajeev Vibhakar, Kenneth L. Jones, Jorge Di Paola

Publikováno v: Blood

von Willebrand factor (VWF) plays a key role in normal hemostasis, and deficiencies of VWF lead to clinically significant bleeding. We sought to identify novel modifiers of VWF levels in endothelial colony-forming cells (ECFCs) using single-cell RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d39d0068664165259dd868e541d8ee
https://doi.org/10.1182/blood.2021010683

Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma

Autor: Leo Meriranta, Amjad Alkodsi, Annika Pasanen, Maija Lepistö, Parisa Mapar, Yngvild Nuvin Blaker, Judit Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Idun Fiskvik, Lars Tore G. Mikalsen, Matias Autio, Magnus Björkholm, Mats Jerkeman, Øystein Fluge, Peter Brown, Sirkku Jyrkkiö, Harald Holte, Esa Pitkänen, Pekka Ellonen, Sirpa Leppä

Publikováno v: Blood
Meriranta, L, Alkodsi, A, Pasanen, A, Lepistö, M, Mapar, P, Blaker, Y N, Jørgensen, J M, Karjalainen-Lindsberg, M-L, Fiskvik, I, Mikalsen, L T G, Autio, M, Björkholm, M, Jerkeman, M, Fluge, Ø, Brown, P, Jyrkkiö, S, Holte, H, Pitkänen, E, Ellonen, P & Leppa, S 2022, ' Molecular features encoded in the ctDNA reveal heterogeneity and predict outcome in high-risk aggressive B-cell lymphoma ', Blood, vol. 139, no. 12, pp. 1863-1877 . https://doi.org/10.1182/blood.2021012852

Inadequate molecular and clinical stratification of the patients with high-risk diffuse large B-cell lymphoma (DLBCL) is a clinical challenge hampering the establishment of personalized therapeutic options. We studied the translational significance o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a8922736ebf9763275c471d8a04f16
https://doi.org/10.1182/blood.2021012852

Nonhuman glycans can regulate anti–factor VIII antibody formation in mice

Autor: Sooncheon Shin, Jianmei Wang, Christopher B. Doering, Shannon L. Meeks, Xeuzheng Song, Patricia E Zerra, Sean R. Stowell, Connie M. Arthur, Pete Lollar

Publikováno v: Blood

Recombinant factor VIII (FVIII) products represent a life-saving intervention for patients with hemophilia A. However, patients can develop antibodies against FVIII that prevent its function and directly increase morbidity and mortality. The developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bf6b47d73bbe87533e16ce5f4ec4dc
https://doi.org/10.1182/blood.2020009210

Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules

Autor: Andrea L. Ambrosio, Hallie P. Febvre, Santiago M. Di Pietro

Publikováno v: Blood

Platelet α-granules regulate hemostasis and myriad other physiological processes, but their biogenesis is unclear. Mutations in only 3 proteins are known to cause α-granule defects and bleeding disorders in humans. Two such proteins, VPS16B and VPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1399643ba50e71ddbf8269925729e781
https://doi.org/10.1182/blood.2021012056