O20 Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children

Autor: W Maruszak, Ehj Krekels, Mark A. Turner, W.H.J. Vaes, BD van Groen, E van Duijn, L-T Kõrgvee, RC Garner, C. A. J. Knibbe, SN de Wildt, Dick Tibboel, BK Park, Grzegorz Grynkiewicz

Publikováno v: Archives of Disease in Childhood. 104:e9.1-e9

BackgroundDrug disposition in children may vary from adults due to age-related variation in drug metabolism, but paediatric pharmacokinetic (PK) studies are challenging. Microdose studies present an innovation to study PK in paediatrics, and can only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cca66ce06848f3ccdd8da5de9d1604e2
https://doi.org/10.1136/archdischild-2019-esdppp.20

Pediatric Microdose and Microtracer Studies Using C-14 in Europe

Autor: RC Garner, Albert D. Windhorst, Grzegorz Grynkiewicz, W.H.J. Vaes, Dick Tibboel, N. H. Hendrikse, BK Park, Lenne-Triin Kõrgvee, W Maruszak, SN de Wildt, Mark A. Turner, M. G. Mooij, C. A. J. Knibbe

Publikováno v: Turner, M, Mooij, M, Vaes, W, Windhorst, A D, Hendrikse, N H, Knibbe, C, Korgvee, L, Maruszak, W, Grynkiewicz, G, Garner, R, Tibboel, D, Park, B & de Wildt, S 2015, ' Pediatric Microdose and Microtracer Studies Using C-14 in Europe ', Clinical Pharmacology & Therapeutics, vol. 98, no. 3, pp. 234-237 . https://doi.org/10.1002/cpt.163
Clinical Pharmacology & Therapeutics, 98(3), 234-237. Wiley-Blackwell

Important information gaps remain on the efficacy and safety of drugs in children. Pediatric drug development encounters several ethical, practical, and scientific challenges. One barrier to the evaluation of medicines for children is a lack of innov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02bc2435c9bbb72412ef41138f6c573
https://research.vumc.nl/en/publications/05c26eef-5892-417a-80cd-1a10243f51ca

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system

Autor: Fj, Vilar, Dj, Naisbitt, Bk, Park, Munir Pirmohamed

Publikováno v: Europe PubMed Central

Drug hypersensitivity is a major problem in HIV medicine. These reactions limit the choice of antiretrovirals that can be used in a patient and, at times, can lead to failure to administer an adequate regimen. Hypersensitivity reactions occur in a mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::35c3de9c753c96264c7843e41f591a46
https://pubmed.ncbi.nlm.nih.gov/12838164

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat

Autor: Hj, Gill, Sj, Hough, Dj, Naisbitt, Jl, Maggs, Nr, Kitteringham, Munir Pirmohamed, Bk, Park

Publikováno v: Europe PubMed Central

Idiosyncratic toxicity associated with sulfamethoxazole (SMX) is thought to be a consequence of bioactivation to the hydroxylamine metabolite (SMX-NOH) and further oxidation to the ultimate reactive metabolite, nitroso-sulfamethoxazole (SMX-NO). To e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::37e0327dcbdfe441d9bc762131cfbbd8
https://pubmed.ncbi.nlm.nih.gov/9262343

Induction of mixed function oxidase activity in man by rifapentine (MDL 473), a long-acting rifamycin derivative

Autor: Caroline E. Hampden, BK Park, Alan R. Boobis, D Vital Durand, Donald S. Davies

Publikováno v: British Journal of Clinical Pharmacology. 21:1-7

The effects of rifapentine (MDL 473) administration on hepatic mixed function oxidase activity in man have been investigated in six healthy volunteers. Administration of rifapentine (600 mg 48 h-1) for 10 days resulted in a significant reduction in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb2b60028007ca1699a40e24306155b
https://doi.org/10.1111/j.1365-2125.1986.tb02816.x