Zobrazeno 1 - 10
of 2 724
pro vyhledávání: '"BINDING KINETICS"'
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn). While prior research has mainly investigated
Externí odkaz:
https://doaj.org/article/8e21d7845285420f8c4d1cd91773b5b4
Autor:
Johannes Reusch, Linda Elise Franken, Jakob Then, Philippe Ringler, Joachim Butzer, Thomas Juroschek, Christian Klein, Tilman Schlothauer, Laurent Larivière
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
TRIM21 is a pivotal effector in the immune system, orchestrating antibody-mediated responses and modulating immune signaling. In this comprehensive study, we focus on the interaction of TRIM21 with Fc engineered antibodies and subsequent implications
Externí odkaz:
https://doaj.org/article/152da4a7b8dd4fd591df1938822e36c4
Autor:
Irene Istúriz Petitjean, Quang D. Tran, Angeliki Goutou, Zima Kabir, Gerhard Wiche, Cécile Leduc, Gijsje H. Koenderink
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151403- (2024)
Cell shape and motility are determined by the cytoskeleton, an interpenetrating network of actin filaments, microtubules, and intermediate filaments. The biophysical properties of each filament type individually have been studied extensively by cell-
Externí odkaz:
https://doaj.org/article/62c7d5d348ff4e7cae7ba64056e64e0e
Autor:
Siim Kukk
Publikováno v:
Proceedings of the Estonian Academy of Sciences, Vol 72, Iss 4, Pp 402-406 (2023)
Kinetic analysis of the interaction of four NÂsubstituted nortropane derivatives with the dopamine transporter was made to characterize the mechanism of the binding process. The kinetics were studied by radioligand binding experiments. It was foun
Externí odkaz:
https://doaj.org/article/614bc2c99d174b57b3623fad40ffa10a
Autor:
Roswitha Dolcemascolo, María Heras-Hernández, Lucas Goiriz, Roser Montagud-Martínez, Alejandro Requena-Menéndez, Raúl Ruiz, Anna Pérez-Ràfols, R Anahí Higuera-Rodríguez, Guillermo Pérez-Ropero, Wim F Vranken, Tommaso Martelli, Wolfgang Kaiser, Jos Buijs, Guillermo Rodrigo
Publikováno v:
eLife, Vol 12 (2024)
The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles. Here, we engineered an orthogona
Externí odkaz:
https://doaj.org/article/2f7dd1c6b8fa456f82d0226daa76c65a
Publikováno v:
Smart Molecules, Vol 1, Iss 3, Pp n/a-n/a (2023)
Abstract Binding kinetic properties of protein–ligand complexes are crucial factors affecting the drug potency. Nevertheless, the current in silico techniques are insufficient in providing accurate and robust predictions for binding kinetic propert
Externí odkaz:
https://doaj.org/article/b006dc2af2c7436b840b4acdcc11f4d0
Autor:
Kumar Tekwani Movellan, Melanie Wegstroth, Kerstin Overkamp, Andrei Leonov, Stefan Becker, Loren B. Andreas
Publikováno v:
Journal of Structural Biology: X, Vol 8, Iss , Pp 100090- (2023)
The drug Rimantadine binds to two different sites in the M2 protein from influenza A, a peripheral site and a pore site that is the primary site of efficacy. It remained enigmatic that pore binding did not occur in certain detergent micelles, and in
Externí odkaz:
https://doaj.org/article/6126c5d4268f427484adf5d7d99bc435
Autor:
Paul, Fabian1,2 fabian.paul@mpikg.mpg.de, Weikl, Thomas R.1 thomas.weikl@mpikg.mpg.de
Publikováno v:
PLoS Computational Biology. 9/16/2016, Vol. 12 Issue 9, p1-17. 17p. 4 Graphs.
Publikováno v:
Eng, Vol 4, Iss 1, Pp 367-379 (2023)
In the quest for the development of accurate, reliable, and cost-effective biosensing technology for early diagnostics of prostate cancer, we describe here an electrochemical biosensor combining a simple transducing method of differential pulse volta
Externí odkaz:
https://doaj.org/article/55659d9332874d5db30ec30e1b04a0e9
Autor:
Mensonides, Femke I. C.1, Brul, Stanley2, Hellingwerf, Klaas J.1, Bakker, Barbara M.3, Teixeira de Mattos, M. Joost1
Publikováno v:
FEBS Journal. Feb2014, Vol. 281 Issue 3, p825-841. 17p.