Increased levels of a mycophenolic acid metabolite in patients with kidney failure negatively affect cardiomyocyte health.

Autor: Harlacher E; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Schulte C; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Vondenhoff S; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Schmitt-Kopplin P; Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.; Analytical Food Chemistry, Technical University of Munich, Freising, Germany., Diederich P; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Hemmers C; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Moellmann J; Department of Internal Medicine I, Cardiology, University Hospital RWTH Aachen, Aachen, Germany., Wollenhaupt J; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Veltrop R; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Biessen E; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), RWTH Aachen Campus, Aachen, Germany., Lehrke M; Department of Internal Medicine I, Cardiology, University Hospital RWTH Aachen, Aachen, Germany., Peters B; Department of Nephrology, Skaraborg Hospital, Skövde, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Schlieper G; Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany., Kuppe C; Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany., Floege J; Department of Internal Medicine I, Cardiology, University Hospital RWTH Aachen, Aachen, Germany.; Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany., Jankowski V; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany., Marx N; Department of Internal Medicine I, Cardiology, University Hospital RWTH Aachen, Aachen, Germany.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), RWTH Aachen Campus, Aachen, Germany., Jankowski J; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany.; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), RWTH Aachen Campus, Aachen, Germany., Noels H; Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.; University Hospital RWTH Aachen, Aachen, Germany.; Aachen-Maastricht Institute for Cardiorenal Disease (AMICARE), RWTH Aachen Campus, Aachen, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Mar 06; Vol. 11, pp. 1346475. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024).

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LifeTime and improving European healthcare through cell-based interceptive medicine

Autor: Rajewsky, N., Almouzni, G., Gorski, S., Aerts, S., Amit, I., Bertero, M., Bock, C., Bredenoord, A., Cavalli, G., Chiocca, S., Clevers, H., Strooper, B., Eggert, A., Ellenberg, J., Fernández, X., Figlerowicz, M., Gasser, S., Hubner, N., Kjems, J., Knoblich, J., Krabbe, G., Lichter, P., Linnarsson, S., Marine, J., Marioni, J., Marti-Renom, M., Netea, M., Nickel, D., Nollmann, M., Novak, H., Parkinson, H., Piccolo, S., Pinheiro, I., Pombo, A., Popp, C., Reik, W., Roman-Roman, S., Rosenstiel, P., Schultze, J., Stegle, O., Tanay, A., Testa, G., Thanos, D., Theis, F., Torres-Padilla, M., Valencia, A., Vallot, C., van Oudenaarden, A., Vidal, M., Voet, T., Alberi, L., Alexander, S., Alexandrov, T., Arenas, E., Bagni, C., Balderas, R., Bandelli, A., Becher, B., Becker, M., Beerenwinkel, N., Benkirame, M., Beyer, M., Bickmore, W., Biessen, E., Blomberg, N., Blumcke, I., Bodenmiller, B., Borroni, B., Boumpas, D., Bourgeron, T., Bowers, S., Braeken, D., Brooksbank, C., Brose, N., Bruining, H., Bury, J., Caporale, N., Cattoretti, G., Chabane, N., Chneiweiss, H., Cook, S., Curatolo, P., de Jonge, M., Deplancke, B., de Witte, P., Dimmeler, S., Draganski, B., Drews, A., Dumbrava, C., Engelhardt, S., Gasser, T., Giamarellos-Bourboulis, E., Graff, C., Grün, D., Gut, I., Hansson, O., Henshall, D., Herland, A., Heutink, P., Heymans, S., Heyn, H., Huch, M., Huitinga, I., Jackowiak, P., Jongsma, K., Journot, L., Junker, J., Katz, S., Kehren, J., Kempa, S., Kirchhof, P., Klein, C., Koralewska, N., Korbel, J., Kühnemund, M., Lamond, A., Lauwers, E., Le Ber, I., Leinonen, V., Tobon, A., Lundberg, E., Lunkes, A., Maatz, H., Mann, M., Marelli, L., Matser, V., Matthews, P., Mechta-Grigoriou, F., Menon, R., Nielsen, A., Pagani, M., Pasterkamp, R., Pitkänen, A., Popescu, V., Pottier, C., Puisieux, A., Rademakers, R., Reiling, D., Reiner, O., Remondini, D., Ritchie, C., Rohrer, J., Saliba, A., Sanchez-Valle, R., Santosuosso, A., Sauter, A., Scheltema, R., Scheltens, P., Schiller, H., Schneider, A., Seibler, P., Sheehan-Rooney, K., Shields, D., Sleegers, K., Smit, A., Smith, K., Smolders, I., Synofzik, M., Tam, W., Teichmann, S., Thom, M., Turco, M., van Beusekom, H., Vandenberghe, R., den Hoecke, S., de Poel, I., van der Ven, A., van der Zee, J., van Lunzen, J., van Minnebruggen, G., Paesschen, W., van Swieten, J., van Vught, R., Verhage, M., Verstreken, P., Villa, C., Vogel, J., von Kalle, C., Walter, J., Weckhuysen, S., Weichert, W., Wood, L., Ziegler, A., Zipp, F.

Publikováno v: Nature
England
Nature, 587(7834), 377-386. Nature Publishing Group
Nature 587, 377–386 (2020)
Nature, Nature Publishing Group, 2020, 587 (7834), pp.377-386. ⟨10.1038/s41586-020-2715-9⟩
Nature, 587. Nature Research
Rajewsky, N, Almouzni, G, Gorski, S A, Aerts, S, Amit, I, Bertero, M G, Bock, C, Bredenoord, A L, Cavalli, G, Chiocca, S, Clevers, H, De Strooper, B, Eggert, A, Ellenberg, J, Fernández, X M, Figlerowicz, M, Gasser, S M, Hubner, N, Kjems, J, Knoblich, J A, Krabbe, G, Lichter, P, Linnarsson, S, Marine, J C, Marioni, J C, Marti-Renom, M A, Netea, M G, Nickel, D, Nollmann, M, Novak, H R, Parkinson, H, Piccolo, S, Pinheiro, I, Pombo, A, Popp, C, Reik, W, Roman-Roman, S, Rosenstiel, P, Schultze, J L, Stegle, O, Tanay, A, Testa, G, Thanos, D, Theis, F J, Torres-Padilla, M E, Valencia, A, Vallot, C, van Oudenaarden, A, Vidal, M, Voet, T & LifeTime Community Working Groups 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
Nature, 587, 377-386
Nature, 587, 7834, pp. 377-386
Nature 587(7834), 377-386 (2020). doi:10.1038/s41586-020-2715-9
LifeTime Community Working Groups 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, no. 7834, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Rajewsky, N, Almouzni, G, Gorski, S A, Aerts, S, Amit, I, Bertero, M G, Bock, C, Bredenoord, A L, Cavalli, G, Chiocca, S, Clevers, H, de Strooper, B, Eggert, A, Ellenberg, J, Fernández, X M, Figlerowicz, M, Gasser, S M, Hubner, N, Kjems, J R, Knoblich, J R A, Krabbe, G, Lichter, P, Linnarsson, S, Marine, J-C, Marioni, J, Marti-Renom, M A, Netea, M G, Nickel, D R, Nollmann, M, Novak, H R, Parkinson, H, Piccolo, S, Pinheiro, I, Pombo, A, Popp, C, Reik, W, Roman-Roman, S, Rosenstiel, P, Schultze, J L, Stegle, O, Tanay, A, Testa, G, Thanos, D, Theis, F J, Torres-Padilla, M-E, Valencia, A, Vallot, C L, van Oudenaarden, A, Vidal, M, Voet, T & LifeTime Community 2020, ' LifeTime and improving European healthcare through cell-based interceptive medicine ', Nature, vol. 587, no. 7834, pp. 377-386 . https://doi.org/10.1038/s41586-020-2715-9
Nature, 587 (7834)
Nature: international weekly journal of science, 587(7834)

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemente

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa83a48c0915b263383b56fe48dbb757
https://hdl.handle.net/10033/622882

Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol

Autor: Van Kuijk, K., Mccracken, I., Tillie, R., Asselberghs, S., Kheder, D., Muitjens, S., Jin, H., Taylor, R., Schreur, R. Wichers, Kuppe, C., Dobie, R., Ramachandran, P., Gijbels, M., Temmerman, L., Kirkwood, P., Luyten, J., Li, Y., Noels, H., Goossens, P., Wilson-Kanamori, J., Schurgers, L., Shen, Y., Mees, B., Biessen, E., Henderson, N., Kramann, R., Baker, A., Sluimer, J.

Publikováno v: In Atherosclerosis August 2023 379 Supplement 1:S28-S28

Microrna-26B as novel regulator of cardio-metabolic diseases

Autor: Peters, L., Bidzhekov, K., Rakateli, L., Jans, A., Maas, S., Gijbels, M., Jankowski, J., Döring, Y., Biessen, E., Houben, T., Bartneck, M., Van Der Vorst, E.

Publikováno v: In Atherosclerosis August 2023 379 Supplement 1:S2-S2