Preclinical assessment for translation to humans: The PATH approach for assessing supporting evidence for early-phase trials and innovative care.

Autor: Kimmelman J; Department of Equity, Ethics and Policy, Rm 1155, School of Population and Global Health, McGill University, 2001 McGill College, Montreal, QC H3A 1L7, Canada. Electronic address: jonathan.kimmelman@mcgill.ca., Bodilly Kane P; Department of Equity, Ethics and Policy, Rm 1155, School of Population and Global Health, McGill University, 2001 McGill College, Montreal, QC H3A 1L7, Canada., Bicer S; Department of Equity, Ethics and Policy, Rm 1155, School of Population and Global Health, McGill University, 2001 McGill College, Montreal, QC H3A 1L7, Canada., Carlisle BG; Department of Equity, Ethics and Policy, Rm 1155, School of Population and Global Health, McGill University, 2001 McGill College, Montreal, QC H3A 1L7, Canada.

Publikováno v: Med (New York, N.Y.) [Med] 2024 Oct 11; Vol. 5 (10), pp. 1227-1236. Date of Electronic Publication: 2024 Aug 07.

Investigating cryopreserved PBMC functionality in an antigen-induced model of sarcoidosis granuloma formation.

Autor: Seman SG; Biomedical Engineering Department, The Ohio State University College of Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: seman.40@osu.edu., Bicer S; Biomedical Engineering Department, The Ohio State University College of Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: bicer.1@osu.edu., Julian MW; Division of Pulmonary, Critical Care and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: mark.julian@osumc.edu., Mitchell JR; Biomedical Engineering Department, The Ohio State University College of Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: mitchell.1714@osu.edu., Kramer PJ; Division of Pulmonary, Critical Care and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: patrick.kramer@osumc.edu., Crouser ED; Division of Pulmonary, Critical Care and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: elliott.crouser@osumc.edu., Locke LW; Biomedical Engineering Department, The Ohio State University College of Engineering, The Ohio State University, Columbus, OH, USA. Electronic address: locke.51@osu.edu.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Jun 25; Vol. 714, pp. 149993. Date of Electronic Publication: 2024 Apr 23.

Timing for First-in-Minor Clinical Trials of New Cancer Drugs.

Autor: Bicer S; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada., Hutchinson N; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada., Feldhake E; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada., Nelson A; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada., Oliviero E; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada., Waligóra M; Research Ethics in Medicine Study Group (REMEDY), Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland., Kimmelman J; Studies of Translation, Ethics and Medicine, Department of Equity, Ethics and Policy, McGill University, Montreal, QC, Canada. Electronic address: jonathan.kimmelman@mcgill.ca.

Publikováno v: The Journal of pediatrics [J Pediatr] 2023 Dec; Vol. 263, pp. 113705. Date of Electronic Publication: 2023 Aug 31.

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Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment.

Autor: Offman E; Certara, Princeton, NJ, United States., Singh N; Xentria, Inc., Chicago, IL, United States., Julian MW; Division of Pulmonary, Critical Care and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United States., Locke LW; Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, United States.; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States., Bicer S; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States., Mitchell J; Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States., Matthews T; Xentria, Inc., Chicago, IL, United States., Anderson K; Xentria, Inc., Chicago, IL, United States., Crouser ED; Division of Pulmonary, Critical Care and Sleep Medicine, The Dorothy M. Davis Heart and Lung Research Institute, Columbus, OH, United States.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2023 Mar 20; Vol. 14, pp. 1066454. Date of Electronic Publication: 2023 Mar 20 (Print Publication: 2023).