Výsledky vyhledávání - "BHI, brain heart infusion"

Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

Autor: Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10ca45cdbb87dcf2ef29e5865d5f864
https://doi.org/10.1016/j.apsb.2020.12.021

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When Pathobiont-Carbohydrate Interaction Turns Bittersweet!

Autor: Nicolas Barnich, Benoit Chassaing

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, 2021, 12 (4), pp.1509-1510. ⟨10.1016/j.jcmgh.2021.08.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1509-1510 (2021)

Background & Aims The inflammatory bowel diseases (IBDs), Crohn’s disease and ulcerative colitis, are caused in part by aberrant immune responses to resident intestinal bacteria. Certain dietary components, including carbohydrates, are associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3471e2ad1f53d2487af964f73832ffad
https://pubmed.ncbi.nlm.nih.gov/34246809

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Bile acid-receptor TGR5 deficiency worsens liver injury in alcohol-fed mice by inducing intestinal microbiota dysbiosis

Autor: Spatz, Madeleine, Ciocan, Dragos, Merlen, Gregory, Rainteau, Dominique, Humbert, Lydie, Gomes-Rochette, Neuza, Hugot, Cindy, Trainel, Nicolas, Mercier-Nomé, Françoise, Domenichini, Séverine, Puchois, Virginie, Wrzosek, Laura, Ferrere, Gladys, Tordjmann, Thierry, Perlemuter, Gabriel, Cassard, Anne-Marie

Publikováno v: JHEP Reports, Vol 3, Iss 2, Pp 100230-(2021)
JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100230. ⟨10.1016/j.jhepr.2021.100230⟩
JHEP Reports

Background & Aims Bile-acid metabolism and the intestinal microbiota are impaired in alcohol-related liver disease. Activation of the bile-acid receptor TGR5 (or GPBAR1) controls both biliary homeostasis and inflammatory processes. We examined the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae520b76500b6b211e8c427c2e781d78
http://www.sciencedirect.com/science/article/pii/S2589555921000069

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Complete genome for Actinobacillus pleuropneumoniae serovar 8 reference strain 405 : comparative analysis with draft genomes for different laboratory stock cultures indicates little genetic variation

Publikováno v: Microbial Genomics 7 (2021) 11
Bossé, Janine T; Li, Yanwen; Cohen, Liza Miriam; Stegger, Marc; Angen, Øystein; Lacouture, Sonia; Gottschalk, Marcelo; Lei, Liancheng; Koene, Miriam; Kuhnert, Peter; Bandara, Aloka B; Inzana, Thomas J; Holden, Matthew T G; Harris, David; Oshota, Olusegun; Maskell, Duncan J; Tucker, Alexander W; Wren, Brendan W; Rycroft, Andrew N and Langford, Paul R (2021). Complete genome for Actinobacillus pleuropneumoniae serovar 8 reference strain 405: comparative analysis with draft genomes for different laboratory stock cultures indicates little genetic variation. Microbial genomics, 7(11) Microbiology Society 10.1099/mgen.0.000687
Microbial Genomics
Microbial Genomics, 7(11)

This work was supported by a Longer and Larger (LoLa) grant from the Biotechnology and Biological Sciences Research Council (grant numbers BB/G020744/1, BB/G019177/1, BB/G019274/1, BB/G018553/1, BB/S002103/1, and BB/S005897/1), the UK Department for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db78d5fef3d73a5378acda4b6ae5b1a
https://research.wur.nl/en/publications/complete-genome-for-actinobacillus-pleuropneumoniae-serovar-8-ref

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The multidomain architecture of a bacteriophage endolysin enables intramolecular synergism and regulation of bacterial lysis

Autor: Philippe Moreillon, Carmen Menzi, Frank Oechslin, Grégory Resch

Publikováno v: The Journal of Biological Chemistry
The Journal of biological chemistry, vol. 296, pp. 100639

Endolysins are peptidoglycan hydrolases produced at the end of the bacteriophage (phage) replication cycle to lyse the host cell. Endolysins in Gram-positive phages come in a variety of multimodular forms that combine different catalytic and cell wal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24dbb612b488ac79661b29c64ee8caa
https://pubmed.ncbi.nlm.nih.gov/33838182

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Immunoglobulin isotype isolated from human placental extract does not interfere in complement‐mediated bacterial opsonization within the wound milieu

Autor: Kanika Sharma, Debasish Bhattacharyya

Publikováno v: FEBS Open Bio, Vol 5, Iss 1, Pp 369-377 (2015)
FEBS Open Bio

Highlights • Human placental extract has many applications as a wound healer. • Immunoglobulin G is a key glycoprotein present in human placental extract. • Placental IgG (25.2 ± 3.97 μg/ml) did not exert anti-complementary effects.
The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932d855c37ddb1496ba1357a9644ee28
https://doaj.org/article/c22023f85cff41d0a2611c505a6523b9

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