Zobrazeno 1 - 10
of 173
pro vyhledávání: '"BH3-mimetics"'
Autor:
Florian Daressy, Line Séguy, Loëtitia Favre, Sophie Corvaisier, Cécile Apel, Anne-Claire Groo, Marc Litaudon, Vincent Dumontet, Aurélie Malzert-Fréon, Sandy Desrat, Fanny Roussi, Aude Robert, Joëlle Wiels
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 154, Iss , Pp 113546- (2022)
The overexpression of antiapoptotic members (BCL-2, BCL-xL, MCL-1, etc.) of the BCL-2 family contributes to tumor development and resistance to chemotherapy or radiotherapy. Synthetic inhibitors targeting these proteins have been developed, and some
Externí odkaz:
https://doaj.org/article/42554ec0867d47a2bab1e7e9b84fdb89
Akademický článek
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Autor:
Marlen Michalski, Magdalena Bauer, Franziska Walz, Deniz Tümen, Philipp Heumann, Petra Stöckert, Manuela Gunckel, Claudia Kunst, Arne Kandulski, Stephan Schmid, Martina Müller, Karsten Gülow
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1666 (2023)
Despite the recent approval of new therapies, the prognosis for patients with hepatocellular carcinoma (HCC) remains poor. There is a clinical need for new highly effective therapeutic options. Here, we present a combined application of BH3-mimetics
Externí odkaz:
https://doaj.org/article/32cdf933719441d7bc376b5845017e2c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4708 (2023)
Myelodysplastic syndromes (MDSs) belong to a group of clonal bone marrow malignancies. In light of the emergence of new molecules, a significant contribution to the understanding of the pathogenesis of the disease is the study of the B-cell CLL/lymph
Externí odkaz:
https://doaj.org/article/96cca9f2ebe04c408b4fddeb3f332543
Publikováno v:
Cells, Vol 12, Iss 5, p 800 (2023)
Evasion of apoptosis is one of the hallmarks of cancer cells. Proteins of the Bcl-2 family are key regulators of the intrinsic pathway of apoptosis, and alterations in some of these proteins are frequently found in cancer cells. Permeabilization of t
Externí odkaz:
https://doaj.org/article/36bf7260db7a4524bbe708666314f03a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Alena Y. Streletskaia, Viacheslav V. Senichkin, Tatiana A. Prikazchikova, Timofei S. Zatsepin, Boris Zhivotovsky, Gelina S. Kopeina
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As an important regulator of apoptosis, Mcl-1 protein, a member of the Bcl-2 family, represents an attractive target for cancer treatment. The recent development of novel small molecule compounds has allowed Mcl-1-inhibitory therapy to proceed to cli
Externí odkaz:
https://doaj.org/article/fe281dc5d1934d109ba17179daeb6267
Autor:
Guilherme Fleury Perini, Glaciano Nogueira Ribeiro, Jorge Vaz Pinto Neto, Laura Tojeiro Campos, Nelson Hamerschlak
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-15 (2018)
Abstract Disruption of the physiologic balance between cell proliferation and cell death is an important step of cancer development. Increased resistance to apoptosis is a key oncogenic mechanism in several hematological malignancies and, in many cas
Externí odkaz:
https://doaj.org/article/858819c87ae64adaa18215998695dc6e
Autor:
Gülow, Marlen Michalski, Magdalena Bauer, Franziska Walz, Deniz Tümen, Philipp Heumann, Petra Stöckert, Manuela Gunckel, Claudia Kunst, Arne Kandulski, Stephan Schmid, Martina Müller, Karsten
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1666
Despite the recent approval of new therapies, the prognosis for patients with hepatocellular carcinoma (HCC) remains poor. There is a clinical need for new highly effective therapeutic options. Here, we present a combined application of BH3-mimetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::5e8335ec1a219335e2b525510befe6a9
Publikováno v:
Cells, Vol 10, Iss 7, p 1643 (2021)
Glioblastoma is a high-grade glial neoplasm with a patient survival of 12–18 months. Therefore, the identification of novel therapeutic targets is an urgent need. RAB38 is a GTPase protein implicated in regulating cell proliferation and survival in
Externí odkaz:
https://doaj.org/article/2730a9a391c54671bce32e676dda16ae