Zobrazeno 1 - 10
of 637
pro vyhledávání: '"BH3 mimetics"'
Autor:
Katja Korelin, Mayke Oostveen, Wafa Wahbi, Filipp Ianevski, Bruno Cavalcante, Laura Turunen, Ilya Belevich, Ahmed Al-Samadi, Tuula Salo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116719- (2024)
Introduction: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a five-year survival rate around 60%, indicating a need for new treatments. BH3 mimetics are small molecules that inhibit anti-apoptotic Bcl-2 family proteins, result
Externí odkaz:
https://doaj.org/article/35a14f8a81ff403c8b1964a67d2dda0c
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-3 (2024)
Abstract The anti-apoptotic BCL-2 protein family regulates cancer cell survival, thus it represents an important therapeutic target. Indeed, a drug class, called BH3-mimetics, have been developed to directly target BCL2 proteins and promote cancer ce
Externí odkaz:
https://doaj.org/article/211d4b43ab4343f7a6f91614667cf3ad
Autor:
Manuel Beltrán‐Visiedo, Nelia Jiménez‐Alduán, Rosana Díez, Marta Cuenca, Andrea Benedi, Alfonso Serrano‐Del Valle, Gemma Azaceta, Luis Palomera, Victor Peperzak, Alberto Anel, Javier Naval, Isabel Marzo
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2507-2525 (2023)
A better understanding of multiple myeloma (MM) biology has led to the development of novel therapies. However, MM is still an incurable disease and new pharmacological strategies are needed. Dinaciclib, a multiple cyclin‐dependent kinase (CDK) inh
Externí odkaz:
https://doaj.org/article/597889ddd17c42ce92b6008ca8428ba5
Autor:
Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 2, Pp 109-119 (2022)
BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis. As Bromodomain and Extra T
Externí odkaz:
https://doaj.org/article/0403c2302550453288f621f27f8c9d7f
Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract One of the many strategies that cancer cells evade death is through up-regulation of the BCL-2 anti-apoptotic proteins. Hence, these proteins have become attractive therapeutic targets. Given that different cell populations rely on different
Externí odkaz:
https://doaj.org/article/b2f20220e8744868b1bf3cfcff961dce
Publikováno v:
Acta Materia Medica, Vol 1, Iss 1, Pp 42-55 (2022)
Maintaining neuronal integrity and function requires precise mechanisms controlling organelle and protein quality. Alzheimer’s disease (AD) is also characterized by functional defects in the clearance and recycling of intracellular components. In f
Externí odkaz:
https://doaj.org/article/fbb0563d747c4fb6a58d248bc090a8f7
Autor:
Denise Müller, Paolo Mazzeo, Raphael Koch, Mark-Sebastian Bösherz, Stefan Welter, Alexander von Hammerstein-Equord, Marc Hinterthaner, Lucia Cordes, Djeda Belharazem, Alexander Marx, Philipp Ströbel, Stefan Küffer
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Multi-omics studies have shown a high and lack of common driver mutations in most thymomas (TH) and thymic carcinomas (TC) that hamper the development of novel treatment approaches. However, deregulation of apoptosis has been prop
Externí odkaz:
https://doaj.org/article/2194d474c86a458e93ca84edcaf6e9e8
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Many types of cancer such as prostate cancer, myeloid leukemia, breast cancer, glioblastoma display strong chemo resistance, which is supported by enhanced expression of multiple anti-apoptotic Bcl-2, Bcl-XL and Mcl-1 proteins. The viable anti-cancer
Externí odkaz:
https://doaj.org/article/ec09f66eca754d4292970a77ae0fbe7e
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Akademický článek
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