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Akademický článek

AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction

Autor: Lea Landolt, Jessica Furriol, Janka Babickova, Lavina Ahmed, Øystein Eikrem, Trude Skogstrand, Andreas Scherer, Salwa Suliman, Sabine Leh, James B. Lorens, Gro Gausdal, Hans‐Peter Marti, Tarig Osman

Publikováno v: Physiological Reports, Vol 7, Iss 10, Pp n/a-n/a (2019)

Abstract The AXL receptor tyrosine kinase (RTK) is involved in partial epithelial‐to‐mesenchymal transition (EMT) and inflammation – both main promoters of renal fibrosis development. The study aim was to investigate the role of AXL inhibition

Externí odkaz: https://doaj.org/article/ba28f9a6ff404566a3999026d8de02a5

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Akademický článek

Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy

Autor: Derek B. Oien, Tamás Garay, Sarah Eckstein, Jeremy Chien

Publikováno v: Frontiers in Pharmacology, Vol 8 (2018)

Reactive oxygen species (ROS) can promote or inhibit tumorigenesis. In mesothelioma, asbestos exposure to serous membranes induces ROS through iron content and chronic inflammation, and ROS promote cell survival signaling in mesothelioma. Moreover, a

Externí odkaz: https://doaj.org/article/40c98e9f73fc4c43b9531506dd9d8e52

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Akademický článek

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Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma

Publikováno v: CLINICAL CANCER RESEARCH
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Clinical cancer research, 26(13), 3319-3332. American Association for Cancer Research Inc.
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
Meel, M H, de Gooijer, M C, Metselaar, D S, Sewing, A C P, Zwaan, K, Waranecki, P, Breur, M, Buil, L C M, Lagerweij, T, Wedekind, L E, Twisk, J W R, Koster, J, Hashizume, R, Raabe, E H, Montero Carcaboso, Á, Bugiani, M, Phoenix, T N, van Tellingen, O, van Vuurden, D G, Kaspers, G J L & Hulleman, E 2020, ' Combined Therapy of AXL and HDAC Inhibition Reverses Mesenchymal Transition in Diffuse Intrinsic Pontine Glioma ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 26, no. 13, pp. 3319-3332 . https://doi.org/10.1158/1078-0432.CCR-19-3538
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(13), 3319-3332. American Association for Cancer Research Inc.

Purpose: Diffuse intrinsic pontine glioma (DIPG) is an incurable type of pediatric brain cancer, which in the majority of cases is driven by mutations in genes encoding histone 3 (H3K27M). We here determined the preclinical therapeutic potential of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbb14803b278a300a27ba729f2fb2d2
http://www.scopus.com/inward/record.url?scp=85085984319&partnerID=8YFLogxK

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A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target

Autor: Montserrat Marí, Anna Tutusaus, Cristina Aresté, Estefanía de Gregorio, Mar Coll, Albert Morales, James B. Lorens, Pablo García de Frutos, Gro Gausdal, Anna Colell, Blanca Cucarull, Isabel Graupera, Helena Cristóbal

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology (CMGH)
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 349-368 (2020)

Background and Aims: GAS6 signaling, through the TAM receptor tyrosine kinases AXL and MERTK, participates in chronic liver pathologies. Here, we addressed GAS6/TAM involvement in Non-Alcoholic SteatoHepatitis (NASH) development. Methods: GAS6/TAM si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd0af491353a59385b69d42035b9ec9
http://hdl.handle.net/10261/223520

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RETRACTED ARTICLE: Long noncoding RNA H19 regulates HIF-1α/AXL signaling through inhibiting miR-20b-5p in endometrial cancer

Autor: He Zhu, Xue-Man Lyu, Fei Wu, Limei Fan, Yue-Mei Jin

Publikováno v: Cell Cycle. 18:2454-2464

In a variety of cancers, long non-coding RNAs (lncRNAs) were believed to play important roles. Nevertheless, H19's possible molecular mechanism related to miR-20b-5p has not yet been explored in endometrial cancer. Differential lncRNAs in endometrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7402fba786a5bfe55e84e87ca0ffbf57
https://doi.org/10.1080/15384101.2019.1648958

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Axl signaling is an important mediator of tumor angiogenesis

Autor: Dietmar W. Siemann, Mai Tanaka

Publikováno v: Oncotarget

The growth of primary tumors as well as metastatic neoplastic lesions is strongly dependent on the cancer cells’ ability to initiate their own vascular network. This process, angiogenesis, which involves the proliferation, migration, and invasion o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f173756b0afd7f01f9e4cc7aab3ee80f
http://europepmc.org/articles/PMC6499597

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Akademický článek

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Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling

Autor: Mai Tanaka, Dietmar W. Siemann, Samantha S. Dykes

Publikováno v: Clinical & Experimental Metastasis

Approximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell dissemination. Key steps in the metastatic cascade are promoted through upregulation of critical cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316707d05f39001c69bbb99acdddbaa1
https://pubmed.ncbi.nlm.nih.gov/33791875

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