Binding of C4b-binding protein to porin: A molecular mechanism of serum resistance of Neisseria gonorrhoeae

Autor: S Ram, Meabh Cullinane, AM Blom, S Gulati, DP McQuillen, BG Monks, C O'Connell, R Boden, C Elkins, MK Pangburn, B Dahlbäck, PA Rice

We screened 29 strains of Neisseria gonorrhoeae and found 16/21 strains that resisted killing by normal human serum and 0/8 serum sensitive strains that bound the complement regulator, C4b-binding protein (C4bp). Microbial surface-bound C4bp demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bdc8f77b6486be5b959363a15489ed7

Stable serum resistance of Neisseria gonorrhoeae is mediated by binding of C4B-binding protein to gonococcal porin

Autor: S Ram, Christopher Elkins, PA Rice, Anna M. Blom, Michael K. Pangburn, M Cullinane, Daniel P. McQuillen, S Gulati, Björn Dahlbäck, BG Monks

Publikováno v: Immunopharmacology. 49:58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::417bd7d7c5ce73f17b6999c3547f4fcc
https://doi.org/10.1016/s0162-3109(00)80164-2

A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.

Autor: Shaughnessy J; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Gulati S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Agarwal S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Unemo M; World Health Organization Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine and Microbiology, Orebro University Hospital, SE-701 85 Orebro, Sweden;, Ohnishi M; National Institute of Infectious Diseases, Tokyo 162-8640, Japan;, Su XH; Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042, China;, Monks BG; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605; Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany;, Visintin A; Centers for Therapeutic Innovation, Pfizer, Inc., Cambridge, MA 02139;, Madico G; Section of Infectious Diseases, Boston Medical Center, Boston, MA 02118; and., Lewis LA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Golenbock DT; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Reed GW; Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester MA 01605., Rice PA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605;, Ram S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester MA 01605; sanjay.ram@umassmed.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Feb 15; Vol. 196 (4), pp. 1732-40. Date of Electronic Publication: 2016 Jan 15.

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Autor: Franklin BS; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany., Bossaller L; 1] Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., De Nardo D; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany., Ratter JM; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany., Stutz A; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany., Engels G; Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany., Brenker C; German Center for Neurodegenerative Diseases, Bonn, Germany., Nordhoff M; German Center for Neurodegenerative Diseases, Bonn, Germany., Mirandola SR; German Center for Neurodegenerative Diseases, Bonn, Germany., Al-Amoudi A; German Center for Neurodegenerative Diseases, Bonn, Germany., Mangan MS; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] German Center for Neurodegenerative Diseases, Bonn, Germany., Zimmer S; Department of Medicine/Cardiology, University Hospitals, University of Bonn, Bonn, Germany., Monks BG; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Fricke M; Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany., Schmidt RE; Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany., Espevik T; Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Jones B; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia., Jarnicki AG; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia., Hansbro PM; Centre for Asthma and Respiratory Disease, The University of Newcastle, Newcastle, Australia., Busto P; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Marshak-Rothstein A; Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Hornemann S; University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland., Aguzzi A; University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland., Kastenmüller W; Institute of Molecular Medicine and Experimental Immunology, University Hospitals, University of Bonn, Bonn, Germany., Latz E; 1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany. [4] Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Publikováno v: Nature immunology [Nat Immunol] 2014 Aug; Vol. 15 (8), pp. 727-37. Date of Electronic Publication: 2014 Jun 22.

ASC speck formation as a readout for inflammasome activation.

Autor: Stutz A; Institute of Innate Immunity, University Hospital, University of Bonn, Bonn, Germany., Horvath GL, Monks BG, Latz E

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2013; Vol. 1040, pp. 91-101.