Zobrazeno 1 - 10
of 1 025
pro vyhledávání: '"BET inhibitor"'
Autor:
Zhenzhen Jiang, Guangqing Cai, Haiting Liu, Leping Liu, Rong Huang, Xinmin Nie, Rong Gui, Jian Li, Jinqi Ma, Ke Cao, Yanwei Luo
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Combination therapy involving immune checkpoint blockade (ICB) and other drugs is a potential strategy for converting immune-cold tumors into immune-hot tumors to benefit from immunotherapy. To achieve drug synergy, we developed a
Externí odkaz:
https://doaj.org/article/a85048a859814ff5baf461bad2ecc150
Autor:
Manuela Iten, Camille Gschwend, Alessandro Ostini, David Robert Cameron, Christine Goepfert, David Berger, Matthias Haenggi
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-8 (2024)
Abstract Background Acute respiratory distress syndrome (ARDS) is a form of respiratory failure stemming from various underlying conditions that ultimately lead to inflammation and lung fibrosis. Bromodomain and Extra-Terminal motif (BET) inhibitors
Externí odkaz:
https://doaj.org/article/d6858289bc504be9a53abfc996c41019
Publikováno v:
Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 1, Pp 67-72 (2024)
NUT carcinomas (NCs) are a group of rare tumors that can occur anywhere in the body and are defined by the fusion of the nuclear protein in testis (NUTM1) resulting in increased transcription of proto-oncogenes. NCs have a poor prognosis that varies
Externí odkaz:
https://doaj.org/article/3cb038dcb4134b309adfab6871b4ee9e
Autor:
Yu Meng, Hui-Yan Sun, Yi He, Qian Zhou, Yi-Huang Liu, Hui Su, Ming-Zhu Yin, Fu-Rong Zeng, Xiang Chen, Guang-Tong Deng
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/397467047a774b85b98b57d86241bd49
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 943 (2024)
Bromodomain and extra-terminal domain (BET) family proteins regulate transcription and recognize lysine residues in histones. Selective BET inhibitors targeting one domain have attracted attention because they maintain normal physiological activities
Externí odkaz:
https://doaj.org/article/939e8fd8be6a49e29432db1f9f2e4305
Autor:
Li Ma, Jianwei Wang, Yang Yang, Jun Lu, Jing Ling, Xinran Chu, Zimu Zhang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Yongping Zhang, Xu Sang, Lihui Lu, Xiaomei Wan, Kunlong Zhang, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jian Pan, Xiuxia Zhou, Yixin Hu, Shaoyan Hu
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTIntroduction B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit hig
Externí odkaz:
https://doaj.org/article/8830c93d24874c8c9bbbe71260e44762
Publikováno v:
Molecules, Vol 29, Iss 8, p 1784 (2024)
Detecting the unintended adverse reactions of drugs (ADRs) is a crucial concern in pharmacological research. The experimental validation of drug–ADR associations often entails expensive and time-consuming investigations. Thus, a computational model
Externí odkaz:
https://doaj.org/article/6268fac762604c38899ad8b5c1257b4e
Autor:
Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 45, Iss , Pp 100936- (2023)
The mortality rates of gastric cancer remain high due to limited therapeutic strategies. As a highly selective inhibitor of the BD2 domain of BET family proteins, ABBV-744 has potent chemotherapeutic activity against various human solid tumors. Howev
Externí odkaz:
https://doaj.org/article/df8892d4b9c8404da363ac8466db28f4
Analysis of differentially expressed long non-coding RNAs in LPS-induced human HMC3 microglial cells
Autor:
Mina Baek, Jin Choul Chai, Hae In Choi, Eunyoung Yoo, Bert Binas, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background Long non-coding RNAs (lncRNAs) are emerging as key modulators of inflammatory gene expression, but their roles in neuroinflammation are poorly understood. Here, we identified the inflammation-related lncRNAs and correlated mRNAs o
Externí odkaz:
https://doaj.org/article/4b447e2a22fc4c1f8c16d2053af8ccaf
Autor:
Pradeep Reddy Cingaram
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 142-143 (2023)
Externí odkaz:
https://doaj.org/article/90e795e8dceb459d9c7fa4bb9a4a8df6