Zobrazeno 1 - 10
of 697
pro vyhledávání: '"BET bromodomain"'
Autor:
Victoria L. Alonso, Andrea M. Escalante, Elvio Rodríguez Araya, Gianfranco Frattini, Luis E. Tavernelli, Diego M. Moreno, Ricardo L. E. Furlan, Esteban Serra
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose
Externí odkaz:
https://doaj.org/article/625fa16de8e24adda2e8694cf21c87f1
Autor:
Joshua A. Nord, Sarah L. Wynia-Smith, Alyssa L. Gehant, Rachel A. Jones Lipinski, Aaron Naatz, Inmaculada Rioja, Rab K. Prinjha, John A. Corbett, Brian C. Smith
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Chronic inflammation of pancreatic islets is a key driver of β-cell damage that can lead to autoreactivity and the eventual onset of autoimmune diabetes (T1D). In the islet, elevated levels of proinflammatory cytokines induce the transcription of th
Externí odkaz:
https://doaj.org/article/cb05e51596ea4c4db54e368ed7161c17
Akademický článek
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Autor:
Monika Krošel, Larissa Moser, Miranda Houtman, Jasna Friščić, Matija Tomšič, Oliver Distler, Markus H. Hoffmann, Caroline Ospelt, Kerstin Klein
Publikováno v:
Cells, Vol 12, Iss 8, p 1149 (2023)
Bromodomain- and extra-terminal domain (BET) proteins are epigenetic reader proteins that regulate transcription of their target genes by binding to acetylated histone side chains. Small molecule inhibitors, such as I-BET151, have anti-inflammatory p
Externí odkaz:
https://doaj.org/article/d413c1c57737474a8132697eded9b1e9
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 54-63 (2021)
(1) Background: BET bromodomain proteins regulate transcription by binding acetylated histones and attracting key factors for, e.g., transcriptional elongation. BET inhibitors have been developed to block pathogenic processes such as cancer and infla
Externí odkaz:
https://doaj.org/article/d8a1fde87cbd4cd0a51263ea7e447d9a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Katiri J. Snyder, Hannah K. Choe, Yandi Gao, Natalie E. Sell, Kara M. Braunreiter, Nina C. Zitzer, Lotus Neidemire-Colley, Sonu Kalyan, Adrienne M. Dorrance, Andrea Keller, Maria M. Mihaylova, Satishkumar Singh, Lalit Sehgal, Gideon Bollag, Yan Ma, Ben Powell, Steven M. Devine, Parvathi Ranganathan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Acute graft-versus-host disease (GVHD) is the leading cause of non-relapse mortality following allogeneic hematopoietic cell transplantation. The majority of patients non-responsive to front line treatment with steroids have an estimated overall 2-ye
Externí odkaz:
https://doaj.org/article/56efe39a20fb494faaa4960077ed69ab
Autor:
Dayu Wu, Qiong Duan
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1032 (2022)
BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins. BETs play crucial roles in cancer, infla
Externí odkaz:
https://doaj.org/article/dd89942afbeb42f1b9ce55de10dec5c1
Autor:
Weiping Li, Shiv K. Gupta, Weiguo Han, Ryan A. Kundson, Sara Nelson, Darlene Knutson, Patricia T. Greipp, Sherine F. Elsawa, Eduardo M. Sotomayor, Mamta Gupta
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract Double/triple-hit lymphomas (DHL/THL) account for 5–10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression. Despite the poor prognosis of DHL, R-CHOP chemotherapy remains
Externí odkaz:
https://doaj.org/article/00911363edb0454eabfd03124bddd6dc
Autor:
Brown, Jonathan D., Feldman, Zachary B., Doherty, Sean P., Reyes, Jaime M., Rahl, Peter B., Lin, Charles Y., Sheng, Quanhu, Duan, Qiong, Federation, Alexander J., Kung, Andrew L., Haldar, Saptarsi M., Young, Richard A., Plutzky, Jorge, Bradner, James E.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb . 115(9), 2144-2149.
Externí odkaz:
https://www.jstor.org/stable/26507955