Zobrazeno 1 - 10
of 251
pro vyhledávání: '"BERNARD REES-SMITH"'
Autor:
Navoda Atapattu, Marie Amoroso, Michael Powell, D. G. Harendra de Silva, K. Shamya H. de Silva, Jadwiga Furmaniak, Bernard Rees Smith, Lakdasa D. Premawardhana
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThere is limited information about diabetes and thyroid related autoantibodies in children with type 1 diabetes (T1D) or their siblings in Sri Lanka.ObjectivesTo assess in T1D children and their unaffected siblings the prevalence of autoant
Externí odkaz:
https://doaj.org/article/cf807485322e46b682f0386a67dc960c
Autor:
Carina Törn, Fariba Vaziri-Sani, Anita Ramelius, Helena Elding Larsson, Sten Anders Ivarsson, Marie Amoroso, Jadwiga Furmaniak, Michael Powell, Bernard Rees Smith
Publikováno v:
Acta Diabetologica. 59:773-781
AimThe study aim was to evaluate the RSR 3 Screen ICA™ and 2 Screen ICA™ for detection of islet cell autoimmunity in healthy Swedish subjects and patients with newly diagnosed type 1 diabetes (T1D).Methods3 Screen is designed for combined detecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a744b8020421eedb2984c672634791c
https://doi.org/10.1007/s00592-022-01856-5
https://doi.org/10.1007/s00592-022-01856-5
Publikováno v:
Clinical Endocrinology. 96:878-887
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96f1363aafe4532cc5bc7f3aa5dc3329
https://doi.org/10.1111/cen.14681
https://doi.org/10.1111/cen.14681
Autor:
Ricardo Núñez Miguel, Paul Sanders, Lloyd Allen, Michele Evans, Matthew Holly, William Johnson, Andrew Sullivan, Jane Sanders, Jadwiga Furmaniak, Bernard Rees Smith
Publikováno v:
Journal of Molecular Endocrinology. 70
Determination of the full-length thyroid-stimulating hormone receptor (TSHR) structure by cryo-electron microscopy (cryo-EM) is described. The TSHR complexed with human monoclonal TSHR autoantibody K1-70™ (a powerful inhibitor of TSH action) was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b459f97ebeff71aaea7b02a47ddf258a
https://doi.org/10.1530/jme-22-0120
https://doi.org/10.1530/jme-22-0120
Cryo-electron microscopy structures of human thyroid peroxidase (TPO) in complex with TPO antibodies
Autor:
Stuart Baker, Ricardo Núñez Miguel, Daniel Thomas, Michael Powell, Jadwiga Furmaniak, Bernard Rees Smith
Publikováno v:
Journal of molecular endocrinology.
Determination of the structure of the extracellular domain of human thyroid peroxidase (hTPO) by cryo-electron microscopy (cryo-EM) is described. TPO, purified to homogeneity was complexed with the hTPO monoclonal autoantibody 2G4 Fab and also with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6462e490993c6160656300aad4375d60
https://pubmed.ncbi.nlm.nih.gov/36537574
https://pubmed.ncbi.nlm.nih.gov/36537574
Autor:
Jane Sanders, Paul W. Sanders, James A. Garrity, Mark A. Wentworth, Alicia Algeciras-Schimnich, Stuart Young, Bernard Rees Smith, Jadwiga Furmaniak, John C. Morris, Mabel Ryder
Publikováno v:
Thyroid.
Background: We report the therapeutic use of K1-70™, a thyrotropin receptor (TSHR) antagonist monoclonal antibody, in a patient with follicular thyroid cancer (FTC), Graves' disease (GD), and Grave...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43160d2415c2bb1fbd5a848d49b7dad
https://doi.org/10.1089/thy.2021.0053
https://doi.org/10.1089/thy.2021.0053
Autor:
Jun Guan, Shu Chen, Bernard Rees Smith, Liang Guo, Michael Powell, Zhida Wang, Liming Chen, Jadwiga Furmaniak
Publikováno v:
Acta diabetologica. 59(2)
Aims To assess the prevalence of diabetes-associated autoantibodies in Chinese patients recently diagnosed with adult-onset diabetes and to evaluate the potential role of the autoantibody markers for characterization of disease phenotype in the patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aeb4b16c2947b8bb6c1b8854257d68b
https://pubmed.ncbi.nlm.nih.gov/34533636
https://pubmed.ncbi.nlm.nih.gov/34533636
Autor:
Jill Clark, Bernard Rees Smith, Jadwiga Furmaniak, Yang Li, Paul W. Sanders, Jane Sanders, Jane Wilmot
Publikováno v:
Autoimmunity Highlights
Background The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies. Methods The preclinical toxicology assessment following we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e8c6fc7ed8cd2d2b0ac01e443f8760
http://europepmc.org/articles/PMC7065368
http://europepmc.org/articles/PMC7065368
Autor:
Peter Achenbach, Ezio Bonifacio, Claudia Matzke, Bernard Rees Smith, Marie Amoroso, Anette-G. Ziegler, Michael Powell, Jadwiga Furmaniak, Christiane Winkler, F Haupt, Cigdem Gezginci, Stephanie Löbner, Andreas Beyerlein, Stephanie Zillmer, Rebecca Coles, Marlon Scholz, Susanne Wittich, Katharina Weininger, Stephanie Riethausen
Publikováno v:
Diabetes Technology & Therapeutics. 18:687-693
Testing for beta cell autoantibodies is used for wide-scale identification of early stages of type 1 diabetes. This requires suitable screening assays. We aimed to establish screening that utilized a first step assay (3 Screen) able to detect autoant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919676589fb4f525680f516c7132fe2f
https://doi.org/10.1089/dia.2016.0199
https://doi.org/10.1089/dia.2016.0199
Autor:
Anette-G. Ziegler, Ezio Bonifacio, Monika Chlebowska, Bernard Rees Smith, Marie Amoroso, Lorraine Carr, Jadwiga Furmaniak, Rebecca Coles, Michael Powell, Peter Achenbach, Marlon Scholz
Publikováno v:
Clinica Chimica Acta. 462:60-64
3 Screen, a new ELISA for the combined measurement of autoantibodies to GAD65, to IA-2 and to ZnT8, has been developed and evaluated. In the assay serum samples were incubated (overnight; 2-8°C) in ELISA plate wells coated with GAD65, IA-2 and ZnT8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd120822985e37f5301da788e219e4d
https://doi.org/10.1016/j.cca.2016.08.013
https://doi.org/10.1016/j.cca.2016.08.013