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51346 Use of mRNA and miRNA sequencing to demonstrate the clinical senomorphic and anti-aging activity of a combination of niacinamide and hyaluronic acid on human skin biopsies

Autor: BOGDANOWICZ, Patrick, JACQUES-JAMIN, Carine, BIANCHI, Pascale, BEGANTON, Benoît, Mias, Céline, BENSADOUN, Paul, Bessou-Touya, Sandrine, Lemaitre, Jean-Marc, DUPLAN, Hélène

Publikováno v: In Journal of the American Academy of Dermatology September 2024 91(3) Supplement:AB353-AB353

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Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells

Autor: Beauvarlet, Jennifer, Bensadoun, Paul, Darbo, Elodie, Labrunie, Gaelle, Rousseau, Benoît, Richard, Elodie, Draskovic, Irena, Londono-Vallejo, Arturo, Dupuy, Jean-William, Nath Das, Rabindra, Guédin, Aurore, Robert, Guillaume, Orange, Francois, Croce, Sabrina, Valesco, Valerie, Soubeyran, Pierre, Ryan, Kevin M, Mergny, Jean-Louis, Djavaheri-Mergny, Mojgan

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2019, 47 (6), pp.2739-2756. ⟨10.1093/nar/gkz095⟩
Nucleic Acids Research, 2019, 47 (6), pp.2739-2756. ⟨10.1093/nar/gkz095⟩

International audience; G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest and cell death induced by these ligands

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0b3f592e4ac28c92c821f6791f87b15a
https://hal.sorbonne-universite.fr/hal-02038474/document

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Autor: Gentili, Matteo, Lahaye, Xavier, Nadalin, Francesca, Nader, Guilherme P.F., Puig Lombardi, Emilia, Herve, Solène, De Silva, Nilushi, Rookhuizen, Derek, Zueva, Elina, Goudot, Christel, Maurin, Mathieu, Bochnakian, Aurore, Amigorena, Sebastian, Piel, Matthieu, Fachinetti, Daniele, Manel, Nicolas, Beauvarlet, Jennifer, Bensadoun, Paul, Darbo, Elodie, Labrunie, Gaelle, Rousseau, Benoit, Richard, Elodie, Draskovic, Irena, Dupuy, Jean-William, Nath Das, Rabindra, Guédin, Aurore, Robert, Guillaume, Orange, François, Croce, Sabrina, Valesco, Valerie, Soubeyran, Pierre, Ryan, Kevin, Mergny, Jean-Louis, Mergny, Mojgan, Borie, Raphael, Bouvry, Diane, Cottin, Vincent, Gauvain, Clement, Cazes, Aurélie, Debray, Marie-Pierre, Cadranel, Jacques, Dieudé, Philippe, Degot, Tristan, Dominique, Stéphane, Gamez, Anne Sophie, Jaillet, Madeleine, Juge, Pierre-Antoine, Londono-Vallejo, Arturo, Mailleux, Arnaud, Mal, Herve, Boileau, Catherine, Ménard, Christelle, Nunes, Hilario, Prevot, Grégoire, Quetant, Sébastien, Revy, Patrick, Traclet, Julie, Wemeau-Stervinou, Lidwine, Wislez, Marie, Kannengiesser, Caroline, Crestani, Bruno

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2019, 26 (9), pp.2377-2393.e13. ⟨10.1016/j.celrep.2019.01.105⟩
Cell Reports, Elsevier Inc, 2019, 26, pp.2377-2393.e13. ⟨10.1016/j.celrep.2019.01.105⟩

Summary Cytosolic DNA activates cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), an innate immune sensor pivotal in anti-microbial defense, senescence, auto-immunity, and cancer. cGAS is considered to be a sequence-inde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c6233ce42f61960277c231daa1c8789
http://europepmc.org/articles/PMC6391843