Conditioned pain modulation is more efficient in painful than in non-painful diabetic polyneuropathy patients

Autor: Granovsky, Y, Topaz, LS, Laycock, H, Zubidat, R, Crystal, S, Buxbaum, C, Bosak, N, Hadad, R, Domany, E, Khamaisi, M, Sprecher, E, Bennett, DL, Rice, A, Yarnitsky, D

Endogenous pain modulation, as tested by the conditioned pain modulation (CPM) protocol, is typically less efficient in chronic pain patients compared to healthy controls. We aimed to assess whether CPM is less efficient in painful compared to non-pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::a3a036fafc2aa1343397ebcb6a82843e
http://hdl.handle.net/10044/1/91099

Germline selection shapes human mitochondrial DNA diversity

Autor: Wei, W, Tuna, S, Keogh, MJ, Smith, KR, Aitman, TJ, Beales, PL, Bennett, DL, Gale, DP, Bitner-Glindzicz, MAK, Black, GC, Brennan, P, Elliott, P, Flinter, FA, Floto, RA, Houlden, H, Irving, M, Koziell, A, Maher, ER, Markus, HS, Morrell, NW, Newman, WG, Roberts, I, Sayer, JA, Smith, KGC, Taylor, JC, Watkins, H, Webster, AR, Wilkie, AOM, Williamson, C, Attwood, A, Brown, M, Brod, NC, Crisp-Hihn, A, Davis, J, Deevi, SVV, Dewhurst, EF, Edwards, K, Erwood, M, Fox, J, Frary, AJ, Hu, F, Jolley, J, Kingston, N, Linger, R, Mapeta, R, Martin, J, Meacham, S, Papadia, S, Rayner-Matthews, PJ, Samarghitean, C, Shamardina, O, Simeoni, I, Staines, S, Staples, E, Stark, H, Stephens, J, Titterton, C, Von Ziegenweidt, J, Watt, C, Whitehorn, D, Wood, Y, Yates, K, Yu, P, James, R, Ashford, S, Penkett, CJ, Stirrups, KE, Bariana, T, Lentaigne, C, Sivapalaratnam, S, Westbury, SK, Allsup, DJ, Bakchoul, T, Biss, T, Boyce, S, Collins, J, Collins, PW, Curry, NS, Downes, K, Dutt, T, Erber, WN, Evans, G, Everington, T, Favier, R, Gomez, K, Greene, D, Gresele, P, Hart, D, Kazmi, R, Kelly, AM, Lambert, M, Madan, B, Mangles, S, Mathias, M, Millar, C, Obaji, S, Peerlinck, K, Roughley, C, Schulman, S, Scully, M, Shapiro, SE, Sibson, K, Sims, MC, Tait, RC, Talks, K, Thys, C, Toh, C-H, Van Geet, C, Westwood, J-P, Mumford, AD, Ouwehand, WH, Freson, K, Laffan, MA, Tan, RYY, Harkness, K, Mehta, S, Muir, KW, Hassan, A, Traylor, M, Drazyk, AM, Parry, D, Ahmed, M, Kazkaz, H, Vandersteen, AM, Ormondroyd, E, Thomson, K, Dent, T, Buchan, RJ, Bueser, T, Carr-White, G, Cook, S, Daniels, MJ, Harper, AR, Ware, JS, Dixon, PH, Chambers, J, Cheng, F, Estiu, MC, Hague, WM, Marschall, H-U, Vazquez-Lopez, M, Arno, G, French, CE, Michaelides, M, Moore, AT, Sanchis-Juan, A, Carss, K, Raymond, FL, Chinnery, PF, Griffiths, P, Horvath, R, Hudson, G, Jurkute, N, Pyle, A, Yu-Wai-Man, P, Whitworth, J, Adlard, J, Armstrong, R, Brewer, C, Casey, R, Cole, TRP, Evans, DG, Greenhalgh, L, Hanson, HL, Hoffman, J, Izatt, L, Kumar, A, Lalloo, F, Ong, KR, Park, S-M, Searle, C, Side, L, Snape, K, Woodward, E, Tischkowitz, M, Grozeva, D, Kurian, MA, Themistocleous, AC, Gosal, D, Marshall, A, Matthews, E, McCarthy, MI, Renton, T, Rice, ASC, Vale, T, Walker, SM, Woods, CG, Thaventhiran, JE, Allen, HL, Savic, S, Alachkar, H, Antrobus, R, Baxendale, HE, Browning, MJ, Buckland, MS, Cooper, N, Edgar, JDM, Egner, W, Gilmour, KC, Goddard, S, Gordins, P, Grigoriadou, S, Hackett, S, Hague, R, Hayman, G, Herwadkar, A, Huissoon, AP, Jolles, S, Kelleher, P, Kumararatne, D, Longhurst, H, Lorenzo, LE, Lyons, PA, Maimaris, J, Noorani, S, Richter, A, Sargur, RB, Sewell, WAC, Thomas, D, Thomas, MJ, Worth, A, Yong, PFK, Kuijpers, TW, Thrasher, AJ, Levine, AP, Sadeghi-Alavijeh, O, Wong, EKS, Cook, HT, Chan, MMY, Hall, M, Harris, C, McAlinden, P, Marchbank, KJ, Marks, S, Maxwell, H, Mozere, M, Wessels, J, Johnson, SA, Bleda, M, Hadinnapola, C, Haimel, M, Swietlik, E, Bogaard, H, Church, C, Coghlan, G, Condliffe, R, Corris, P, Danesino, C, Eyries, M, Gall, H, Ghofrani, H-A, Gibbs, JSR, Girerd, B, Holden, S, Houweling, A, Howard, LS, Humbert, M, Kiely, DG, Kovacs, G, Lawrie, A, Ross, RVM, Moledina, S, Montani, D, Newnham, M, Olschewski, A, Olschewski, H, Peacock, A, Pepke-Zaba, J, Scelsi, L, Seeger, W, Soubrier, F, Suntharalingam, J, Toshner, M, Treacy, C, Trembath, R, Noordegraaf, AV, Waisfisz, Q, Wharton, J, Wilkins, MR, Wort, SJ, Graf, S, Louka, E, Roy, NB, Rao, A, Ancliff, P, Babbs, C, Layton, DM, Mead, AJ, O'Sullivan, J, Okoli, S, Saleem, M, Bierzynska, A, Diz, CB, Colby, E, Ekani, MN, Satchell, S, Fowler, T, Rendon, A, Scott, R, Smedley, D, Thomas, E, Caulfield, M, Abbs, S, Burrows, N, Chitre, M, Gattens, M, Gurnell, M, Kelsall, W, Poole, KES, Ross-Russell, R, Spasic-Boskovic, O, Twiss, P, Wagner, A, Banka, S, Clayton-Smith, J, Douzgou, S, Abulhoul, L, Aurora, P, Bockenhauer, D, Cleary, M, Dattani, M, Ganesan, V, Pilkington, C, Rahman, S, Shah, N, Wedderburn, L, Compton, CJ, Deshpande, C, Fassihi, H, Haque, E, Josifova, D, Mohammed, SN, Robert, L, Rose, SJ, Ruddy, DM, Sarkany, RN, Sayer, G, Shaw, AC, Campbell, C, Gibson, K, Koelling, N, Lester, T, Nemeth, AH, Palles, C, Patel, S, Sen, A, Taylor, J, Tomlinson, IP, Malka, S, Browning, AC, Burn, J, De Soyza, A, Graham, J, Pearce, S, Quinton, R, Schaefer, AM, Wilson, BT, Wright, M, Simpson, M, Syrris, P, Bradley, JR, Turro, E

Publikováno v: NIHR BioResource–Rare Diseases, 100,000 Genomes Project–Rare Diseases Pilot & Daniels, M J 2019, ' Germline selection shapes human mitochondrial DNA diversity ', Science (New York, N.Y.), vol. 364, no. 6442 . https://doi.org/10.1126/science.aau6520
Science, 364(6442). American Association for the Advancement of Science
Science
Tomlinson, I 2019, ' Germline selection shapes human mitochondrial DNA diversity ', Science, vol. 364, no. 6442, pp. 749-+ . https://doi.org/10.1126/science.aau6520

INTRODUCTION Only 2.4% of the 16.5-kb mitochondrial DNA (mtDNA) genome shows homoplasmic variation at >1% frequency in humans. Migration patterns have contributed to geographic differences in the frequency of common genetic variants, but population g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0acfee6b4573c8d6320d0057b56790

The clinical approach to small fibre neuropathy and painful channelopathy

Autor: Themistocleous, AC, Ramirez, JD, Serra, J, Bennett, DL

Small fibre neuropathy (SFN) is characterised by structural injury selectively affecting small diameter sensory and/or autonomic axons. The clinical presentation is dominated by pain. SFN complicates a number of common diseases such as diabetes melli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2ad8a2578b058ac2417125a2bbd686a9
https://doi.org/10.1136/practneurol-2013-000758

Brain microglia in psychiatric disorders

Autor: Mondelli, Valeria, Vernon, Anthony C, Turkheimer, Federico, Dazzan, Paola, Pariante, Carmine M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., et, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, Peferoen, LA, Vogel, DY, Ummenthum, K, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Steiner, J, Bielau, H, Brisch, R, Schnieder, TP, Trencevska, I, Rosoklija, G, Fillman, SG, Cloonan, N, Catts, VS, Rupprecht, R, Papadopoulos, V, Rammes, G, Qiu, ZK, Li, MS, He, JL, Hannestad, J, Gallezot, JD, Schafbauer, T, Israel, I, Ohsiek, A, Al-Momani, E, Mirzaei, N, Tang, SP, Ashworth, S, Gulyás, B, Makkai, B, Kása, P, Turkheimer, FE, Rizzo, G, Bloomfield, PS, Owen, DR, Yeo, AJ, DellaGioia, N, Setiawan, E, Wilson, AA, Su, L, Faluyi, YO, Hong, YT, Haarman, BC, Lek, RF Riemersma-Van der, Groot, JC de, Berckel, BN van, Bossong, MG, Boellaard, R, Doorduin, J, Vries, EF de, Willemsen, AT, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, Kenk, M, Selvanathan, T, Rao, N, Selvaraj, S, Veronese, M, Coughlin, JM, Wang, Y, Ambinder, EB, Doef, TF van der, Witte, LD de, Sutterland, AL, Hafizi, S, Tseng, HH, Holmes, SE, Hinz, R, Drake, RJ, Yaqub, M, Schuitemaker, A, Edison, P, Pavese, N, Lockhart, A, Davis, B, Matthews, JC, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, Cahn, W, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Brocklehurst, S, Miller, DH, Kubicki, M, Park, H, Westin, CF, Bouix, S, Dahlben, B, Oestreich, LK, Shenton, ME, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Ambler, A, Poulton, R, Caspi, A, Akhtar, R, Ciufolini, S, Meyer, U, So, PW, Lythgoe, DJ, Cotel, MC, Lenartowicz, EM, Anacker, C, Calcia, MA, Bonsall, DR, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F La, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Gschwind, T, Varga, B, Markó, K, Hádinger, N, Cattaneo, A, Ferrari, C, Uher, R, Belvederi, Murri M, Sandiego, CM, Pittman, B, Weber, MD, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Bard, F, Bhattacharya, A, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N

Publikováno v: Lancet psychiatry, 0(0), 587-597. Elsevier Limited
Mondelli, V, Vernon, A C, Turkheimer, F E, Dazzan, P & Pariante, C M 2017, ' Brain microglia in psychiatric disorders ', The Lancet Psychiatry, vol. 4, no. 7, pp. 563-572 . https://doi.org/10.1016/S2215-0366(17)30101-3
Mondelli, V, Vernon, A C, Turkheimer, F, Dazzan, P, Pariante, C M, Frost, JL, Schafer, DP, Banati, RB, Newcombe, J, Gunn, RN, al., E, Tang, Y, Le, W, Estes, ML, McAllister, AK, Ransohoff, RM, Davalos, D, Grutzendler, J, Yang, G, al., E, Peferoen, LA, Vogel, DY, Ummenthum, K, al., E, Norden, DM, Trojanowski, PJ, Villanueva, E, Navarro, E, Godbout, JP, Kreisel, T, Frank, MG, Licht, T, al., E, Wachholz, S, Eßlinger, M, Plümper, J, Manitz, MP, Juckel, G, Friebe, A, Trépanier, MO, Hopperton, KE, Mizrahi, R, Mechawar, N, Bazinet, RP, Torres-Platas, SG, Cruceanu, C, Chen, GG, Turecki, G, Mechawar, N, Steiner, J, Bielau, H, Brisch, R, al., E, Schnieder, TP, Trencevska, I, Rosoklija, G, al., E, Fillman, SG, Cloonan, N, Catts, VS, al., E, Rupprecht, R, Papadopoulos, V, Rammes, G, al., E, Qiu, ZK, Li, MS, He, JL, al., E, Hannestad, J, Gallezot, JD, Schafbauer, T, al., E, Israel, I, Ohsiek, A, Al-Momani, E, al., E, Mirzaei, N, Tang, SP, Ashworth, S, al., E, Gulyás, B, Makkai, B, Kása, P, al., E, Turkheimer, FE, Rizzo, G, Bloomfield, PS, al., E, Owen, DR, Yeo, AJ, Gunn, RN, al., E, Hannestad, J, DellaGioia, N, Gallezot, JD, al., E, Setiawan, E, Wilson, AA, Mizrahi, R, al., E, Su, L, Faluyi, YO, Hong, YT, al., E, Haarman, BC, Lek, RF R-V D, Groot, JC D, al., E, Berckel, BN V, Bossong, MG, Boellaard, R, al., E, Doorduin, J, Vries, EF D, Willemsen, AT, Groot, JC D, Dierckx, RA, Klein, HC, Takano, A, Arakawa, R, Ito, H, al., E, Kenk, M, Selvanathan, T, Rao, N, al., E, Bloomfield, PS, Selvaraj, S, Veronese, M, al., E, Coughlin, JM, Wang, Y, Ambinder, EB, al., E, Doef, TF V D, Witte, LD D, Sutterland, AL, al., E, Hafizi, S, Tseng, HH, Rao, N, al., E, Holmes, SE, Hinz, R, Drake, RJ, al., E, Yaqub, M, Berckel, BN V, Schuitemaker, A, al., E, Turkheimer, FE, Edison, P, Pavese, N, al., E, Lockhart, A, Davis, B, Matthews, JC, al., E, Quarantelli, M, Laule, C, Vavasour, IM, Kolind, SH, al., E, Pasternak, O, Sochen, N, Gur, Y, Intrator, N, Assaf, Y, Andreasen, NC, Ehrhardt, JC, Swayze, VW, al., E, Supprian, T, Hofmann, E, Warmuth-Metz, M, Franzek, E, Becker, T, Pfefferbaum, A, Sullivan, EV, Hedehus, M, Moseley, M, Lim, KO, Mandl, RC, Schnack, HG, Luigjes, J, al., E, Mandl, RC, Pasternak, O, Cahn, W, al., E, Bagary, MS, Symms, MR, Barker, GJ, Mutsatsa, SH, Joyce, EM, Ron, MA, Foong, J, Maier, M, Barker, GJ, Brocklehurst, S, Miller, DH, Ron, MA, Foong, J, Symms, MR, Barker, GJ, al., E, Kubicki, M, Park, H, Westin, CF, al., E, Bagary, MS, Foong, J, Maier, M, al., E, Pasternak, O, Westin, CF, Bouix, S, Pasternak, O, Westin, CF, Dahlben, B, Bouix, S, Kubicki, M, Oestreich, LK, Pasternak, O, Shenton, ME, al., E, Amato, D, Beasley, CL, Hahn, MK, Vernon, AC, Vernon, AC, Natesan, S, Modo, M, Kapur, S, Mondelli, V, Reininghaus, U, Kempton, MJ, Valmaggia, L, al., E, Baumeister, D, Lightman, SL, Pariante, CM, Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A, Baumeister, D, Akhtar, R, Ciufolini, S, Pariante, CM, Mondelli, V, Meyer, U, Vernon, AC, So, PW, Lythgoe, DJ, al., E, Cotel, MC, Lenartowicz, EM, Natesan, S, al., E, Mondelli, V, Anacker, C, Vernon, AC, al., E, Calcia, MA, Bonsall, DR, Bloomfield, PS, Selvaraj, S, Barichello, T, Howes, OD, Burke, NN, Fan, CY, Trang, T, McMahon, SB, Russa, F L, Bennett, DL, Püntener, U, Booth, SG, Perry, VH, Teeling, JL, Hahn, YK, Podhaizer, EM, Farris, SP, Miles, MF, Hauser, KF, Knapp, PE, Notter, T, Coughlin, JM, Gschwind, T, al., E, Varga, B, Markó, K, Hádinger, N, al., E, Cattaneo, A, Ferrari, C, Uher, R, al., E, Mondelli, V, Ciufolini, S, Belvederi, M M, al., E, Sandiego, CM, Gallezot, JD, Pittman, B, al., E, Weber, MD, Godbout, JP, Sheridan, JF, Raison, CL, Rutherford, RE, Woolwine, BJ, al., E, Möller, T, Boddeke, HW, O'Connor, JC, Lawson, MA, André, C, al., E, Hinwood, M, Morandini, J, Day, TA, Walker, FR, Möller, T, Bard, F, Bhattacharya, A, al., E, Pae, CU, Marks, DM, Han, C, Patkar, AA, Oya, K, Kishi, T, Iwata, N, Baumeister, D, Ciufolini, S & Mondelli, V 2016, ' Brain microglia in psychiatric disorders ', Lancet psychiatry, vol. 0, no. 0, pp. 587-597 . https://doi.org/10.1016/S2215-0366(17)30101-3

SummaryThe role of immune activation in psychiatric disorders has attracted considerable attention over the past two decades, contributing to the rise of a new era for psychiatry. Microglia, the macrophages of the brain, are progressively becoming th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1698f7e9b3eca5ef43eb16cacb00b091
https://research.vumc.nl/en/publications/07f168d1-2b4d-4483-b9b1-1659ff4e83f8

ACR Appropriateness Criteria®on Suspected Osteomyelitis in Patients With Diabetes Mellitus

Autor: Schweitzer, ME, Daffner, RH, Weissman, BN, Bennett, DL, Blebea, JS, Jacobson, JA, Morrison, WB, Resnik, CS, Roberts, CC, Rubin, DA, Seeger, LL, Taljanovic, M, Wise, JN, Payne, WK

Publikováno v: Schweitzer, ME; Daffner, RH; Weissman, BN; Bennett, DL; Blebea, JS; Jacobson, JA; et al.(2008). ACR Appropriateness Criteria®on Suspected Osteomyelitis in Patients With Diabetes Mellitus. Journal of the American College of Radiology, 5(8), 881-886. doi: 10.1016/j.jacr.2008.05.002. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2gr9d0n8

Imaging of the diabetic foot is among the most challenging areas of radiology. The authors present a consensus of the suggested tests in several clinical scenarios, such as early neuropathy, soft-tissue swelling, skin ulcer, and suspected osteomyelit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::7833f6d9c9dfe66a0d0fbe2e16cc84ec
http://www.escholarship.org/uc/item/2gr9d0n8