Zobrazeno 1 - 10 of 15 pro vyhledávání: '"BENJAMIN A. KUGLER"'
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Akademický článek
Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice
Autor: Benjamin A. Kugler, Jared Lourie, Nicolas Berger, Nana Lin, Paul Nguyen, Edzana DosSantos, Abir Ali, Amira Sesay, H. Grace Rosen, Baby Kalemba, Gregory M. Hendricks, Joseph A. Houmard, Hiromi Sesaki, Philimon Gona, Tongjian You, Zhen Yan, Kai Zou
Publikováno v: Molecular Metabolism, Vol 77, Iss , Pp 101802- (2023)
Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine
Externí odkaz: https://doaj.org/article/2a6dac4c2dd4468298c7721d261959bb
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2
Akademický článek
Pharmacological inhibition of dynamin‐related protein 1 attenuates skeletal muscle insulin resistance in obesity
Autor: Benjamin A. Kugler, Wenqian Deng, Abigail L. Duguay, Jessica P. Garcia, Meaghan C. Anderson, Paul D. Nguyen, Joseph A. Houmard, Kai Zou
Publikováno v: Physiological Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)
Abstract Dynamin‐related protein‐1 (Drp1) is a key regulator in mitochondrial fission. Excessive Drp1‐mediated mitochondrial fission in skeletal muscle under the obese condition is associated with impaired insulin action. However, it remains un
Externí odkaz: https://doaj.org/article/9018d41bf3c545d48e4a58dd5405a204
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3
Sexually dimorphic hepatic mitochondrial adaptations to exercise: a mini-review
Autor: Benjamin A. Kugler, John P. Thyfault, Colin S. McCoin
Publikováno v: Journal of Applied Physiology. 134:685-691
Exercise is a physiological stress that disrupts tissue and cellular homeostasis while enhancing systemic metabolic energy demand mainly through the increased workload of skeletal muscle. Although the extensive focus has been on skeletal muscle adapt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4baa468d3acb92c8dc6e0fe1346aa945
https://doi.org/10.1152/japplphysiol.00711.2022
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4
148-OR: Partial Knockout of Skeletal Muscle Dynamin-Related Protein 1 Improves Insulin Sensitivity in Diet-Induced Insulin Resistant Mice, but Not in Normal Control Mice
Autor: BENJAMIN A. KUGLER, NANA LIN, PAUL D. NGUYEN, ABIR ALI, AMIRA SESAY, BABY LENGA KALEMBA, HIROMI SESAKI, KAI ZOU
Publikováno v: Diabetes. 71
Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported excessive Drp1 activity in skeletal muscle from both animals and humans with insulin resistance, which is strongly correlated to impaired skel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ceed77bf52c8eddd08cb969285b69f1
https://doi.org/10.2337/db22-148-or
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5
Impaired glucose partitioning in primary myotubes from severely obese women with type 2 diabetes
Autor: Pamela J. Hornby, J. Matthew Hinkley, Donghai Zheng, Walter J. Pories, Benjamin A. Kugler, James Lenhard, G. Lynis Dohm, Kai Zou, Terry E. Jones, Kristen Turner, Joseph A. Houmard
Publikováno v: Am J Physiol Cell Physiol
The purpose of this study was to determine whether intramyocellular glucose partitioning was altered in primary human myotubes derived from severely obese women with type 2 diabetes. Human skeletal muscle cells were obtained from lean nondiabetic and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d599115bacd5dc9a3b83a49e4e3307b5
https://doi.org/10.1152/ajpcell.00157.2020
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7
Roux-en-Y gastric bypass surgery restores insulin-mediated glucose partitioning and mitochondrial dynamics in primary myotubes from severely obese humans
Autor: Junhan Li, Philimon Gona, Kai Zou, Anders E. Gundersen, Joseph A. Houmard, Nancy Eugene, Wenqian Deng, Benjamin A. Kugler
Publikováno v: International journal of obesity (2005)
Background/Objectives: Impaired insulin-mediated glucose partitioning is an intrinsic metabolic defect in skeletal muscle from severely obese humans (BMI ≥ 40 kg/m2). Roux-en-Y gastric bypass (RYGB) surgery has been shown to improve glucose metabol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9d5834e740834a566aa9f375b688da
https://doi.org/10.1038/s41366-019-0469-y
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8
Pharmacological inhibition of dynamin‐related protein 1 attenuates skeletal muscle insulin resistance in obesity
Autor: Paul Nguyen, Jessica P. Garcia, Joseph A. Houmard, Meaghan Anderson, Abigail L. Duguay, Kai Zou, Wenqian Deng, Benjamin A. Kugler
Publikováno v: Physiological Reports
Physiological Reports, Vol 9, Iss 7, Pp n/a-n/a (2021)
Dynamin‐related protein‐1 (Drp1) is a key regulator in mitochondrial fission. Excessive Drp1‐mediated mitochondrial fission in skeletal muscle under the obese condition is associated with impaired insulin action. However, it remains unknown whe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b89b1652b951afa27ac8a3e0e363eb6
https://doi.org/10.14814/phy2.14808
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