Zobrazeno 1 - 10
of 1 380
pro vyhledávání: '"BECN1"'
Autor:
Shuxin Li, Jianyi Lv, Zhihui Li, Qiuyu Zhang, Jing Lu, Xueyun Huo, Meng Guo, Xin Liu, Changlong Li, Jinghui Wang, Hanping Shi, Li Deng, Zhenwen Chen, Xiaoyan Du
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Background Small cell lung cancer (SCLC) stands as one of the most lethal malignancies, characterized by a grim diagnosis and prognosis. The emergence of multi-drug resistance poses a significant hurdle to effective therapy. Although previou
Externí odkaz:
https://doaj.org/article/25fbaf0b7bc643e89182ec06d110b3f0
Autor:
Chenggong Zeng, Zhuoran Li, Zhiqing Wei, Tingting Chen, Juan Wang, Junting Huang, Feifei Sun, Jia Zhu, Suying Lu, Zijun Zhen
Publikováno v:
Cancer Reports, Vol 7, Iss 10, Pp n/a-n/a (2024)
ABSTRACT Background The prognosis of high‐risk neuroblastomas (NB) that are resistant to first‐line induction chemotherapy is relatively poor. This study explored the mechanism of resistance to first‐line chemotherapeutics mediated by TXNDC17 a
Externí odkaz:
https://doaj.org/article/89a7ccb521774d3e8a4eaf5e8bcb8d74
Autor:
Xiaohui Hua, Daimin Xiang, Jiheng Xu, Shouyue Zhang, Shuai Wu, Zhongxian Tian, Junlan Zhu, Chuanshu Huang
Publikováno v:
Translational Oncology, Vol 51, Iss , Pp 102178- (2025)
Isorhapontigenin (ISO), an active compound isolated from the Chinese herb Gnetum Cleistostachyum, exhibited strong preventive and therapeutic effects on bladder cancer (BC) both in vitro and in vivo. Our previous studies revealed that ISO-induced aut
Externí odkaz:
https://doaj.org/article/a3d43bd726ba47678b8a1f6ddd91bd90
Autor:
Silvia Vega-Rubin-de-Celis
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
ABSTRACTBECN1 (BCL2 interacting myosin like coiled protein) is a major regulator of autophagy and a haploinsufficient tumor suppressor. BECN1 binds to multiple proteins and it is part of at least two different class III phosphatidylinositol (PI) 3 Ki
Externí odkaz:
https://doaj.org/article/b9fc0219a5354e0e93b93cd82015f9db
Publikováno v:
European Journal of Medical Research, Vol 28, Iss 1, Pp 1-13 (2023)
Abstract Recently, evidence has suggested a regulatory role for SND1 in osteoarthritis progression. Interestingly, we found that SND1 protein expression was increased, mitochondria were shrunken and decreased in number, mitochondrial membrane potenti
Externí odkaz:
https://doaj.org/article/fdda41c63e594b2d9f7ed07eba657f66
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 7, Pp 1104-1109 (2023)
Objective To analyze the effect of down-regulation of BECN1 on the proliferation,invasion and migration of human leukemia cell line THP-1,and to explore its potential molecular mechanism. Methods The lentivirus expressing shRNA targeting at BECN1 and
Externí odkaz:
https://doaj.org/article/ee1ae8bac24341d9b226925ede9dd8c7
Autor:
Elez-Burnjaković Nikolina, Pojskić Lejla, Haverić Anja, Lojo-Kadrić Naida, Omanović Maida Hadžić, Ramić Jasmin, Smajlović Ajla, Maksimović Milka, Haverić Sanin
Publikováno v:
Arhiv za Higijenu Rada i Toksikologiju, Vol 74, Iss 1, Pp 16-21 (2023)
Anti-proliferative effects of halogenated boroxine – K2(B3O3F4OH) (HB) – have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown. This study aimed to determine its cytotoxic effect
Externí odkaz:
https://doaj.org/article/d247eca450104e30b86b868e61451f72
Autor:
Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou, Guohui Liu
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effects on maintaining bo
Externí odkaz:
https://doaj.org/article/9b0c3cb161884ea89def5bd4e8bd2e22
Autor:
Ali Mirzaei, Farzaneh Fazeli
Publikováno v:
Cellular, Molecular and Biomedical Reports, Vol 2, Iss 3, Pp 129-137 (2022)
Autophagy is an effective regulatory process for eliminating tumors and worn-out intracellular components. Different groups of enzymes and regulatory elements are involved in the autophagy process. MAP1LC3A and BECN1 genes are the most important gene
Externí odkaz:
https://doaj.org/article/56416ea35cea4e158b8ad6fd91075b06
Autor:
Fenfen Yu, Congyao Wang, Yihua Su, Tingting Chen, Wenhui Zhu, Xia Dong, Wanyi Ke, Leqi Cai, Shasha Yang, Pengxia Wan
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundDiabetic retinopathy (DR) is deemed a microangiopathy and neurodegenerative disorder, which is a primary reason of visual impairment in the world. Ferritinophagy is a critical regulator of ferroptosis and has a vital part in the etiopathoge
Externí odkaz:
https://doaj.org/article/335c8b0d5a0a4f7aa7eace330416cb25