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Akademický článek

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M 4 Muscarinic Acetylcholine Receptor.

Autor: Butler CR; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Popiolek M; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., McAllister LA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., LaChapelle EA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Kramer M; Medicine Design, Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States., Beck EM; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Mente S; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Brodney MA; Medicine Design, Medicinal Chemistry, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Brown M; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Gilbert A; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Helal C; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Ogilvie K; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Starr J; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Uccello D; Medicine Design, Medicinal Chemistry, Pfizer Inc., Groton, Connecticut 06340, United States., Grimwood S; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Edgerton J; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Garst-Orozco J; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Kozak R; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Lotarski S; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Rossi A; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., Smith D; Internal Medicine, Pfizer Inc., Cambridge, Massachusetts 02139, United States., O'Connor R; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Lazzaro J; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Steppan C; Discovery Sciences, Primary Pharmacology, Pfizer Inc., Groton, Connecticut 06340, United States., Steyn SJ; Medicine Design, Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, Connecticut 06340, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Jul 11; Vol. 67 (13), pp. 10831-10847. Date of Electronic Publication: 2024 Jun 18.

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Akademický článek

Head injuries related to bicycle collisions and helmet use - an observational study.

Autor: Beck EM; Copenhagen Emergency Medical Services, Ballerup, Denmark.; Prehospital Center, Region Zealand, Næstved, Denmark., Wolthers SA; Prehospital Center, Region Zealand, Næstved, Denmark.; Faculty of Clinical Medicine, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark., Blomberg SN; Copenhagen Emergency Medical Services, Ballerup, Denmark.; Prehospital Center, Region Zealand, Næstved, Denmark., Breindahl N; Prehospital Center, Region Zealand, Næstved, Denmark.; Faculty of Clinical Medicine, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark.; Department of Neonatal and Paediatric Intensive Care, Copenhagen University Hospital, Denmark Rigshospitalet, Copenhagen, Denmark.; Neurosurgical Department, Copenhagen University Hospital, Denmark Rigshospitalet, København Ø, Denmark., Eskesen V; National Clinical Registries, RKKP, København Ø, Denmark., Lippert F; Copenhagen Emergency Medical Services, Ballerup, Denmark., Christensen HC; Copenhagen Emergency Medical Services, Ballerup, Denmark.; Prehospital Center, Region Zealand, Næstved, Denmark.; Faculty of Clinical Medicine, Copenhagen University Hospital Rigshospitalet, University of Copenhagen, Copenhagen Ø, Denmark.

Publikováno v: Traffic injury prevention [Traffic Inj Prev] 2024; Vol. 25 (8), pp. 1081-1088. Date of Electronic Publication: 2024 Jun 21.

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Akademický článek

Psychometric properties of the Angolan version of the Reflective Functioning Questionnaire - 8 (RFQ-8): An exploratory study.

Autor: Martins, Karina¹, Benedito, Luís¹, Farate, Carlos^1,2,3, Daniel, Fernanda^1,4, Testa Vicente, Henrique³ henrique.t.vicente@gmail.com

Publikováno v: Análise Psicológica. 2023, Vol. 41 Issue 2, p235-251. 17p.

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Akademický článek

Reading between the Beats: A Curious Case of Increased Periodic Breathing.

Autor: Setteducato ML; Department of Internal Medicine, College of Medicine, University of Florida, Gainesville, Florida; and.; Division Of Pulmonary, Critical Care and Sleep Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida., Beck EM; Division Of Pulmonary, Critical Care and Sleep Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida., Hadigal S; Department of Internal Medicine, College of Medicine, University of Florida, Gainesville, Florida; and.; Division Of Pulmonary, Critical Care and Sleep Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida.

Publikováno v: Annals of the American Thoracic Society [Ann Am Thorac Soc] 2023 Nov; Vol. 20 (11), pp. 1659-1661.

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Akademický článek

Alveolar macrophages from EVALI patients and e-cigarette users: a story of shifting phenotype.

Autor: Warren KJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA. kristi.warren@hsc.utah.edu.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA. kristi.warren@hsc.utah.edu., Beck EM; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA., Callahan SJ; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA., Helms MN; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA., Middleton E; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA., Maddock S; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.; Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, 80206, USA., Carr JR; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Harris D; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Blagev DP; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Lanspa MJ; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Brown SM; Intermountain Healthcare, Department of Pulmonary & Critical Care Medicine, Murray, UT, 84107, USA., Paine R 3rd; Department of Internal Medicine, Division of Pulmonary & Critical Care Medicine, University of Utah, Salt Lake City, UT, 84132, USA.; George E. Wahlen VA Medical Center, 500 Foothill Dr, Salt Lake City, UT, 84148, USA.

Publikováno v: Respiratory research [Respir Res] 2023 Jun 17; Vol. 24 (1), pp. 162. Date of Electronic Publication: 2023 Jun 17.

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