Zobrazeno 1 - 10
of 2 026
pro vyhledávání: '"BCR-ABL1"'
Publikováno v:
Pharmaceutical Science Advances, Vol 2, Iss , Pp 100052- (2024)
Chronic myeloid leukemia (CML) is the chronic proliferation of myeloid-lineage cells in hematopoietic stem cells driven by the BCR-ABL1 fusion oncoprotein. The development of tyrosine kinase inhibitors (TKIs) has revolutionized CML treatment; however
Externí odkaz:
https://doaj.org/article/f84d99512dd84b1a90409e29b82d0241
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Philadelphia chromosome-positive acute lymphoblastic leukemia (PH + ALL) is the most common cytogenetic abnormality of B-ALL in adults and is associated with poor prognosis. Previously, the only curative treatment option in PH + ALL was allogeneic he
Externí odkaz:
https://doaj.org/article/2ab941d870f746c88dd5fc72bb30c9d3
Autor:
Valentin Garcia-Gutierrez, Fei Huang, Ajibade Ashaye, Mehul Dalal, Victor Laliman-Khara, Massimo Breccia, Megan Rutherford, Hoora Moradian, Petros Patos, Elias Joseph Jabbour
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundPonatinib and asciminib are approved for third-line therapy in chronic-phase chronic myeloid leukemia (CP-CML) and are the only drugs approved for patients with the T315I mutation in the United States. In Europe, only ponatinib is approved
Externí odkaz:
https://doaj.org/article/ed2b0ee3852f4e13af5b8674b7755ddf
Autor:
Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi, Mikael Sommarin, Shamit Soneji, Henrik Hjorth-Hansen, Satu Mustjoki, Johan Richter, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
eLife, Vol 12 (2024)
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of
Externí odkaz:
https://doaj.org/article/d2afc990e3264278aae9d3f9ec4607bc
Autor:
Brittany Salter, Sarah Ge, Amy Tam, Suzanne Demczuk, Darci Butcher, Elizabeth McCready, Dina Khalaf
Publikováno v:
eJHaem, Vol 5, Iss 3, Pp 607-615 (2024)
Abstract A distinct subset of acute myeloid leukemia (AML) is characterized by the presence of the Philadelphia chromosome (Ph+), due to reciprocal translocation t(9;22)(q34;q11.2). This chromosomal rearrangement leads to the fusion of the breakpoint
Externí odkaz:
https://doaj.org/article/6fee930a1c4043ce95ffd04f307d1342
Autor:
Atreye Majumdar, Rahul Katara, Avshesh Mishra, Aastha Gupta, Deepak K. Sharma, Aman K. Srivastava, Shivani Sharma, Ankita Jaiswal, Mallika Dixit, Vipin Kumar, Sachin Kumar, Varun Kumar, Rahul Sharma, Sambit K. Mohanty
Publikováno v:
South Asian Journal of Cancer, Vol 13, Iss 02, Pp 132-141 (2024)
Externí odkaz:
https://doaj.org/article/6fe30c4527e5439182016c2bc9acb9df
Autor:
Xiaozhuo Yu, Wen Zhou, Xiaodong Chen, Shunyu He, Mengting Qin, Meng Yuan, Yang Wang, Woodvine Otieno Odhiambo, Yinsha Miao, Yanhong Ji
Publikováno v:
eLife, Vol 12 (2024)
The evolutionary conservation of non-core RAG regions suggests significant roles that might involve quantitative or qualitative alterations in RAG activity. Off-target V(D)J recombination contributes to lymphomagenesis and is exacerbated by RAG2’ C
Externí odkaz:
https://doaj.org/article/c13616c0d0c14706b4c80c3f8f600e84
Autor:
Vera Vysochinskaya, Olesya Dovbysh, Andrey Gorshkov, Alexandra Brodskaia, Michael Dubina, Andrey Vasin, Yana Zabrodskaya
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 644 (2024)
Chronic myeloid leukemia (CML) is an oncological myeloproliferative disorder that accounts for 15 to 20% of all adult leukemia cases. The molecular basis of this disease lies in the formation of a chimeric oncogene BCR–ABL1. The protein product of
Externí odkaz:
https://doaj.org/article/147c8723f08b4e5ca88de0ede1cd7be0
Autor:
Alessandro Allegra, Giuseppe Mirabile, Santino Caserta, Fabio Stagno, Sabina Russo, Giovanni Pioggia, Sebastiano Gangemi
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 461 (2024)
The balanced reciprocal translocation t (9; 22) (q34; q11) and the BCR-ABL fusion gene, which produce p210 bcr-abl protein production with high tyrosine kinase activity, are characteristics of chronic myeloid leukemia, a myeloproliferative neoplasm.
Externí odkaz:
https://doaj.org/article/9b628f17c71141668fb1979e14500522
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTChronic myeloid leukemia (CML) is a clonal myeloproliferative growth of human pluripotent stem cells which is estimated to occur at a rate of 1/100000 populations every year worldwide. A characteristic feature of this disease is the presence
Externí odkaz:
https://doaj.org/article/2a177b48c86649998aa2237743ada832