Zobrazeno 1 - 10
of 6 124
pro vyhledávání: '"BCL-XL"'
Publikováno v:
Radiation Medicine and Protection, Vol 5, Iss 2, Pp 90-99 (2024)
Objective: To investigate the role and the molecular mechanisms of apoptotic signaling in ferroptosis to regulate tumor radiosensitivity. Methods: Reactive oxygen species (ROS) and lipid peroxide levels were detected in Mouse embryonic fibroblasts(ME
Externí odkaz:
https://doaj.org/article/3074d39f388f458abbcf6579981a4017
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100199- (2024)
Apoptosis plays a significant role in both carcinogenesis and cancer treatment. Apoptotic dysfunction may allow cancer cells to survive. Overexpression of anti-apoptotic B cell lymphoma-2 (BCL-2) family protein members is predicted to majorly contrib
Externí odkaz:
https://doaj.org/article/177b8fd905b94f55bd2515525fed8379
Autor:
Toshihide Kashihara, Yui Morita, Misaki Hatta, Sae Inoue, Yume Suzuki, Akane Morita, Tsutomu Nakahara
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Retinal neurodegeneration, characterized by retinal ganglion cell (RGC) death, is a leading cause of vision impairment and loss in blind diseases, such as glaucoma. Müller cells play crucial roles in maintaining retinal homeostasis. Thus, dysfunctio
Externí odkaz:
https://doaj.org/article/f4d644ad0fb846d1ac05bafd466096ed
Autor:
Yumin Wei, Liping Zhang, Chao Wang, Zefeng Li, Mingjie Luo, Guomin Xie, Xingjiu Yang, Mengyuan Li, Shuyue Ren, Dongbing Zhao, Ran Gao, Jia‐Nan Gong
Publikováno v:
Animal Models and Experimental Medicine, Vol 6, Iss 3, Pp 245-254 (2023)
Abstract Background New therapeutic targets are needed to improve the outcomes for gastric cancer (GC) patients with advanced disease. Evasion of programmed cell death (apoptosis) is a hallmark of cancer cells and direct induction of apoptosis by tar
Externí odkaz:
https://doaj.org/article/d2b8ee01811642c5933027640e7981fe
Publikováno v:
Cancer Reports, Vol 7, Iss 4, Pp n/a-n/a (2024)
Abstract Introduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence. Certain
Externí odkaz:
https://doaj.org/article/4361c3d3eb3f44e6a06b7bd4b368f7e2
Autor:
Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We
Externí odkaz:
https://doaj.org/article/3f533fcbf74447e289791076e3a6c8ea
Autor:
S. V. Ziablitsev, V. V. Vodianyk
Publikováno v:
Journal of Ophthalmology, Iss 5, Pp 34-40 (2023)
Background: It is important to develop orbital hydrogel implants capable of depositing drugs (particularly, antimicrobial and anticancer drugs). Purpose: To assess antimicrobial effects of hybrid hydrogel implants containing gold nanoparticles and
Externí odkaz:
https://doaj.org/article/cd19698766724e68833518bba8ae0096
Autor:
Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero, Donatella Del Bufalo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background Macrophages take center stage in the tumor microenvironment, a niche composed of extracellular matrix and a heterogeneous group of cells, including immune ones. They can evolve during tumor progression and acquire Tumor-Associated
Externí odkaz:
https://doaj.org/article/02fb70e5bdc54afba99e40eb573df8e0
Autor:
Ibrahim Damilare Boyenle, Abdeen Tunde Ogunlana, Abdul-Quddus Kehinde Oyedele, Babatunde Kazeem Olokodana, Nurudeen Owolabi, Abdulmalik Salahudeen, Oluwafemi Timothy Aderenle, Taiwo Oluwafisayomi Oloyede, Temitope Isaac Adelusi, PhD
Publikováno v:
Journal of Taibah University Medical Sciences, Vol 18, Iss 3, Pp 461-469 (2023)
الملخص: أهداف البحث: في حين أن التوازن الدقيق في أفراد الأسرة المؤيدة للاستماتة والمضاد للاستماتة من عائلة بروتين الخلايا البائية 2 (بي سي
Externí odkaz:
https://doaj.org/article/e3080b9a970b4680892703113f379063