Computational modeling of human-nCoV protein-protein interaction network

Autor: Sovan Saha, Anup Kumar Halder, Soumyendu Sekhar Bandyopadhyay, Piyali Chatterjee, Mita Nasipuri, Subhadip Basu

Publikováno v: Methods (San Diego, Calif.)

COVID-19 has created a global pandemic with high morbidity and mortality in 2020. Novel coronavirus (nCoV), also known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), is responsible for this deadly disease. International Committee on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435738567e38baa1d7949ee2f9bf8d03
https://doi.org/10.1016/j.ymeth.2021.12.003

Investigation of sugar binding kinetics of the E. coli sugar/H+ symporter XylE using solid-supported membrane-based electrophysiology

Autor: Andre Bazzone, Laura Tesmer, Derya Kurt, H. Ronald Kaback, Klaus Fendler, M. Gregor Madej

Publikováno v: The Journal of Biological Chemistry

Bacterial transporters are difficult to study using conventional electrophysiology because of their low transport rates and the small size of bacterial cells. Here, we applied solid-supported membrane–based electrophysiology to derive kinetic param

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173ab5f163d13e9c80e23eacd2a83eef
http://europepmc.org/articles/PMC8784342

Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease

Autor: Xueqin Bai, Quanquan Gu, Xiaojun Guan, Ting Gao, Min Xuan, Baorong Zhang, Luyan Gu, Minming Zhang, Jingjing Wu, Xiaocao Liu, Cheng Zhou, Tao Guo, Peiyu Huang, Xiaojun Xu

Publikováno v: NeuroImage : Clinical
NeuroImage: Clinical, Vol 32, Iss, Pp 102873-(2021)

Highlights • LC degeneration associated with cognitive decline in PD patients. • LC degeneration correlated with extensive network disruption. • LC degeneration may contribute to cognitive decline through disorganized brain function.
Degen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd7bdbf77640baf8c28a6cc706183b5
https://doi.org/10.1016/j.nicl.2021.102873

A rice protein interaction network reveals high centrality nodes and candidate pathogen effector targets.

Autor: Mishra B; Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA., Kumar N; Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA., Shahid Mukhtar M; Department of Biology, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA.; Nutrition Obesity Research Center, University of Alabama at Birmingham, 1300 University Blvd., Birmingham, AL 35294, USA.; General Surgery Gastrointestinal Section, Department of Surgery, UAB School of Medicine, Birmingham, AL 35294, USA.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2022 Apr 21; Vol. 20, pp. 2001-2012. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).

Machine learning and deep learning methods that use omics data for metastasis prediction.

Autor: Albaradei S; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; King Abdulaziz University, Faculty of Computing and Information Technology, Jeddah, Saudi Arabia., Thafar M; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Taif University, Collage of Computers and Information Technology, Taif, Saudi Arabia., Alsaedi A; King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; King Abdulaziz Medical City, Jeddah, Saudi Arabia., Van Neste C; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Gojobori T; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.; Biological and Environmental Sciences and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Essack M; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia., Gao X; Computational Bioscience Research Center (CBRC), Computer, Electrical and Mathematical Sciences and Engineering Division (CEMSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Publikováno v: Computational and structural biotechnology journal [Comput Struct Biotechnol J] 2021 Sep 04; Vol. 19, pp. 5008-5018. Date of Electronic Publication: 2021 Sep 04 (Print Publication: 2021).