Zobrazeno 1 - 10
of 419
pro vyhledávání: '"BBB, blood‒brain barrier"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Due to considerable global prevalence and high recurrence rate, the pursuit of effective new medication for epilepsy treatment remains an urgent and significant challenge. Drug repurposing emerges as a cost-effective and efficient strategy t
Externí odkaz:
https://doaj.org/article/6072d3afeb984bc18714a61c88c0727a
Publikováno v:
Medicina, Vol 60, Iss 9, p 1384 (2024)
Nanomedicine is a newer, promising approach to promote neuroprotection, neuroregeneration, and modulation of the blood–brain barrier. This review includes the integration of various nanomaterials in neurological disorders. In addition, gelatin-base
Externí odkaz:
https://doaj.org/article/1561e497fadb448eab4823bdc5f9614c
Akademický článek
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Autor:
Amod Kulkarni, Evelína Mochnáčová, Petra Majerova, Ján Čurlík, Katarína Bhide, Patrícia Mertinková, Mangesh Bhide
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Neisseria adhesin A (NadA), one of the surface adhesins of Neisseria meningitides (NM), interacts with several cell types including human brain microvascular endothelial cells (hBMECs) and play important role in the pathogenesis. Receptor binding poc
Externí odkaz:
https://doaj.org/article/84acc2e2a9574b5a8d0bed4180cf5b68
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Amyloid β (Aβ) in brain parenchyma is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). Aβ is transported from the brain to the plasma via complex transport mechanisms at the blood-brain barrier (BBB). About 90–95%
Externí odkaz:
https://doaj.org/article/20882e9df475467ba5483c27414d313a
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6490-6504 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6490-6504 (2021)
Graphical abstract
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression. Unfortunately, ABCA7 belongs to the
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression. Unfortunately, ABCA7 belongs to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c495bacbe4f6d5dd1686380857969678
http://europepmc.org/articles/PMC8666613
http://europepmc.org/articles/PMC8666613
Autor:
Zhongyi Ma, Miao-Miao Niu, Tong Yan, Liting Cheng, Kexin Huang, Xin Zhong, Ling Yang, Chong Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3220-3230 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
As a typical human pathogenic fungus, Cryptococcus neoformans is a life-threatening invasive fungal pathogen with a worldwide distribution causing ∼700,000 deaths annually. Cryptococcosis is not just an infection with multi-organ involvement, intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec61dfe7e1d8ece9d45d779c2cca95
http://www.sciencedirect.com/science/article/pii/S221138352100160X
http://www.sciencedirect.com/science/article/pii/S221138352100160X
Autor:
Lu Feng, Kai Zhang, Bo Liu, Tingting Jiang, Liang Ouyang, Guan Wang, Jiamei Li, Shiou Zhu, Junping Pei
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3015-3034 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Parkinson's disease (PD), known as one of the most universal neurodegenerative diseases, is a serious threat to the health of the elderly. The current treatment has been demonstrated to relieve symptoms, and the discovery of new small-molecule compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12dab43aca56bfd6a912c2aa71297ff
http://www.sciencedirect.com/science/article/pii/S2211383521000642
http://www.sciencedirect.com/science/article/pii/S2211383521000642
Autor:
Liang Han, Chen Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs, resulting in ineffective drug therapy of brain diseases. However, during the onset and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5b
http://www.sciencedirect.com/science/article/pii/S2211383520308522
http://www.sciencedirect.com/science/article/pii/S2211383520308522