Citrobacter rodentium possesses a functional type II secretion system necessary for successful host infection

Autor: Z Krekhno, SE Woodward, A Serapio-Palacios, J Peña-Díaz, KM Moon, LJ Foster, BB Finlay

Publikováno v: Gut Microbes, Vol 16, Iss 1 (2024)

ABSTRACTInfectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections these pathogens employ a plethora of virulence fa

Externí odkaz: https://doaj.org/article/accdb1c181bb46dab57b01ce5e45dde3

Fecal microbiota transplantation from protozoa-exposed donors downregulates immune response in a germ-free mouse model, its role in immune response and physiology of the intestine.

Autor: Partida-Rodríguez O; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico.; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Brown EM; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Woodward SE; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Cirstea M; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Reynolds LA; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada.; Department of Biochemistry and Microbiology, Faculty of Science, University of Victoria, Victoria, Canada., Petersen C; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Vogt SL; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Peña-Díaz J; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Thorson L; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada., Arrieta MC; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Canada., Hernández EG; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Rojas-Velázquez L; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Moran P; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., González Rivas E; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Serrano-Vázquez A; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Pérez-Juárez H; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Torres J; Unidad de Investigación en Enfermedades Infecciosas y Parasitarias, Instituto Mexicano del Seguro Social (IMSS), Mexico, Mexico., Ximénez C; Unidad de Investigación en Medicina Experimental, Hospital General de Mexico, Universidad Nacional Autónoma de México, Mexico, Mexico., Finlay BB; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada.; Department of Microbiology and Immunology, Faculty of Science, University of British Columbia, Vancouver, Canada.; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Publikováno v: PloS one [PLoS One] 2024 Oct 28; Vol. 19 (10), pp. e0312775. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).

Secretory IgA in breast milk protects against asthma through modulation of the gut microbiota.

Autor: Donald K; Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Serapio-Palacios A; Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Gerbec Z; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada., Bozorgmehr T; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Holani R; Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Cruz AR; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Laboratory of Host-Microbiota Interaction, 75015 Paris, France., Schnupf P; Université Paris Cité, INSERM UMR-S1151, CNRS UMR-S8253, Institut Necker Enfants Malades, Laboratory of Host-Microbiota Interaction, 75015 Paris, France., Finlay BB; Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address: bfinlay@msl.ubc.ca.

Publikováno v: Cell reports [Cell Rep] 2024 Oct 22; Vol. 43 (10), pp. 114835. Date of Electronic Publication: 2024 Oct 04.

Metagenomic Analysis Reveals Large-Scale Disruptions of the Gut Microbiome in Parkinson's Disease.

Autor: Metcalfe-Roach A; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada., Cirstea MS; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada., Yu AC; Pacific Parkinson's Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Ramay HR; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Coker O; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Boroomand S; Borgland Family Brain Tissue and DNA Bank, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Kharazyan F; Borgland Family Brain Tissue and DNA Bank, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada., Martino D; Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada., Sycuro LK; International Microbiome Centre, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada., Appel-Cresswell S; Pacific Parkinson's Research Centre, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.; Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Finlay BB; Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

Publikováno v: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Oct; Vol. 39 (10), pp. 1740-1751. Date of Electronic Publication: 2024 Aug 28.

The potential importance of the built-environment microbiome and its impact on human health.

Autor: Bosch TCG; Zoological Institute, University of Kiel, Kiel 24118, Germany.; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada., Wigley M; Graduate School of Architecture, Planning and Preservation, Columbia University, New York, NY 10027., Colomina B; School of Architecture, Princeton University, Princeton, NJ 08544., Bohannan B; The Institute of Ecology and Evolution, University of Oregon, Eugene, OR 97403-5289., Meggers F; Princeton University School of Architecture & Andlinger Center for Energy and the Environment, Princeton, NJ 08540., Amato KR; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, Northwestern University, Evanston, IL 60208., Azad MB; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3E 0Z3, Canada.; Department of Community Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P5, Canada., Blaser MJ; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Children's Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada.; Center for Advanced Biotechnology and Medicine at Rutgers Biomedical and Health Sciences, Rutgers University, Piscataway, NJ 08854-8021., Brown K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Program in Science, Technology and Society, Massachusetts Institute of Technology, Cambridge, MA 02139., Dominguez-Bello MG; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901.; Department of Anthropology, Rutgers University, New Brunswick, NJ 08901., Ehrlich SD; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Institute of Neurology, University College London, London WC1N 3RX, United Kingdom., Elinav E; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Systems Immunology Department, Weizmann Institute of Science, Rehovot 761000, Israel.; Division of Microbiome & Cancer, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany., Finlay BB; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Geddie K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Medical and Related Sciences Centre, The Canadian Institute for Advanced Research, Toronto, ON M5G 1L7, Canada., Geva-Zatorsky N; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Technion Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525433, Israel.; Department of Cell Biology and Cancer Science, Technion-Israel Institute of Technology, Haifa 3525433, Israel., Giles-Vernick T; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Anthropology & Ecology of Disease Emergence, Institut Pasteur, Université Paris Cité, Paris 75015, France., Gros P; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada., Guillemin K; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403., Haraoui LP; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Microbiology and Infectious Diseases, Université de Sherbrooke, Canada J1E 4K8., Johnson E; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; College of Human Ecology, Cornell University, Ithaka NY 14853., Keck F; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Laboratoire d'Anthropologie Sociale, Collège de France, Paris 75005, France., Lorimer J; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; School of Geography and the Environment, University of Oxford, OX1 3QY, United Kingdom., McFall-Ngai MJ; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Division of Biology and Biological Engineering, Caltech, Pasadena, CA 91125., Nichter M; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; School of Anthropology, University of Arizona, Tucson, AZ 85721., Pettersson S; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Nanyang Technological University, Singapore 637715, Singapore., Poinar H; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, McMaster University, Hamilton, ON L8S 4M4, Canada., Rees T; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; LIMN, Berkeley, CA 94708., Tropini C; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Microbiology and Immunology and School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada., Undurraga EA; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Escuela de Gobierno, Pontificia Universidad Católica de Chile, Santiago 7820436, Chile., Zhao L; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901., Melby MK; Humans and the Microbiome Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada.; Department of Anthropology, University of Delaware, Newark, DE 19716.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 14; Vol. 121 (20), pp. e2313971121. Date of Electronic Publication: 2024 Apr 25.