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pro vyhledávání: '"BAY K8644"'
Publikováno v:
Journal of Cardiovascular Pharmacology. 77:280-290
Because cardiotoxicity is one of the leading causes of drug failure and attrition, the design of new protocols and technologies to assess proarrhythmic risks on cardiac cells is in continuous development by different laboratories. Current methodologi
Publikováno v:
Angewandte Chemie International Edition. 60:3131-3137
1,4-Dihydropyridines (DHP), the most commonly used antihypertensives, function by inhibiting the L-type voltage-gated Ca2+ (Cav ) channels. DHP compounds exhibit chirality-specific antagonistic or agonistic effects. The structure of rabbit Cav 1.1 bo
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Publikováno v:
Cellular and Molecular Neurobiology. 41:1707-1714
The present study explored the modulating apoptosis effect of hydrogen sulfide (H2S) in subarachnoid hemorrhage (SAH) rats and its exact mechanism. A rat SAH model established by intravascular puncturing was used for the present study. After giving N
Autor:
Joseph M. Miano, Sachin A. Gupte, Igor V. Kizub, Kevin Michael, Petra Rocic, Michael Grzybowski, Atsushi Kitagawa, Christina Jacob, Aron M. Geurts, Rakhee S. Gupte, Julie A. Reisz, Angelo D'Alessandro
Publikováno v:
Hypertension. 76:523-532
Epidemiological studies suggest that individuals in the Mediterranean region with a loss-of-function, nonsynonymous single nucleotide polymorphism (S188F), in glucose-6-phosphate dehydrogenase ( G6pd ) are less susceptible to vascular diseases. Howev
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
The general anesthetic ketamine has been repurposed by physicians as an anti-depressant and by the public as a recreational drug. However, ketamine use can cause extensive pathological changes, including ketamine cystitis. The mechanisms of ketamine
Autor:
Aysegül Temiz Artmann, Till Creutz, Jürgen Hescheler, Julia Falkenstein, Ilya Digel, Gerhard M. Artmann, Robin Bayer
Publikováno v:
Cellular Physiology and Biochemistry, Vol 54, Iss 3, Pp 371-383 (2020)
Background/aims This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to mea
Publikováno v:
American Journal of Physiology-Renal Physiology. 317:F1132-F1141
Voltage-dependent L-type Ca2+channels (L-VDCCs) and the RhoA/Rho kinase pathway are two predominant intracellular signaling pathways that regulate renal microvascular reactivity. Traditionally, these two pathways have been thought to act independentl
Autor:
Muhan Jing, Shanshan Wang, Ding Li, Zeyu Wang, Ziwen Li, Yichen Lu, Tong Sun, Chen Qiu, Fang Chen, Haijuan Yu, Wei Zhang
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Lorcaserin is a serotonergic agonist specific to the 5-hydroxytryptamine 2c receptor (5-HT2CR) that is FDA approved for the long-term management of obesity with or without at least one weight-related comorbidity. Lorcaserin can restrain patients’ a