BAX -248 G>A and BCL2 -938 C>A Variant Lowers the Survival in Patients with Nasopharyngeal Carcinoma and Could be Associated with Tissue-Specific Malignancies: A Multi-Method Approach

Autor: Sandeep Ghatak, Eric Zomawia, Nilanjana Das, Komri Riba, R. Rajendra Reddy, Sudipa Mal, Arindom Chakraborty, Syamantak Mukherjee, Sushil Kumar Sahu, Zoreng puii, Amol Suryawanshi, Nabanita Roy Chattopadhyay, Shanmugam Rajasubramaniam, Tathagata Choudhuri, Yengkhom Indibor Singh, Ashok Kumar Das, Saikat De, Sankar Deb Roy, Koustav Chatterjee, Sam Tsering, Piyanki Das

Publikováno v: Asian Pacific Journal of Cancer Prevention : APJCP

Background: The association of BAX -248 G>A and BCL2 -938 C>A with different cancers created conflicts. We studied the correlation and the effect of these polymorphisms in patients with Nasopharyngeal Carcinoma (NPC). Methods: PCR-RFLP and Sanger seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa1c67867832404434d2a475c9c2152
https://doi.org/10.31557/apjcp.2021.22.4.1171

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver DiseaseSummary

Autor: Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a717cf593f4034226b292cb0ee07cc
http://www.sciencedirect.com/science/article/pii/S2352345X21000254

Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

Autor: Jose J.G. Marin, Maria J. Monte, Malgorzata Milkiewicz, Miren Bravo, Fernando Lopitz-Otsoa, Javier Crespo, Carlos Ferre-Aracil, Sofia Lachiondo-Ortega, Virginia Gutiérrez-de-Juan, Marta Varela-Rey, Jose Luis Calleja, Teresa C. Delgado, María L. Martínez-Chantar, Mercedes Robles, Piotr Milkiewicz, Marina Serrano-Macia, Pablo Fernández-Tussy, Juan Anguita, Marcos López-Hoyos, Shelly C. Lu, David Fernández-Ramos, Naroa Goikoetxea-Usandizaga, Paula Iruzubieta, Natalia Elguezabal, Lucía Barbier-Torres, Jorge Simón, Mercedes Rincon

Publikováno v: JHEP Reports, Vol 3, Iss 3, Pp 100276-(2021)
JHEP Reports Volume 3, Issue 3, June 2021, 100276
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
JHEP Reports

Background & Aims Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260a6a78478feb3a4a8f609b4afaa257
https://pubmed.ncbi.nlm.nih.gov/33997750

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