Zobrazeno 1 - 10
of 419
pro vyhledávání: '"BARRY J. HOFFER"'
Autor:
Man-Hau Ho, Yih-Jeng Tsai, Chia-Yen Chen, Anastasia Yang, Thierry Burnouf, Yun Wang, Yung-Hsiao Chiang, Barry J. Hoffer, Szu-Yi Chou
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-22 (2024)
Abstract Background Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions and exacerbation of early neurodegeneration; the repair of axonal and synaptic structures is critical for re
Externí odkaz:
https://doaj.org/article/a99233fd0b8446cc9e60cc3921f12614
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106563- (2024)
Externí odkaz:
https://doaj.org/article/4a8fdaad6d87422b91427c0a069d7f0b
Autor:
Vicki Wang, Kuan-Yin Tseng, Tung-Tai Kuo, Eagle Yi-Kung Huang, Kuo-Lun Lan, Zi-Rong Chen, Kuo-Hsing Ma, Nigel H. Greig, Jin Jung, Ho-II Choi, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-19 (2024)
Abstract Background Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial
Externí odkaz:
https://doaj.org/article/42e9f0f96ce54c0abdd8d29f68afa314
Autor:
Daniela Lecca, Shih-Chang Hsueh, Weiming Luo, David Tweedie, Dong Seok Kim, Abdul Mannan Baig, Neil Vargesson, Yu Kyung Kim, Inho Hwang, Sun Kim, Barry J. Hoffer, Yung-Hsiao Chiang, Nigel H. Greig
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-21 (2023)
Abstract Background Quelling microglial-induced excessive neuroinflammation is a potential treatment strategy across neurological disorders, including traumatic brain injury (TBI), and can be achieved by thalidomide-like drugs albeit this approved dr
Externí odkaz:
https://doaj.org/article/7c5613a4803945af9101f28f707d2991
Autor:
Elliot J. Glotfelty, Luis B. Tovar-y-Romo, Shih-Chang Hsueh, David Tweedie, Yazhou Li, Brandon K. Harvey, Barry J. Hoffer, Tobias E. Karlsson, Lars Olson, Nigel H. Greig
Publikováno v:
Cells, Vol 12, Iss 10, p 1367 (2023)
Neuroinflammation is a unifying factor among all acute central nervous system (CNS) injuries and chronic neurodegenerative disorders. Here, we used immortalized microglial (IMG) cells and primary microglia (PMg) to understand the roles of the GTPase
Externí odkaz:
https://doaj.org/article/92ddbaddb19c409ea44ce0d43af5de5a
Autor:
Man-Hau Ho, Chia-Hung Yen, Tsung-Hsun Hsieh, Tzu-Jen Kao, Jing-Yuan Chiu, Yung-Hsiao Chiang, Barry J. Hoffer, Wen-Chang Chang, Szu-Yi Chou
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102067- (2021)
Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI induces secondary effects which damage neurons. Ta
Externí odkaz:
https://doaj.org/article/91593b3bc5904dee8b942b464cbec397
Autor:
Miaad Bader, Yazhou Li, Daniela Lecca, Vardit Rubovitch, David Tweedie, Elliot Glotfelty, Lital Rachmany, Hee Kyung Kim, Ho-Il Choi, Barry J. Hoffer, Chaim G. Pick, Nigel H. Greig, Dong Seok Kim
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 439-453 (2019)
Traumatic brain injury (TBI) is a neurodegenerative disorder for which no effective pharmacological treatment is available. Glucagon-like peptide 1 (GLP-1) analogues such as Exenatide have previously demonstrated neurotrophic and neuroprotective effe
Externí odkaz:
https://doaj.org/article/ed22acdb854b481d8687b470984eeda5
Autor:
Shih Chang Hsueh, Michael T. Scerba, David Tweedie, Daniela Lecca, Dong Seok Kim, Abdul Mannan Baig, Yu Kyung Kim, Inho Hwang, Sun Kim, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2449 (2022)
Traumatic brain injury (TBI) is a major risk factor for several neurodegenerative disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). Neuroinflammation is a cause of later secondary cell death following TBI, has the potent
Externí odkaz:
https://doaj.org/article/7363abdad1cd4e2f96aeea1e980c087f
Autor:
Michael K. Ghiam, Shrey D. Patel, Alan Hoffer, Warren R. Selman, Barry J. Hoffer, Michael E. Hoffer
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Traumatic brain injury (TBI) is the most common cause of morbidity among trauma patients; however, an effective pharmacological treatment has not yet been approved. Individuals with TBI are at greater risk of developing neurological illnesses such as
Externí odkaz:
https://doaj.org/article/1b5fb75b58e240389cba482d54dc82c4
Autor:
Seong-Jin Yu, Shuchun Chen, Yung-Yung Yang, Elliot J. Glotfelty, Jin Jung, Hee Kyung Kim, Ho-Il Choi, Doo-Sup Choi, Barry J. Hoffer, Nigel H. Greig, Yun Wang
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
BackgroundWe previously demonstrated that subcutaneous administration of PT320, a sustained-release (SR) form of exendin-4, resulted in the long-term maintenance of steady-state exenatide (exendin-4) plasma and target levels in 6-hydroxydopamine (6-O
Externí odkaz:
https://doaj.org/article/adce99f482d94f8da74c059822b34571