Zobrazeno 1 - 10
of 824
pro vyhledávání: '"BARD1"'
Autor:
Xin Yue, Tingyu Liu, Xuecen Wang, Weijian Wu, Gesi Wen, Yang Yi, Jiaxin Wu, Ziyang Wang, Weixiang Zhan, Ruirui Wu, Yuan Meng, Zhirui Cao, Liyuan Le, Wenyan Qiu, Xiaoyue Zhang, Zhenyu Li, Yong Chen, Guohui Wan, Xianzhang Bu, Zhenwei Peng, Ran-yi Liu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 8, Pp 3382-3399 (2023)
Radiotherapy is widely used in the management of advanced colorectal cancer (CRC). However, the clinical efficacy is limited by the safe irradiated dose. Sensitizing tumor cells to radiotherapy via interrupting DNA repair is a promising approach to c
Externí odkaz:
https://doaj.org/article/8ccb9288afe54949a3329ce24041a1b9
Autor:
Sergio Carrera, Ana Belén Rodríguez-Martínez, Intza Garin, Esther Sarasola, Cristina Martínez, Hiart Maortua, Almudena Callejo, Abigail Ruiz de Lobera, Alberto Muñoz, Nagore Miñambres, Pablo Jiménez-Labaig
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 21, Iss 1, Pp 1-7 (2023)
Abstract Background Colorectal cancer (CRC) is a highly prevalent disease in developed countries. Inherited Mendelian causes account for approximately 5% of CRC cases, with Lynch syndrome and familial adenomatous polyposis being the most prevalent fo
Externí odkaz:
https://doaj.org/article/8c8efdb9163544a7ab074ca0bd794325
Autor:
R. Graffeo, H.Q. Rana, F. Conforti, B. Bonanni, M.J. Cardoso, S. Paluch-Shimon, O. Pagani, A. Goldhirsch, A.H. Partridge, M. Lambertini, J.E. Garber
Publikováno v:
Breast, Vol 65, Iss , Pp 32-40 (2022)
Breast cancer risk associated with germline likely pathogenic/pathogenic variants (PV) varies by gene, often by penetrance (high >50% or moderate 20–50%), and specific locus.Germline PVs in BRCA1 and BRCA2 play important roles in the development of
Externí odkaz:
https://doaj.org/article/e44df9fcbd18407d8a8d66a00d033c2a
Autor:
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-23 (2022)
Abstract The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domai
Externí odkaz:
https://doaj.org/article/a6082ff45d8b4d468e7c52be8ebeb5dc
Autor:
Yuanting Zheng, Bingying Li, Dejing Pan, Jun Cao, Jian Zhang, Xiaolin Wang, Xiangnan Li, Wanwan Hou, Ding Bao, Luyao Ren, Jingcheng Yang, Shangzi Wang, Yangyang Qiu, Fei Zhou, Zhiwei Liu, Sibo Zhu, Lei Zhang, Tao Qing, Yi Wang, Ying Yu, Jiaxue Wu, Xichun Hu, Leming Shi
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-7 (2021)
Abstract We identified a rare missense germline mutation in BARD1 (c.403G>A or p.Asp135Asn) as pathogenic using integrated genomics and transcriptomics profiling of germline and tumor samples from an early-onset triple-negative breast cancer patient
Externí odkaz:
https://doaj.org/article/8de1ab0ab9da4a178e3bad78f29b737a
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 10, Iss 3, Pp n/a-n/a (2022)
Abstract Background BRCA1‐associated RING Domain 1 (BARD1) is an important gene related to breast cancer development. However, the role of BARD1 mutations in breast cancer remains inconclusive. This study is to investigate the relationship between
Externí odkaz:
https://doaj.org/article/fde68f80c22648b3aa5b31e33ebf21ed
Autor:
Nana Weber-Lassalle, Julika Borde, Konstantin Weber-Lassalle, Judit Horváth, Dieter Niederacher, Norbert Arnold, Silke Kaulfuß, Corinna Ernst, Victoria G. Paul, Ellen Honisch, Kristina Klaschik, Alexander E. Volk, Christian Kubisch, Steffen Rapp, Nadine Lichey, Janine Altmüller, Louisa Lepkes, Esther Pohl-Rescigno, Holger Thiele, Peter Nürnberg, Mirjam Larsen, Lisa Richters, Kerstin Rhiem, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Rita K. Schmutzler, Eric Hahnen, Jan Hauke
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-6 (2019)
Abstract Background The role of the BARD1 gene in breast cancer (BC) and ovarian cancer (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results. We aimed to assess the role of deleterious BARD
Externí odkaz:
https://doaj.org/article/6542c7dcf6614ef1973c45fb57592c84
Autor:
Stewart, Mikaela D., Zelin, Elena, Dhall, Abhinav, Walsh, Tom, Upadhyay, Esha, Corn, Jacob E., Chatterjee, Champak, King, Mary-Claire, Klevit, Rachel E.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Feb 01. 115(6), 1316-1321.
Externí odkaz:
https://www.jstor.org/stable/26507179
Autor:
Qianyan Li, JoAnne Engebrecht
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Meiosis is a specialized cell cycle that results in the production of haploid gametes for sexual reproduction. During meiosis, homologous chromosomes are connected by chiasmata, the physical manifestation of crossovers. Crossovers are formed by the r
Externí odkaz:
https://doaj.org/article/334496c173254b5da39a4adc7a2baf17
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