Integration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma

Autor: Moritz Bewarder, Maximilian Kiefer, Clara Moelle, Lisa Goerens, Stephan Stilgenbauer, Konstantinos Christofyllakis, Dominic Kaddu-Mulindwa, Natalie Fadle, Evi Regitz, Frank Neumann, Markus Hoth, Klaus-Dieter Preuss, Michael Pfreundschuh, Lorenz Thurner

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Recently, neurabin-I and SAMD14 have been described as the autoantigenic target of approximately 66% of B-cell receptors (BCRs) of primary central nervous system lymphomas (PCNSL). Neurabin-I and SAMD14 share a highly homologous SAM domain that becom

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Skewed Inactivation of X Chromosome: A Cause of Hemophilia Manifestation in Carrier Females.

Autor: Shoukat HMH; Internal Medicine, Premier Health/Wright State University, Dayton, USA., Ghous G; Internal Medicine, University of Missouri, Columbia, USA., Tarar ZI; Internal Medicine, University of Missouri, Columbia, USA., Shoukat MM; Pediatric Medicine, Children's Hospital, Lahore, PAK., Ajmal N; Pathology, King Edward Medical University, Mayo Hospital, Lahore, PAK.

Publikováno v: Cureus [Cureus] 2020 Oct 28; Vol. 12 (10), pp. e11216. Date of Electronic Publication: 2020 Oct 28.