Zobrazeno 1 - 10
of 67
pro vyhledávání: '"BAM15"'
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-11 (2024)
Abstract Background Toxoplasmosis is a zoonotic disease caused by the infection of the protozoa Toxoplasma gondii (T. gondii), and safe and effective therapeutic drugs are lacking. Mitochondria, is an important organelle that maintains T. gondii surv
Externí odkaz:
https://doaj.org/article/42d7440dee1b4c8694669f3a7478c46e
Akademický článek
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Autor:
Wagner S. Dantas, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Z. Elizabeth Floyd, Yongmei Yu, Hisashi Fujioka, Charles L. Hoppel, Kathryn P. Belmont, Christopher L. Axelrod, John P. Kirwan
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1821-1836 (2022)
Abstract Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle
Externí odkaz:
https://doaj.org/article/04ea9ee21dc2491bba4d381201f55dcb
Autor:
Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Wilasinee Saisorn, Chonnavee Manipuntee, Kittawat Plengplang, Samarch Sittichaitaweekul, Panisa Jenphatanapong, Suwasin Udomkarnjananun, Warerat Kaewduangduen, Kasirapat Ariya-anandech, Amanee Samaeng, Numpon Insin, Patcharee Ritprajak, Asada Leelahavanichkul
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2695 (2023)
Macrophage polarization requires different energy sources and metabolic processes. Therefore, cell energy interference to alter macrophage functions has been proposed as a treatment for severe inflammatory diseases, including sepsis. In this study, t
Externí odkaz:
https://doaj.org/article/5db89dab09c54659aa33a1729848f1d5
Autor:
Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore, John P. Kirwan
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We have previously identif
Externí odkaz:
https://doaj.org/article/73646908050a40a890022b3871277182
Autor:
Cong Phi Dang, Jiraphorn Issara-Amphorn, Awirut Charoensappakit, Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Wilasinee Saisorn, Kritsanawan Sae-Khow, Asada Leelahavanichkul
Publikováno v:
Journal of Innate Immunity, Pp 1-17 (2021)
Controlof immune responses through the immunometabolism interference is interesting for sepsis treatment. Then, expression of immunometabolism-associated genes and BAM15, a mitochondrial uncoupling agent, was explored in a proinflammatory model using
Externí odkaz:
https://doaj.org/article/079e87163391467fb833df3fd05cd430
Autor:
Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel, John P Kirwan
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-20 (2020)
Abstract Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long‐term weight control. This is due, in part, to difficulties in identifying tolerab
Externí odkaz:
https://doaj.org/article/61fe5cb6b2dd4631b169f643148abc19
Akademický článek
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Publikováno v:
Metabolites, Vol 12, Iss 11, p 1129 (2022)
BAM15 was recently screened as a protonophore uncoupler specifically for the mitochondrial membrane but not the plasma membrane. It is equally as potent as FCCP, but less toxic. Previously, mitochondrial uncoupling via DNP alleviates neurodegeneratio
Externí odkaz:
https://doaj.org/article/b2b9a400b15c435cb135f2cf84b6c028
Autor:
Garcia, Christopher James
Obesity and its comorbidities have emerged as serious healthcare concerns in the western world due to increased prevalence of nutritional overabundance and decreased physical activity. Due to the significant population affected and economic burden pl
Externí odkaz:
http://hdl.handle.net/10919/112254
