Zobrazeno 1 - 10
of 565
pro vyhledávání: '"BALARAMAN KALYANARAMAN"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Parkinson’s disease is managed using levodopa; however, as Parkinson’s disease progresses, patients require increased doses of levodopa, which can cause undesirable side effects. Additionally, the oral bioavailability of levodopa decreas
Externí odkaz:
https://doaj.org/article/1d7da3f1a53a4ec98651d9f0b50c54ca
Autor:
Anne P. M. Beerkens, Daan F. Boreel, James A. Nathan, Jiri Neuzil, Gang Cheng, Balaraman Kalyanaraman, Micael Hardy, Gosse J. Adema, Sandra Heskamp, Paul N. Span, Johan Bussink
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background Hypoxia is a common feature of many solid tumors and causes radiotherapy and immunotherapy resistance. Pharmacological inhibition of oxidative phosphorylation (OXPHOS) has emerged as a therapeutic strategy to reduce hypoxia. Howev
Externí odkaz:
https://doaj.org/article/6158a99077a34dd2a03b9ab6923fa43f
Autor:
Donghai Xiong, Zheng Yin, Mofei Huang, Yian Wang, Micael Hardy, Balaraman Kalyanaraman, Stephen T Wong, Ming You
Publikováno v:
Cancer Communications, Vol 44, Iss 3, Pp 448-452 (2024)
Externí odkaz:
https://doaj.org/article/905adf1e1a054b55a10eaca823da78b7
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103092- (2024)
In this review, we explore how short-chain fatty acids (SCFAs) produced by the gut microbiome affect Parkinson's disease (PD) through their modulatory interactions with alpha-synuclein, neuroinflammation, and oxidative stress mediated by reactive oxy
Externí odkaz:
https://doaj.org/article/4909cd4b508b466e911f051e341e5ee4
Autor:
Muhammet Ay, Adhithiya Charli, Monica Langley, Ahyoung Jang, Piyush Padhi, Huajun Jin, Vellareddy Anantharam, Balaraman Kalyanaraman, Arthi Kanthasamy, Anumantha G. Kanthasamy
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Impaired mitochondrial function and biogenesis have strongly been implicated in the pathogenesis of Parkinson’s disease (PD). Thus, identifying the key signaling mechanisms regulating mitochondrial biogenesis is crucial to developing new treatment
Externí odkaz:
https://doaj.org/article/9538d014a4cc40849dd2e9312bfc0253
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract N-acetylcysteine (NAC) has been used as an antioxidant drug in tumor cells and preclinical mice tumor xenografts, and it improves adaptive immunotherapy in melanoma. NAC is not readily bioavailable and is used in high concentrations. The eff
Externí odkaz:
https://doaj.org/article/36de649976e6430fb7bf5b8c796361cd
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Glycolytic and mitochondrial oxidative metabolism, which are two major energy sources in tumors, are potential targets in cancer treatment. Metabolic reprogramming from glycolysis to mitochondrial oxidative metabolism and vice versa is an ad
Externí odkaz:
https://doaj.org/article/83b882c85e184f7db509d6ca25a2f362
Autor:
Balaraman Kalyanaraman
Publikováno v:
Redox Biology, Vol 57, Iss , Pp 102497- (2022)
N-acetylcysteine (NAC) has been used as a direct scavenger of reactive oxygen species (hydrogen peroxide, in particular) and an antioxidant in cancer biology and immuno-oncology. NAC is the antioxidant drug most frequently employed in studies using t
Externí odkaz:
https://doaj.org/article/8b878f4c1d0246bbace0e1ec673fd64f
Autor:
Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Monika Rola, Angelika Artelska, Karolina Pierzchała, Jacek Zielonka, Balaraman Kalyanaraman, Adam Bartłomiej Sikora
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (•NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years,
Externí odkaz:
https://doaj.org/article/1977414ea6e4468c93c4a0979a7609c0
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Therapeutic targeting of tumor vulnerabilities is emerging as a key area of research. This review is focused on exploiting the vulnerabilities of tumor cells and the immune cells in the tumor immune microenvironment (TIME), including tumor hypoxia, t
Externí odkaz:
https://doaj.org/article/eccc140d9af74a55a47af50030177d39