Dynamic treatment effect phenotyping through functional survival analysis

Autor: Gregorio, Caterina, Baj, Giovanni, Barbati, Giulia, Ieva, Francesca

In recent years, research interest in personalised treatments has been growing. However, treatment effect heterogeneity and possibly time-varying treatment effects are still often overlooked in clinical studies. Statistical tools are needed for the i

Externí odkaz: http://arxiv.org/abs/2310.16690

Physical fitness and body build parameters of children and adolescents participating in the physical activity promotion programme 'Athletics for all!'

Autor: Joanna Baj-Korpak, Kamil Zaworski, Marek Wochna, Sebastian Chmara, Marian Jan Stelmach

Publikováno v: Archives of Public Health, Vol 82, Iss 1, Pp 1-14 (2024)

Abstract Background This study attempts to analyse physical fitness and basic anthropometric parameters of children and adolescents participating in the nationwide physical activity promotion programme “Athletics for All!” (AFA). The programme ai

Externí odkaz: https://doaj.org/article/88e68f51b6be45f199f35bbd5c343067

ExoClock Project III: 450 new exoplanet ephemerides from ground and space observations

Autor: Kokori, A., Tsiaras, A., Edwards, B., Jones, A., Pantelidou, G., Tinetti, G., Bewersdorff, L., Iliadou, A., Jongen, Y., Lekkas, G., Nastasi, A., Poultourtzidis, E., Sidiropoulos, C., Walter, F., Wünsche, A., Abraham, R., Agnihotri, V. K., Albanesi, R., Arce-Mansego, E., Arnot, D., Audejean, M., Aumasson, C., Bachschmidt, M., Baj, G., Barroy, P. R., Belinski, A. A., Bennett, D., Benni, P., Bernacki, K., Betti, L., Biagini, A., Bosch, P., Brandebourg, P., Brát, L., Bretton, M., Brincat, S. M., Brouillard, S., Bruzas, A., Bruzzone, A., Buckland, R. A., Caló, M., Campos, F., Carreno, A., Rodrigo, J. -A. Carrion, Casali, R., Casalnuovo, G., Cataneo, M., Chang, C. -M., Changeat, L., Chowdhury, V., Ciantini, R., Cilluffo, M., Coliac, J. -F., Conzo, G., Correa, M., Coulon, G., Crouzet, N., Crow, M. V., Curtis, I., Daniel, D., Dawes, S., Dauchet, B., Deldem, M., Deligeorgopoulos, D., Dransfield, G., Dymock, R., Eenmäe, T., Evans, P., Esseiva, N., Falco, C., Farfán, R. G., Fernández-Lajús, E., Ferratfiat, S., Ferreira, S. L., Ferretti, A., Fiołka, J., Fowler, M., Futcher, S. R., Gabellini, D., Gainey, T., Gaitan, J., Gajdoš, P., García-Sánchez, A., Garlitz, J., Gillier, C., Gison, C., Horta, F. Grau, Grivas, G., Gonzales, J., Gorshanov, D., Guerra, P., Guillot, T., Haswell, C. A., Haymes, T., Hentunen, V. -P., Hills, K., Hose, K., Humbert, T., Hurter, F., Hynek, T., Irzyk, M., Jacobsen, J., Jannetta, A. L., Johnson, K., Jóźwik-Wabik, P., Kaeouach, A. E., Kang, W., Kiiskinen, H., Kim, T., Kivila, Ü., Koch, B., Kolb, U., Kučáková, H., Lai, S. -P., Laloum, D., Lasota, S., Lewis, L. A., Liakos, G. -I., Libotte, F., Lopresti, C., Lomoz, F., Majewski, R., Malcher, A., Mallonn, M., Mannucci, M., Marchini, A., Mari, J. -M., Marino, A., Marino, G., Mario, J. -C., Marquette, J. -B., Martínez-Bravo, F. A., Mašek, M., Matassa, P., Michel, P., Michelet, J., Miller, M., Miny, E., Mollier, T., Molina, D., Monteleone, B., Montigiani, N., Morales-Aimar, M., Mortari, F., Morvan, M., Mugnai, L. V., Murawski, G., Naponiello, L., Naves, R., Naudin, J. -L., Néel, D., Neito, R., Neveu, S., Noschese, A., Öğmen, Y., Ohshima, O., Orbanic, Z., Pace, E. P., Pantacchini, C., Paschalis, N. I., Pereira, C., Peretto, I., Perroud, V., Phillips, M., Pintr, P., Pioppa, J. -B., Plazas, J., Poelarends, A. J., Popowicz, A., Purcell, J., Quinn, N., Raetz, M., Rees, D., Regembal, F., Rocchetto, M., Rocci, P. -F., Rockenbauer, M., Roth, R., Rousselot, L., Rubia, X., Ruocco, N., Russo, E., Salisbury, M., Salvaggio, F., Santos, A., Savage, J., Scaggiante, F., Sedita, D., Shadick, S., Silva, A. F., Sioulas, N., Školník, V., Smith, M., Smolka, M., Solmaz, A., Stanbury, N., Stouraitis, D., Tan, T. -G., Theusner, M., Thurston, G., Tifner, F. -P., Tomacelli, A., Tomatis, A., Trnka, J., Tylšar, M., Valeau, P., Vignes, J. -P., Villa, A., Sureda, A. Vives, Vora, K., Vrašťák, M., Walliang, D., Wenzel, B., Wright, D. E., Zambelli, R., Zhang, M., Zíbar, M.

The ExoClock project has been created with the aim of increasing the efficiency of the Ariel mission. It will achieve this by continuously monitoring and updating the ephemerides of Ariel candidates over an extended period, in order to produce a cons

Externí odkaz: http://arxiv.org/abs/2209.09673

Preclinical alternative drug discovery programs for monogenic rare diseases. Should small molecules or gene therapy be used? The case of hereditary spastic paraplegias

Autor: Caron, Giulia, Lamacchia, Lorenzo, Francisco, Serena, Brusco, Alfredo, Pullano, Verdiana, Baj, Gabriele, Gurgone, Antonia, Chiantia, Giuseppe, Giustetto, Maurizio, Russo, Silvia, Higgins, Anna J., van Putte, Wouter, Vecchia, Stefania Della, Battini, Roberta, Maria Santorelli, Filippo, Sebastiano, Matteo Rossi, Hadano, Shinji, Cesca, Fabrizia, Ermondi, Giuseppe

Publikováno v: In Drug Discovery Today October 2024 29(10)

ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota

Autor: Tanja Eberhart, Federico Uchenna Stanley, Luisa Ricci, Tiziana Chirico, Roberto Ferrarese, Sofia Sisti, Alessandra Scagliola, Andreina Baj, Sylvia Badurek, Andreas Sommer, Rachel Culp-Hill, Monika Dzieciatkowska, Engy Shokry, David Sumpton, Angelo D’Alessandro, Nicola Clementi, Nicasio Mancini, Simone Cardaci

Publikováno v: Cell Death and Disease, Vol 15, Iss 2, Pp 1-16 (2024)

Abstract Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe surviv

Externí odkaz: https://doaj.org/article/3cd0e9d0544a4871a65621196c1cf98d