Výsledky vyhledávání - "B.R. Morehouse"

STING cyclic dinucleotide sensing originated in bacteria

Autor: Apurva A. Govande, Sichen Shao, Rotem Sorek, Alexander F.A. Keszei, Gal Ofir, Adi Millman, B.R. Morehouse, Philip J. Kranzusch, B. Lowey

Publikováno v: Nature

Stimulator of interferon genes (STING) is a receptor in human cells that senses foreign cyclic dinucleotides that are released during bacterial infection and in endogenous cyclic GMP-AMP signalling during viral infection and anti-tumour immunity1-5.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890a005c85eec007fce74149cee4e62
http://europepmc.org/articles/PMC7572726

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cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

Autor: Jean-Luc Imler, Martin König, Ziming Wei, Adelyn E. Ragucci, Roland Seifert, Heike Bähre, Amy S. Lee, Philip J. Kranzusch, Xianlong Ai, Yuqiang Chen, Hua Cai, Wen Zhou, Lihua Li, B.R. Morehouse, Kailey Slavik

Publikováno v: Nature
Nature, Nature Publishing Group, 2021, 597 (7874), pp.109-113. ⟨10.1038/s41586-021-03743-5⟩
Nature, 2021, 597 (7874), pp.109-113. ⟨10.1038/s41586-021-03743-5⟩

Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor that produces the second messenger cG[2′–5′]pA[3′–5′]p (2′3′-cGAMP) and controls activation of innate immunity in mammalian cells1–5. Animal genomes typically encode multipl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97efd782ea75c8d4736e43e6ea12ae33
https://hal.archives-ouvertes.fr/hal-03340059/document

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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

Autor: Aaron T. Whiteley, E.A. Nieminen, James B. Eaglesham, B. Lowey, John J. Mekalanos, Olga Danilchanka, Philip J. Kranzusch, B.R. Morehouse, David S. King, C.C. de Oliveira Mann, Amy S. Lee

Publikováno v: Nature

Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28215a1a1ff4a4cddb10d5e9a7a2b91
http://europepmc.org/articles/PMC6544370

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CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

Autor: Sadie P. Antine, Amy S. Lee, Ian T. Mathews, B. Lowey, Mohit Jain, Victor J. Cabrera, John J. Mekalanos, Alexander F.A. Keszei, Frank Schwede, Aaron T. Whiteley, Sichen Shao, B.R. Morehouse, Percy Niemann, Dmitry Kashin, Philip J. Kranzusch

Publikováno v: Cell. 182(1)

cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes are immune sensors that synthesize nucleotide second messengers and initiate antiviral responses in bacterial and animal cells. Here, we discover Enterobacter cloacae CD-NTase-associated protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8ab97e1d92ad665006d37beb0a54fa
https://pubmed.ncbi.nlm.nih.gov/32649879

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Cyclic pyrimidines defend against phages

Autor: Alexander F.A. Keszei, Carmel Avraham, Tevie Mehlman, B.R. Morehouse, Avigail Stokar-Avihail, Sichen Shao, Taya Fedorenko, Erez Yirmiya, Adi Millman, Rotem Sorek, Yaara Oppenheimer-Shaanan, Philip J. Kranzusch, Gil Amitai, Nitzan Tal, Alexander Brandis, Ehud Herbst

Publikováno v: Cell

The cyclic pyrimidines 3',5'-cyclic cytidine monophosphate (cCMP) and 3',5'-cyclic uridine monophosphate (cUMP) have been reported in multiple organisms and cell types. As opposed to the cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978c7331714ea37ca279c08e98502157
https://doi.org/10.1038/s41579-021-00658-w

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Structural Characterization of Early Michaelis Complexes in the Reaction Catalyzed by (+)-Limonene Synthase from Citrus sinensis Using Fluorinated Substrate Analogues

Autor: Hongkun Lin, Karan Malik, Ramasamy P. Kumar, B.R. Morehouse, Isaac J. Krauss, Jason O. Matos, Daniel D. Oprian

Publikováno v: Biochemistry. 56:1716-1725

The stereochemical course of monoterpene synthase reactions is thought to be determined early in the reaction sequence by selective binding of distinct conformations of the geranyl diphosphate (GPP) substrate. We explore here formation of early Micha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae827047dd06c879a1ff96e12b11133e
https://doi.org/10.1021/acs.biochem.7b00144

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Direct evidence for an enzyme generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog

Autor: B.R. Morehouse, Q Yu, Ramasamy P. Kumar, A Bannister, J.S Temme, Daniel D. Oprian, K Malik, Isaac J. Krauss, Jason O. Matos

Publikováno v: ACS Chem Biol

Linalyl diphosphate (LPP) is the postulated intermediate in the enzymatic cyclization of monoterpenes catalyzed by terpene synthases. LPP is considered an obligate intermediate due to the conformationally restrictive trans-C2-C3 double bond of the su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c50f25050608317ecce2fb06dfd5f40
https://europepmc.org/articles/PMC7843008/

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Structure and monomer/dimer equilibrium for the guanylyl cyclase domain of the optogenetics protein RhoGC

Autor: Daniel H. Zhou, Molly O. Lorenz, Josiane Fofana, Daniel D. Oprian, B.R. Morehouse, Melissa M. Trieu, Ramasamy P. Kumar

RhoGC is a fusion protein from the aquatic fungus Blastocladiella emersonii, combining a type I rhodopsin domain with a guanylyl cyclase domain. It has generated excitement as an optogenetics tool for the manipulation of cyclic nucleotide signaling p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf6653f252db25cdd2c9b61c2e551ab
https://europepmc.org/articles/PMC5766957/

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Functional and Structural Characterization of a (+)-Limonene Synthase from Citrus sinensis

Autor: Sarah Naomi Olsen, Ramasamy P. Kumar, Sonya Entova, Jason O. Matos, B.R. Morehouse, Daniel D. Oprian

Publikováno v: Biochemistry. 56(12)

Terpenes make up the largest and most diverse class of natural compounds and have important commercial and medical applications. Limonene is a cyclic monoterpene (C10) present in nature as two enantiomers, (+) and (-), which are produced by different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffba08b7e1b3f6d018462ce08a54d83
https://pubmed.ncbi.nlm.nih.gov/28272875

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