HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

Autor: Stephen P. Peters, David T. Mauger, E. Israel, W. G. Teague, Peter Bazeley, Bruce D. Levy, Sally E. Wenzel, Mohammad Alyamani, Jr Igo Rp, Nima Sharifi, Nizar N. Jarjour, B.M. Gaston, K.F. Chung, Deborah A. Meyers, Ortega, Nadzeya Marozkina, Serpil C. Erzurum, Mario Castro, G.A. Hawkins, Wendy C. Moore, Calvin Cotton, Eugene R. Bleecker, John V. Fahy, DeBoer, William J. Calhoun, Anne M. Fitzpatrick, William W. Busse, Xu W, Manesh R. Patel, Patricia Noel, Joe Zein, Suzy A. A. Comhair

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 4
Proceedings of the National Academy of Sciences of the United States of America

Significance Although resistance to glucocorticoids is a major clinical problem, the underlying mechanisms are unknown. It is known that glucocorticoid use can suppress adrenal androgen production. In population studies, animal models, and cell cultu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30163713b2aea945a7cce53304d8a430
https://doi.org/10.1073/pnas.1918819117

A Safe Inhaled Alkaline Treatment That Inhibits Respiratory Viral Infections

Autor: Jessica L Saunders, R. F. Relich, B.M. Gaston, Lewis J. Smith, M. D. Davis

Publikováno v: TP94. TP094 DISCOVERIES IN BACTERIAL AND VIRAL PNEUMONIA PATHOGENESIS.

Introduction: Viral respiratory infection causes significant mortality and morbidity, particularly in patients with chronic airways diseases such as cystic fibrosis. In order to enter host cells and replicate, most respiratory viruses require an acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f319a2c8b035ff496d51785a25d7caf
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a3905

Deep Resequencing of the Beta-2 Adrenergic Receptor Gene (ADRB2) in COPD and Asthma Cohorts Identifies Functional Rare Variants

Autor: E. Israel, G.A. Hawkins, Wendy C. Moore, Igor Barjaktarevic, Nadia N. Hansel, Eric A. Hoffman, Victor E. Ortega, D. Couper, Bruce D. Levy, Joe Zein, Robert Paine, Fernando J. Martinez, R.P. Bowler, MeiLan K. Han, Stephen P. Peters, Stephen B. Liggett, Annette T. Hastie, Eugene R. Bleecker, Deborah A. Meyers, Nizar N. Jarjour, Serpil C. Erzurum, Nhlbi Sarp, Loren C. Denlinger, Mario Castro, Xingnan Li, Anne M. Fitzpatrick, P.G. Woodruff, Richard E. Kanner, John V. Fahy, Nhlbi Spiromics, Wanda K. O'Neal, Dave Mauger, Sally E. Wenzel, E. Ampleford, B.M. Gaston, R.G. Barr, D. Kim, Christopher B. Cooper

Publikováno v: B94. ADULT AND PEDIATRIC ASTHMA GENETIC STUDIES.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee697591ffa8e5f23c3983b51586dddf
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4220

The PH and NO of the Normal Human Subcarinal Airway: Bronchoscopic Techniques for Measuring Human Airway Chemistry

Autor: F. Cui, Kristie R. Ross, Nadzeya Marozkina, J. Reynolds, Michael D Davis, Laura Smith, B.M. Gaston, O.K. Giddings

Publikováno v: A67. STRUCTURE-FUNCTION RELATIONSHIPS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d92ce2f64ce83300c3adad28e951d27
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2355

Age Dependent Differences in Seasonal Versus Perennial Allergen Sensitivity in Association with Severe Asthma

Autor: R. Wojcik, M.L. Fajt, J.V. Fahy, E.R. Bleecker, D.A. Meyers, N.N. Jarjour, M. Castro, E. Israel, B.D. Levy, W. Phipatanakul, A.M. Fitzpatrick, S.C. Erzurum, B.M. Gaston, S.E. Wenzel, W.C. Moore, A.T. Hastie, null Severe Asthma Research Program III

Publikováno v: B102. DISPARITIES IN ASTHMA MANAGEMENT.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58f83e99ab48854850aba4dbb2b8eede
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4076