Výsledky vyhledávání - "B.K. Sharath"

Malabarase, a serine protease with anticoagulant activity from Trimeresurus malabaricus venom

Autor: K. K. Dharmappa, Raju Venkatesh Kumar, B.K. Sharath, M. Yariswamy, Vikram Joshi, Shivaprasad H. Venkatesha, Bannikuppe S. Vishwanath

Publikováno v: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 164:111-116

In the present study we describe the purification and characterization of Malabarase, a serine protease from Trimeresurus malabaricus venom. Purification was achieved by gel-permeation chromatography on Sephadex G-75 followed by ion-exchange chromato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c01945e8f98eda080160f0c9ad9f7f7
https://doi.org/10.1016/j.cbpb.2012.11.004

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Characterization of Major Zinc Containing Myonecrotic and Procoagulant Metalloprotease ‘Malabarin’ from Non Lethal Trimeresurus malabaricus Snake Venom with Thrombin Like Activity: Its Neutralization by Chelating Agents

Autor: B.K. Sharath, Holenarasipura V. Shivaprasad, Bannikuppe S. Vishwanath, R. Rajesh, C.D. Raghavendra Gowda, Y. K. Saikumari, Brigitte M. Frey, R. Venkatesh Kumar, Felix J. Frey

Publikováno v: Current Topics in Medicinal Chemistry. 11:2578-2588

A major myonecrotic zinc containing metalloprotease `malabarin' with thrombin like activity was purified by the combination of gel permeation and anion exchange chromatography from T. malabaricus snake venom. MALDI-TOF analysis of malabarin indicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4762cec073183e6c7b196226b5d7090c
https://doi.org/10.2174/156802611797633375

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Vanillic acid as a novel specific inhibitor of snake venom 5′-nucleotidase: A pharmacological tool in evaluating the role of the enzyme in snake envenomation

Autor: B.K. Sharath, B. L. Dhananjaya, A. Nataraju, C.D. Raghavendra Gowda, Cletus J. M. D'Souza

Publikováno v: Biochemistry (Moscow). 74:1315-1319

Vanillic acid has been investigated for its inhibitory effect on Naja naja, Daboia russellii, and Trimeresurus malabaricus venom 5'-nucleotidase activity. Trimeresurus malabaricus venom 5'-nucleotidase activity was 1.3- and 8.0-fold higher than that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b415525086354bb9dfc3d98df0aa522
https://doi.org/10.1134/s0006297909120037

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Strong myotoxic activity of Trimeresurus malabaricus venom: Role of metalloproteases

Autor: T. V. Gowda, A. Nataraju, A. R. Raghupathi, B. L. Dhananjaya, B.K. Sharath, Bannikuppe S. Vishwanath, C.D. Raghavendra Gowda, R. Rajesh

Publikováno v: Molecular and Cellular Biochemistry. 282:147-155

Trimeresurus malabaricus is an endemic snake found in the Southern region of Western Ghats section of India along with the more widely distributed species like Naja naja and Daboia russelii. T. malabaricus venom is not lethal when injected (i.p.) up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09976de869a5b7fe1d96aec43223af31
https://doi.org/10.1007/s11010-006-1738-3

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Purification and characterization of 'Trimarin' a hemorrhagic metalloprotease with factor Xa-like Activity, from Trimeresurus malabaricus snake venom

Autor: R. Venkatesh Kumar, Bannikuppe S. Vishwanath, C.D. Raghavendra Gowda, B.K. Sharath, Holenarasipura V. Shivaprasad, Jalahalli M. Siddesha

Publikováno v: Thrombosis research. 126(5)

In the present study, we describe the purification and characterization of a metalloprotease ‘trimarin’ from Trimeresurus malabaricus snake venom. Trimarin is a single-chain basic protein, with a molecular mass of 29.6 kDa. Trimarin showed proteo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea8b3fc82acc28bccb7e9c29d999de9
https://pubmed.ncbi.nlm.nih.gov/20850171

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Anticoagulant effect of Naja naja venom 5'nucleotidase: demonstration through the use of novel specific inhibitor, vanillic acid

Autor: R. Rajesh, B.K. Sharath, Cletus J. M. D'Souza, B. L. Dhananjaya, Bannikuppe S. Vishwanath, C.D. Raghavendra Gowda, A. Nataraju

Publikováno v: Toxicon : official journal of the International Society on Toxinology. 48(4)

The snake venom proteins affect hemostasis by either advancing/delaying blood coagulation. Apart from proteases and phospholipase A(2)s (PLA(2)s), 5'nucleotidase is known to affect hemostasis by inhibiting platelet aggregation. In this study, the pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0639bc77e8113c0874c5b5530f46a787
https://pubmed.ncbi.nlm.nih.gov/16899266

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Differential action of proteases from Trimeresurus malabaricus, Naja naja and Daboia russellii venoms on hemostasis

Autor: A. Nataraju, B.K. Sharath, B.L. Dhananjaya, Bannikuppe S. Vishwanath, R. Rajesh, C.D. Raghavendra Gowda

Publikováno v: Comparative biochemistry and physiology. Toxicologypharmacology : CBP. 143(3)

The action of venom proteases and their role in hemostasis has been compared in the venoms of Trimeresurus malabaricus, Daboia russellii and Naja naja from the Southern region of Western Ghats, India. These venoms exhibit varying amounts of proteolyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639cd2af60876842e430017a3337157b
https://pubmed.ncbi.nlm.nih.gov/16627005

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