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pro vyhledávání: '"B.F. Michael"'
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Autor:
Dan A. Ostlind, Marlene D. Drag, Matthew J. Wyvratt, Pierre deMontigny, David W. Fink, Steven L. Colletti, Wesley L. Shoop, Michelle B. Ayer, Chunshi Li, Steve Salva, Michelle Zakson, Lynn M. Warmke, Peter T. Meinke, Thomas L. Shih, Dong Ok, Michael H. Fisher, B.F. Michael, Dennis M. Schmatz, Julie Lim
Publikováno v:
Journal of Medicinal Chemistry. 52:3505-3515
Nodulisporic acid A (1) is a structurally complex fungal metabolite that exhibits systemic efficacy against fleas via modulation of an invertebrate specific glutamate-gated ion channel. In order to identify a nodulisporamide suitable for monthly oral
Autor:
B.F. Michael, Francisca Vicente, Thomas J. Felcetto, Sang Ho Lee, Mary Motyl, John J. Allocco, Sookhee Ha, Karen Dorso, Lorraine D. Hernandez, José R. Tormo, Chaowei Zhang, Andrew Galgoci, Katherine Young, Dennis M. Schmatz, Jun Wang, Wesley L. Shoop, Fernando Pelaez, Olga Genilloud, John G. Ondeyka, Lawrence F. Colwell, Ken Bartizal, Sheo B. Singh, Ronald E. Painter, Angela Basilio, Richard D. Cummings, Charles Gill, Stephen M. Soisson, Hiranthi Jayasuriya, Lynn L. Silver, John F. Barrett, Srinivas Kodali, Kithsiri Herath, Gopalakrishnan Parthasarathy, Yui S. Tang, Joseph W. Becker, Doris F. Cully, Jeffery D. Hermes
Publikováno v:
Nature. 441:358-361
The worldwide spread of antibiotic resistance in pathogenic bacteria raises serious concerns that today's front-line antibiotics may become ineffective. So the discovery of a new class of compound with enormous potential as antibiotics is of great in
Autor:
Christine McCallum, Ester Carballo-Jane, Suzy Kwon, Gail Forrest, Chris M. Thompson, Anne Gurnett, Wesley L. Shoop, T. Felcetto, B.F. Michael, Betsy Frantz-Wattley, Edward A. O'Neill, Penny Sue Leavitt, Dennis M. Zaller
Publikováno v:
Therapy. 2:261-273
Background: The mode of action of triptolide, the active ingredient of an anti-inflammatory Chinese herbal remedy, has been investigated in vitro and in vivo. Prior reports suggested that triptolide specifically inhibits the nuclear transcription fac
Publikováno v:
Journal of the Association for Laboratory Automation. 5:79-84
here has been relatively little progress in the area of highthroughput screening for antiparasitic animal health tar-gets, which involve whole organisms such as Haemonchus contortus and Caenorhabditis elegans. Mostassays involve identifying compounds
Autor:
Lyndia Slayton, L.M. Gregory, William C. Campbell, M.J. Turner, B.J. Skelly, M. H. Fisher, J. R. Egerton, Dan A. Ostlind, H.W. Haines, B.F. Michael, R.K. Fulton, Helmut Mrozik, D. Barth, C.H. Eary, P. Eskola, R. L. Seward, S.D. Costa, Wesley L. Shoop
Publikováno v:
International Journal for Parasitology. 26:1237-1242
Eprinomectin (MK-397 or 4"-epi-acetylamino-4"-deoxy-avermectin B1) is a novel avermectin selected for development as a topical endectocide for all cattle, including lactating dairy cows. Herein, we show its anthelmintic, insecticidal and miticidal ac
Publikováno v:
Veterinary Parasitology. 53:153-157
Comb-counting and thumb-counting were compared in a cross-over study to determine which was more accurate for quantifying flea infestation levels on dogs. Twenty beagle dogs were used in the study and infested with either 50 or 100 adult fleas (Cteno
Autor:
Peter T. Meinke, B.F. Michael, Helmut Mrozik, Wesley L. Shoop, Gerard R. Dawson, Michael H. Fisher, Timothy A. Blizzard
Publikováno v:
ChemInform. 30
A series of gem-difluoro-avermectin derivatives was synthesized from the corresponding ketones at positions 4", 4', 13, and 23 using diethylaminosulfur trifluoride (DAST). These fluorinated avermectins exhibit potent antiparasitic activity in a new H
Publikováno v:
Veterinary Parasitology. 43:259-263
Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the adult stages of nine common gastrointestinal and lung nematodes of calves at single, oral dosages of 0.5, 1.0, 2.0 or 4.0 mg
Autor:
Richard Tschirret-Guth, Byron H. Arison, Maria Victoria Silva Elipe, B.F. Michael, Donald Thompson, Terry Faidley, Herve A. Aloysius, Timothy A. Blizzard, Wesley L. Shoop
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(8)
The disposition and metabolism of paraherquamide (PHQ), a potent and broad-spectrum anthelminthic, were examined in sheep, dogs, and gerbils. The metabolism of PHQ in these species was extensive and marked by significant species differences both in v