Zobrazeno 1 - 10
of 846
pro vyhledávání: '"B.D. Kahan"'
Autor:
B.D. Kahan, J. Pliszczynski
Publikováno v:
Transplantation Proceedings. 43:3657-3668
Objective Retrospective analysis of 10-year outcomes of sirolimus (SRL) plus varying exposure to cyclosporine (CsA) in combination therapy for renal transplantation. Methods Univariate, multivariate, and receiver operating characteristic (ROC) analys
Autor:
B.D. Kahan
Publikováno v:
Transplantation Proceedings. 43:2853-2859
The past 5 decades have documented remarkable advances in basic knowledge and clinical expertise in transplantation. The first 12 years of this half century of my participation in the enterprise were consumed with the isolation, chemical characteriza
Autor:
B.D. Kahan
Publikováno v:
Transplantation Proceedings. 43:822-825
Because of the pleiotropic toxicities of available immunosuppressants, new approaches have employed agents that seek to mitigate nephrotoxicity. Phase III trials of belatacept, a conjugate of cytotoxic lymphocyte antigen-4 (CTLA-4) and immunoglobulin
Autor:
B.D. Kahan
Publikováno v:
Transplantation Proceedings. 41:5-10
The fortieth—ruby—anniversary of publication of Transplantation Proceedings chronicles the major developments in this field of expanding scientific and clinical importance. The first decade of publication included seminal findings in immunogeneti
Autor:
H. Podder, B.D. Kahan
Publikováno v:
Transplantation Proceedings. 37:3723-3726
Introduction African-American renal transplant recipients are prone to acute rejection episodes and graft loss owing to genetic, pharmacokinetic, cultural, and socioeconomic factors. While more intense exposures to antirejection agents can mitigate t
Autor:
B.D Kahan
Publikováno v:
Transplantation Proceedings. 36:71-75
Sirolimus, a macrocyclic lactone that displays a novel mechanism of immunosuppressive action, is a critical-dose drug requiring therapeutic drug monitoring for optimal outcomes. This immunosuppressive agent was studied in two multicenter, blinded cli
Autor:
B.D Kahan, Stephen M. Katz, Hemangshu Podder, Charles T. Van Buren, Ronald H. Kerman, Richard J. Knight, Scott Zela
Publikováno v:
Transplantation. 75:1301-1306
BACKGROUND We investigated a novel immunosuppressive protocol including thymoglobulin induction in combination with sirolimus and corticosteroids, followed by introduction of markedly reduced exposures to cyclosporine to prevent pancreas-transplant r
Autor:
B.D Kahan, R.M Langer
Publikováno v:
Transplantation Proceedings. 34:1061-1066
Autor:
Johnny C. Hong, B.D Kahan
Publikováno v:
Transplantation. 71:1320-1328
Background.Avoidance of calcineurin antagonists for a prolonged period de novo after cadaver donor renal transplantation may facilitate recovery from delayed graft function. The present study examined the benefit of prolonging the calcineurin antagon
Autor:
B.D Kahan, Johnny C. Hong
Publikováno v:
Transplantation. 69:2085-2090
Background. Our study assessed the factors that predispose renal transplant recipients to the occurrence of thrombocytopenia and leukopenia, as well as the severity and the time- and concentration-dependence of these side-effects, after administratio