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Akademický článek
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Autor:
Samuel W. French, Brittany Tillman, O. Sweeny, B.A. French, Sara Samadzadeh, Maryam Masouminia, Nikoo F. Afifiyan
Several research strategies have been used to study the pathogenesis of alcoholic hepatitis (AH). These strategies have shown that various signaling pathways are the target of alcohol in liver cells. However, few have provided specific mechanisms ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aea2eb0d31bcf4d6f08219913b8768
https://europepmc.org/articles/PMC5680109/
https://europepmc.org/articles/PMC5680109/
Autor:
Brittany Tillman, Samuel W. French, Nikoo F. Afifiyan, B.A. French, E. Vitocruz, Alejandro Mendoza
Publikováno v:
Experimental and molecular pathology. 103(2)
Background and aim IL-8 (C-X-L motif chemokine ligase 8) and CXCR2 (C-X-C-motif chemokine receptor 2) are up regulated in alcoholic hepatitis (AH) liver biopsies. One of the consequences is the attraction and chemotactic neutrophilic infiltrate seen
Publikováno v:
Experimental and Molecular Pathology. 95:117-120
Previous studies on both human and mice livers showed MDB formation in both drug hepatitis and hepatocellular carcinoma. Using the drug hepatitis mouse model of MDB formation, numerous markers for progenitor cells were found in the cells forming MDBs
Autor:
Joan Oliva, B.A. French, Samuel W. French, Fawzia Bardag-Gorce, Brittany Tillman, A. Canaan, Jun Li
Publikováno v:
Experimental and Molecular Pathology. 93:309-314
Mallory–Denk bodies (MDBs) are aggresomes composed of undigested ubiqutinated short lived proteins which have accumulated because of a decrease in the rate of their degradation by the 26s proteasome. The decrease in the activity of the proteasome i
Autor:
Alejandro Mendoza, Brittany Tillman, Samuel W. French, Maryam Masouminia, B.A. French, Sara Samadzadeh
Publikováno v:
Experimental and molecular pathology. 101(1)
There are many homeostatic mechanisms for coping with stress conditions in cells, including autophagy. In many studies autophagy, as an intracellular pathway which degrades misfolded and damaged protein, and Mallory-Denk Body (MDB) formation have bee
Autor:
E. Vitocruz, Brittany Tillman, Guanghong Liao, B.A. French, Jun Li, Alejandro Mendoza, Hui Liu, Samuel W. French
Publikováno v:
Experimental and molecular pathology. 100(3)