Zobrazeno 1 - 10
of 479
pro vyhledávání: '"B. van Deurs"'
Autor:
Kirsten Sandvig, B. van Deurs
Publikováno v:
Gene Therapy. 12:865-872
A number of protein toxins of bacterial and plant origin have cytosolic targets, and knowledge about these toxins have provided us with essential information about mechanisms that can be used to gain access to the cytosol as well as detailed knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a394a9e0096d527dfc6bd869399938f4
https://doi.org/10.1038/sj.gt.3302525
https://doi.org/10.1038/sj.gt.3302525
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5175-5180
To investigate the role of clathrin in coated vesicle formation, a cell line with inducible expression of clathrin heavy chain (CHC) antisense RNA was produced. After 18 h of CHC antisense RNA expression, the internalization of transferrin was inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916826faede9d48e6155f11f31e7b301
https://doi.org/10.1073/pnas.0534231100
https://doi.org/10.1073/pnas.0534231100
Autor:
B. van Deurs, K. Sandvig
Publikováno v:
The EMBO Journal. 19:5943-5950
A large number of plant and bacterial toxins with enzymatic activity on intracellular targets are now known. These toxins enter cells by first binding to cell surface receptors, then they are endocytosed and finally they become translocated into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0c000c3cc93312a49e275c7ed087e
https://doi.org/10.1093/emboj/19.22.5943
https://doi.org/10.1093/emboj/19.22.5943
Autor:
B. van Deurs, Stine Grimmer, K. Rodal, Maria Lyngaas Torgersen, Tore Geir Iversen, Paolo Nicoziani, Kirsten Sandvig
Publikováno v:
ResearcherID
The plant toxin ricin binds to both glycoproteins and glycolipids with terminal galactose, and the toxin will therefore be endocytosed by the different mechanisms operating in a given cell. After endocytosis the toxin is transported to the Golgi appa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d4afa94ef54aedc51e8ddce4413dc2
https://doi.org/10.1016/s1438-4221(00)80055-7
https://doi.org/10.1016/s1438-4221(00)80055-7
Publikováno v:
ResearcherID
We have here used diphtheria toxin as a tool to investigate the type of endocytosis used by a glycosylphosphatidylinositol-linked molecule, a glycosylphosphatidylinositol-linked version of the diphtheria toxin receptor that is able to mediate intoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d29182bc1f162bd84133d3a3a18ff56
https://doi.org/10.1242/jcs.112.22.3899
https://doi.org/10.1242/jcs.112.22.3899
Autor:
K. Sandvig, B. van Deurs
Publikováno v:
Physiological Reviews. 76:949-966
Protein toxins such as ricin and Shiga toxin with intracellular targets have to be endocytosed and translocated to the cytosol to inhibit the protein synthesis and thereby kill the cell. Ricin is internalized by both clathrin-dependent and -independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf3982d0e30d8f77560f214203d5702
https://doi.org/10.1152/physrev.1996.76.4.949
https://doi.org/10.1152/physrev.1996.76.4.949
Publikováno v:
Europe PubMed Central
Electron microscopy of thick (0.2-1.0 micron) sections of cytochalasin D-treated cells fixed in the presence of Ruthenium red revealed an extensive, surface-connected tubular compartment in HEp-2 cells. The tubules measured 120–220 nm in diameter a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96600cef17b69ae6b347b1476095faf
https://doi.org/10.1242/jcs.109.7.1655
https://doi.org/10.1242/jcs.109.7.1655
Autor:
E M Danielsen, B. van Deurs
Publikováno v:
The Journal of Cell Biology
A GPI-anchored 80-kD protein was found to be the major component of detergent-insoluble complexes, prepared from fetal porcine small intestine, constituting about 25% of the total amount of protein. An antibody was raised to the 80-kD protein, and by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86092a23d5b0d023effe4c711138fb57
https://doi.org/10.1083/jcb.131.4.939
https://doi.org/10.1083/jcb.131.4.939
Autor:
M Jenstad, Knut Liestøl, Tove Irene Klokk, Bjørn Erikstein, Kirsten Sandvig, L Tcatchoff, Björn Risberg, Sascha Pust, N Musa, B. van Deurs, Håvard E. Danielsen
Publikováno v:
Oncogene. 32(29)
Amplification and overexpression of the receptor tyrosine kinase ErbB2 occur in up to 30% of human breast cancers, and high ErbB2 levels are correlated with poor prognosis for breast cancer patients. In contrast to the epithelial growth factor recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348d9d50b19c4984252883a6424aab40
https://pubmed.ncbi.nlm.nih.gov/22869152
https://pubmed.ncbi.nlm.nih.gov/22869152
Publikováno v:
The Journal of Cell Biology
Endocytosed Shiga toxin is transported from the Golgi complex to the endoplasmic reticulum in butyric acid-treated A431 cells. We here examine the extent of this retrograde transport and its regulation. The short B fragment of Shiga toxin is sufficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b4139134b7cf6a30e63dd2b750bbd1
https://doi.org/10.1083/jcb.126.1.53
https://doi.org/10.1083/jcb.126.1.53