Výsledky vyhledávání - "B. van Deurs"

Delivery into cells: lessons learned from plant and bacterial toxins

Publikováno v: Gene Therapy. 12:865-872

A number of protein toxins of bacterial and plant origin have cytosolic targets, and knowledge about these toxins have provided us with essential information about mechanisms that can be used to gain access to the cytosol as well as detailed knowledg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a394a9e0096d527dfc6bd869399938f4
https://doi.org/10.1038/sj.gt.3302525

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Molecules internalized by clathrin-independent endocytosis are delivered to endosomes containing transferrin receptors

Autor: Steen H. Hansen, B. van Deurs, Kirsten Sandvig

Publikováno v: The Journal of Cell Biology

We have previously demonstrated that the preendosomal compartment in addition to clathrin-coated vesicles, comprises distinct nonclathrin coated endocytic vesicles mediating clathrin-independent endocytosis (Hansen, S. H., K. Sandvig, and B. van Deur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68889ab00de844e5b976abbd375f129a
http://europepmc.org/articles/PMC2119820

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Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA

Autor: B. van Deurs, Tore Geir Iversen, Kirsten Sandvig, Grethe Skretting

Publikováno v: Proceedings of the National Academy of Sciences. 100:5175-5180

To investigate the role of clathrin in coated vesicle formation, a cell line with inducible expression of clathrin heavy chain (CHC) antisense RNA was produced. After 18 h of CHC antisense RNA expression, the internalization of transferrin was inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::916826faede9d48e6155f11f31e7b301
https://doi.org/10.1073/pnas.0534231100

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NEW EMBO MEMBERS' REVIEW: Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

Autor: B. van Deurs, K. Sandvig

Publikováno v: The EMBO Journal. 19:5943-5950

A large number of plant and bacterial toxins with enzymatic activity on intracellular targets are now known. These toxins enter cells by first binding to cell surface receptors, then they are endocytosed and finally they become translocated into the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c0c000c3cc93312a49e275c7ed087e
https://doi.org/10.1093/emboj/19.22.5943

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Ricin transport into cells: studies of endocytosis and intracellular transport

Autor: B. van Deurs, Stine Grimmer, K. Rodal, Maria Lyngaas Torgersen, Tore Geir Iversen, Paolo Nicoziani, Kirsten Sandvig

Publikováno v: ResearcherID

The plant toxin ricin binds to both glycoproteins and glycolipids with terminal galactose, and the toxin will therefore be endocytosed by the different mechanisms operating in a given cell. After endocytosis the toxin is transported to the Golgi appa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d4afa94ef54aedc51e8ddce4413dc2
https://doi.org/10.1016/s1438-4221(00)80055-7

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Endocytic mechanisms responsible for uptake of GPI-linked diphtheria toxin receptor

Autor: Maria Lyngaas Torgersen, Grethe Skretting, K. Sandvig, B. van Deurs

Publikováno v: ResearcherID

We have here used diphtheria toxin as a tool to investigate the type of endocytosis used by a glycosylphosphatidylinositol-linked molecule, a glycosylphosphatidylinositol-linked version of the diphtheria toxin receptor that is able to mediate intoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d29182bc1f162bd84133d3a3a18ff56
https://doi.org/10.1242/jcs.112.22.3899

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Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin

Autor: K. Sandvig, B. van Deurs

Publikováno v: Physiological Reviews. 76:949-966

Protein toxins such as ricin and Shiga toxin with intracellular targets have to be endocytosed and translocated to the cytosol to inhibit the protein synthesis and thereby kill the cell. Ricin is internalized by both clathrin-dependent and -independe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf3982d0e30d8f77560f214203d5702
https://doi.org/10.1152/physrev.1996.76.4.949

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Destabilization of plasma membrane structure by prevention of actin polymerization. Microtubule-dependent tubulation of the plasma membrane

Autor: F. A. von Bülow, P. K. Holm, Frederik Vilhardt, Kirsten Sandvig, B. van Deurs

Publikováno v: Europe PubMed Central

Electron microscopy of thick (0.2-1.0 micron) sections of cytochalasin D-treated cells fixed in the presence of Ruthenium red revealed an extensive, surface-connected tubular compartment in HEp-2 cells. The tubules measured 120–220 nm in diameter a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96600cef17b69ae6b347b1476095faf
https://doi.org/10.1242/jcs.109.7.1655

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A transferrin-like GPI-linked iron-binding protein in detergent-insoluble noncaveolar microdomains at the apical surface of fetal intestinal epithelial cells

Autor: E M Danielsen, B. van Deurs

Publikováno v: The Journal of Cell Biology

A GPI-anchored 80-kD protein was found to be the major component of detergent-insoluble complexes, prepared from fetal porcine small intestine, constituting about 25% of the total amount of protein. An antibody was raised to the 80-kD protein, and by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86092a23d5b0d023effe4c711138fb57
https://doi.org/10.1083/jcb.131.4.939

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