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Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization

Autor: Kacy S. Yount, Jesse M. Hall, Kyle Caution, Mohamed M. Shamseldin, Myra Guo, Keirsten Marion, Audra R. Fullen, Yimin Huang, Jennifer A. Maynard, Sally A. Quataert, Rajendar Deora, Purnima Dubey

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionResurgence of pertussis, caused by Bordetella pertussis, necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted acellular pertussis vaccines (aPV) delivered intramuscularly reduce bacterial numbers

Externí odkaz: https://doaj.org/article/a1e6ca1303d648f88b89574d55a62b06

Putting computational models of immunity to the test - an invited challenge to predict B. pertussis vaccination outcomes.

Autor: Shinde P; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Willemsen L; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Anderson M; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Aoki M; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Basu S; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Burel JG; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Cheng P; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Dastidar SG; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Dunleavy A; School of Statistics, University of Minnesota, Minneapolis, MN, USA., Einav T; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, San Diego, CA, USA., Forschmiedt J; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Fourati S; Department of Medicine, Division of Allergy and Immunology, Feinberg School of Medicine and Center for Human Immunobiology, Northwestern University, Chicago, IL, USA., Garcia J; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Gibson W; Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA., Greenbaum JA; LJI Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA, USA., Guan L; Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA., Guan W; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Gygi JP; Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT, USA., Ha B; LJI Bioinformatics Core, La Jolla Institute for Immunology, La Jolla, CA, USA., Hou J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hsiao J; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Huang Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Jansen R; Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Kakoty B; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Kang Z; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Kobie JJ; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA., Kojima M; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Konstorum A; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Laboratory for Systems Biology, University of Florida., Lee J; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Lewis SA; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Li A; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Lock EF; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Mahita J; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Mendes M; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Meng H; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Neher A; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Nili S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Olsen LR; University of Denmark, Denmark., Orfield S; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Overton JA; Knocean, Inc., Toronto, Canada., Pai N; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Parker C; National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD, USA., Qian B; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Rasmussen M; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Reyna J; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, San Diego, CA, USA., Richardson E; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Safo S; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Sorenson J; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Srinivasan A; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Thrupp N; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Tippalagama R; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA., Trevizani R; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Fundação Oswaldo Cruz, Fiocruz - Ceará, Brazil., Ventz S; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Wang J; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Wu CC; Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA., Ay F; Department of Medicine, University of California San Diego, San Diego, CA, USA.; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, USA., Grant B; Department of Molecular Biology, School of Biological Sciences, University of California, San Diego, La Jolla, CA, USA., Kleinstein SH; Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Peters B; Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA, USA.; Department of Medicine, University of California San Diego, San Diego, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.