Zobrazeno 1 - 10
of 29
pro vyhledávání: '"B. Yu. Lalaev"'
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 1, Pp 13-17 (2020)
Introduction. The chlorination reaction in the synthesis of the substance of bendamustine hydrochloride is a complex process. The presence of active adverse reactions makes scaling difficult.Aim. Improving the performance of the technology for produc
Externí odkaz:
https://doaj.org/article/645613e4a4dc469a83c06189f4d0d0f4
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 148-152 (2019)
The possibility and prospects of carrying out the chlorination step in the scheme for the synthesis of bendamustine hydrochloride were investigated. The advantages and prospects of the process in the flow microreactor are shown. The conditions for co
Externí odkaz:
https://doaj.org/article/8e66974da5ce43429750b834aae6c40d
Publikováno v:
Russian Journal of Organic Chemistry. 53:805-807
Reaction of 2,5-substituted 4-hydroxy-6Н-1,3-oxazin-6-ones with 2-hydrazinyl-1,3-benzothiazole in anhydrous polar solvent (methanol) without heating led to the formation of new derivatives of 1,2,4-thiazoles. Screening of biologic activity was perfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6956cddfffc6789c39d5da590e1fc9ce
https://doi.org/10.1134/s107042801705027x
https://doi.org/10.1134/s107042801705027x
Publikováno v:
Russian Journal of General Chemistry. 80:2043-2047
Reactions of 2-alkylsulfanyl- and 2-alkoxy-4-hydroxy-6H-1,3-oxazin-6-ones with oxygen-centered nucleophiles were studied. 2-Alkoxy-4-hydroxy-6H-1,3-oxazin-6-ones reacted with water and alcohols to give the corresponding alkyl 3-amino-3-oxopropanoates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41765803a726094f6befa9ed5b4a6939
https://doi.org/10.1134/s1070363210100269
https://doi.org/10.1134/s1070363210100269
Publikováno v:
Russian Journal of General Chemistry. 77:1100-1103
Aromatic and heteroaromatic acid hydrazides reacted with oxalyl chloride in benzene or chloroform to give previously unknown 2-aryl(hetaryl)-4H-1,3,4-oxadiazine-5,6-diones whose structure was confirmed by the NMR, IR, and mass spectra. According to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b14961987432bb0105618488e7f53fdc
https://doi.org/10.1134/s1070363207060266
https://doi.org/10.1134/s1070363207060266
Publikováno v:
Russian Journal of General Chemistry. 76:645-648
4-Hydroxy-6H-1,3oxazin-6-ones exhibit properties of weak OH acids. These compounds are readily methylated with diazomethane to give the corresponding 4-methoxy derivatives. According to the potentiometric titration data, the pKa values of 2-methoxy-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466bb4e8fc728f71f7c0d4dda5ceafd7
https://doi.org/10.1134/s1070363206040256
https://doi.org/10.1134/s1070363206040256
Publikováno v:
Russian Journal of General Chemistry. 75:432-436
Alkyl carbamates and S-alkyl thiocarbamates react with substituted malonyl dichlorides in boiling benzene to give the corresponding 2,5-substituted 4-hydroxy-6H-1,3-oxazin-6-ones. The reaction of S-methyl thiocarbamate with unsubstituted malonyl dich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf4261d2a4699f270e55ebec5146165
https://doi.org/10.1007/s11176-005-0245-7
https://doi.org/10.1007/s11176-005-0245-7
Publikováno v:
Russian Journal of Organic Chemistry. 52:605-606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8887bfb0906679b56883223d93a5714
https://doi.org/10.1134/s1070428016040278
https://doi.org/10.1134/s1070428016040278
Publikováno v:
Russian Journal of General Chemistry. 79:1583-1584
We previously reported on reactions of aromatic and heteroaromatic acid hydrazides with oxalyl chloride in boiling benzene, which afforded 80–90% of the corresponding 2-aryl(hetaryl)-4H-1,3,4-oxadiazine5,6-diones [1]. Analogous 4H-1,3,4-thiadiazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::216dd3b124927b84cb7ea87244824e95
https://doi.org/10.1134/s1070363209070263
https://doi.org/10.1134/s1070363209070263
Publikováno v:
Russian Journal of General Chemistry. 76:133-134
The reaction of methyl thiocarbamate with malonyl dichloride at low temperatures provides an N-substituted thiocarbamate, whereas prolonged boiling in high-boiling solvents gives rise to 4-hydroxy-2-(methylsulfanyl)-6H-1,3-oxazin-6-one that was also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f342d92fe890642233fb3538c237393a
https://doi.org/10.1134/s1070363206010257
https://doi.org/10.1134/s1070363206010257