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Autor: Ryan A. Flynn, Christopher M. Richards, Julien Couthouis, Wenjie Qiao, Aaron D. Gitler, Michael L Zhao, Joseph D. Puglisi, Christopher P. Lapointe, Alex G. Johnson, Yaw Shin Ooi, Jan E. Carette, Shizuka B. Yamada

In order to maintain cellular protein homeostasis, ribosomes are safeguarded against dysregulation by myriad processes. Remarkably, many cell types can withstand the genetic disruption of numerous ribosomal protein genes, indicating that select ribos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7845c59e1d686a448ada7c8a243769ba

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Autor: Shuying Sun, Steven Boeynaems, Gregor Bieri, Aaron D. Gitler, Nicholas J. Kramer, Shizuka B. Yamada, Joseph W. Paul, Wim Robberecht, Ludo Van Den Bosch, Joseph R. Herdy, Jerome Mertens, Fred H. Gage, Noori Chai, Ana Jovičić, Elke Bogaert

Publikováno v: Nature Neuroscience. 18:1226-1229

C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by unconventional translation of the C9orf72 repeat expansions cause neurodegeneration in

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https://doi.org/10.1038/nn.4085

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017

Autor: Lozano, R. Fullman, N. Abate, D. Abay, S.M. Abbafati, C. Abbasi, N. Abbastabar, H. Abd-Allah, F. Abdela, J. Abdelalim, A. Abdel-Rahman, O. Abdi, A. Abdollahpour, I. Abdulkader, R.S. Abebe, N.D. Abebe, Z. Abejie, A.N. Abera, S.F. Abil, O.Z. Aboyans, V. Abraha, H.N. Abrham, A.R. Abu-Raddad, L.J. Abu-Rmeileh, N.M. Abyu, G.Y. Accrombessi, M.M.K. Acharya, D. Acharya, P. Adamu, A.A. Adebayo, O.M. Adedeji, I.A. Adedoyin, R.A. Adekanmbi, V. Adetokunboh, O.O. Adhena, B.M. Adhikari, T.B. Adib, M.G. Adou, A.K. Adsuar, J.C. Afarideh, M. Afshari, M. Afshin, A. Agarwal, G. Aghayan, S.A. Agius, D. Agrawal, A. Agrawal, S. Ahmadi, A. Ahmadi, M. Ahmadieh, H. Ahmed, M.B. Ahmed, S. Akalu, T.Y. Akanda, A.S. Akbari, M.E. Akibu, M. Akinyemi, R.O. Akinyemiju, T. Akseer, N. Alahdab, F. Al-Aly, Z. Alam, K. Alam, T. Albujeer, A. Alebel, A. Alene, K.A. Al-Eyadhy, A. Alhabib, S. Ali, R. Alijanzadeh, M. Alizadeh-Navaei, R. Aljunid, S.M. Alkerwi, A. Alla, F. Allebeck, P. Allen, C.A. Almasi, A. Al-Maskari, F. 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Vujcic, I.S. Wagner, G.R. Wagnew, F.S. Waheed, Y. Walson, J.L. Wang, Y. Wang, Y.-P. Wassie, M.M. Weiderpass, E. Weintraub, R.G. Weiss, J. Weldegebreal, F. Weldegwergs, K.G. Werdecker, A. Werkneh, A.A. West, T.E. Westerman, R. Whisnant, J.L. Whiteford, H.A. Widecka, J. Widecka, K. Wijeratne, T. Wilner, L.B. Winkler, A.S. Wiyeh, A.B. Wiysonge, C.S. Wolde, H.F. Wolfe, C.D.A. Wu, S. Xavier, D. Xu, G. Xu, R. Yadollahpour, A. Jabbari, S.H.Y. Yakob, B. Yamada, T. Yan, L.L. Yano, Y. Yaseri, M. Yasin, Y.J. Ye, P. Yearwood, J.A. Yeshaneh, A. Yimer, E.M. Yip, P. Yirsaw, B.D. Yisma, E. Yonemoto, N. Yonga, G. Yoon, S.-J. Yotebieng, M. Younis, M.Z. Yousefifard, M. Yu, C. Zaman, S.B. Zamani, M. Zare, Z. Zavala-Arciniega, L. Zegeye, D.T. Zegeye, E.A. Zeleke, A.J. Zendehdel, K. Zerfu, T.A. Zhang, A.L. Zhang, X. Zhou, M. Zhu, J. Zimsen, S.R.M. Zodpey, S. Zoeckler, L. Zucker, I. Zuhlke, L.J.J. Lim, S.S. Murray, C.J.L. GBD 2017 SDG Collaborators

Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of “leavi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::71c882d52f41e20b9fc78dfee063540e
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3106846

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Autor: Michael P. Hart, J. Paul Taylor, Linh Pham, Bhavani Bagevalu Siddegowda, Donovan B. Lockwood, Daniela C. Zarnescu, Allen B. Reitz, Aaron D. Gitler, Shizuka B. Yamada, Alyssa N. Coyne, Brian D. Freibaum, Ashley Boehringer, Joel A. Cassel, Benjamin L. Zaepfel, Jeffrey Johannesmeyer, Patricia S. Estes

RNA dysregulation is a newly recognized disease mechanism in amyotrophic lateral sclerosis (ALS). Here we identify Drosophila fragile X mental retardation protein (dFMRP) as a robust genetic modifier of TDP-43-dependent toxicity in a Drosophila model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72f75429674723d6b32bcfe440988ba
https://europepmc.org/articles/PMC5007633/

Preliminary evidence of age-dependent clinical signs associated with porcine circovirus 2b in experimentally infected CH3/Rockefeller mice

Autor: Cinthia K. Mori, Sueli Santos, Leonardo José Richtzenhain, Katarina B. Yamada, C. P Oliveira, Priscilla F. Gerber, Taís F. Cruz, Michelle de Paula Gabardo, Alessandra Marnie Martins Gomes de Castro, Roberto Maurício Carvalho Guedes, João Pessoa Araújo

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2018-12-11T16:59:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-12-01 Mice and rats are susceptible to porcine circovirus 2b (PCV2) infection under field and experimental conditions. However, whether PCV2 induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4631abc62982881d7f5a733be518772