LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Autor: Fengyuan Tang, Ruize Gao, Beena Jeevan-Raj, Christof B. Wyss, Ravi K. R. Kalathur, Salvatore Piscuoglio, Charlotte K. Y. Ng, Sravanth K. Hindupur, Sandro Nuciforo, Eva Dazert, Thomas Bock, Shuang Song, David Buechel, Marco F. Morini, Alexander Hergovich, Patrick Matthias, Dae-Sik Lim, Luigi M. Terracciano, Markus H. Heim, Michael N. Hall, Gerhard Christofori

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor

Externí odkaz: https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Autor: Annah B. Wyss, Tamar Sofer, Mi Kyeong Lee, Natalie Terzikhan, Jennifer N. Nguyen, Lies Lahousse, Jeanne C. Latourelle, Albert Vernon Smith, Traci M. Bartz, Mary F. Feitosa, Wei Gao, Tarunveer S. Ahluwalia, Wenbo Tang, Christopher Oldmeadow, Qing Duan, Kim de Jong, Mary K. Wojczynski, Xin-Qun Wang, Raymond Noordam, Fernando Pires Hartwig, Victoria E. Jackson, Tianyuan Wang, Ma’en Obeidat, Brian D. Hobbs, Tianxiao Huan, Hongsheng Gui, Margaret M. Parker, Donglei Hu, Lauren S. Mogil, Gleb Kichaev, Jianping Jin, Mariaelisa Graff, Tamara B. Harris, Ravi Kalhan, Susan R. Heckbert, Lavinia Paternoster, Kristin M. Burkart, Yongmei Liu, Elizabeth G. Holliday, James G. Wilson, Judith M. Vonk, Jason L. Sanders, R. Graham Barr, Renée de Mutsert, Ana Maria Baptista Menezes, Hieab H. H. Adams, Maarten van den Berge, Roby Joehanes, Albert M. Levin, Jennifer Liberto, Lenore J. Launer, Alanna C. Morrison, Colleen M. Sitlani, Juan C. Celedón, Stephen B. Kritchevsky, Rodney J. Scott, Kaare Christensen, Jerome I. Rotter, Tobias N. Bonten, Fernando César Wehrmeister, Yohan Bossé, Shujie Xiao, Sam Oh, Nora Franceschini, Jennifer A. Brody, Robert C. Kaplan, Kurt Lohman, Mark McEvoy, Michael A. Province, Frits R. Rosendaal, Kent D. Taylor, David C. Nickle, L. Keoki Williams, Esteban G. Burchard, Heather E. Wheeler, Don D. Sin, Vilmundur Gudnason, Kari E. North, Myriam Fornage, Bruce M. Psaty, Richard H. Myers, George O’Connor, Torben Hansen, Cathy C. Laurie, Patricia A. Cassano, Joohon Sung, Woo Jin Kim, John R. Attia, Leslie Lange, H. Marike Boezen, Bharat Thyagarajan, Stephen S. Rich, Dennis O. Mook-Kanamori, Bernardo Lessa Horta, André G. Uitterlinden, Hae Kyung Im, Michael H. Cho, Guy G. Brusselle, Sina A. Gharib, Josée Dupuis, Ani Manichaikul, Stephanie J. London

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Pulmonary function is influenced by environmental factors, lifestyle, and genetics. Here, in a multiethnic GWAS meta-analysis for pulmonary function traits, the authors identify over 50 additional genetic loci, a subset of which are specific for Euro

Externí odkaz: https://doaj.org/article/b883c3b4b1074a7eaf40eb62c002409c

Data from Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis

Autor: Curzio Rüegg, Girieca Lorusso, Mauro Delorenzi, Pedro Romero, Oriana Coquoz, Amaïa Martinez Usatorre, David Barras, Sanam Peyvandi, Nathalie Duffey, Christof B. Wyss

Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management of metastatic disease remains unresolved. Brain metastasis is a late complication frequent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6629d3dd1430c1c4b657675623f320a5
https://doi.org/10.1158/0008-5472.c.6512320

Data from Single-Nucleotide Polymorphisms in Nucleotide Excision Repair Genes, Cigarette Smoking, and the Risk of Head and Neck Cancer

Autor: Andrew F. Olshan, William K. Funkhouser, Jill S. Barnholtz-Sloan, Jeannette T. Bensen, Mark C. Weissler, Christy L. Avery, Amy H. Herring, Annah B. Wyss

Background: Cigarette smoking is associated with increased head and neck cancer (HNC) risk. Tobacco-related carcinogens are known to cause bulky DNA adducts. Nucleotide excision repair (NER) genes encode enzymes that remove adducts and may be indepen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618510c53e0bba20ab494665e209a842
https://doi.org/10.1158/1055-9965.c.6515704.v1

Supplementary Figures from Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis

Autor: Curzio Rüegg, Girieca Lorusso, Mauro Delorenzi, Pedro Romero, Oriana Coquoz, Amaïa Martinez Usatorre, David Barras, Sanam Peyvandi, Nathalie Duffey, Christof B. Wyss

This file contains 6 supplementary figures and figure legends.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a98a57fb8bb90585b6acdd736d5e338
https://doi.org/10.1158/0008-5472.22426372