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Akademický článek

Inhaled treprostinil in patients with pulmonary hypertension associated with interstitial lung disease with less severe haemodynamics: a post hoc analysis of the INCREASE study

Autor: Steven D Nathan, Hilary M DuBrock, Victor F Tapson, Aaron B Waxman, Karim El-Kersh, Jason Weatherald, Eric Shen, Chunqin Deng, Steven J Cassady, Rahul G Argula, Franz P Rischard, James Tarver, Deborah J Levine, Manisit Das

Publikováno v: BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)

Background Inhaled treprostinil (iTre) is the only treatment approved for pulmonary hypertension due to interstitial lung disease (PH-ILD) to improve exercise capacity. This post hoc analysis evaluated clinical worsening and PH-ILD exacerbations from

Externí odkaz: https://doaj.org/article/32e10c17a26f434b9075064fb45b74c9

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Akademický článek

Perfusion imaging heterogeneity during NO inhalation distinguishes pulmonary arterial hypertension (PAH) from healthy subjects and has potential as an imaging biomarker

Autor: Tilo Winkler, Puja Kohli, Vanessa J. Kelly, Ekaterina G. Kehl, Alison S. Witkin, Josanna M. Rodriguez-Lopez, Kathryn A. Hibbert, Mamary T. Kone, David M. Systrom, Aaron B. Waxman, Jose G. Venegas, Richard N. Channick, R. Scott Harris

Publikováno v: Respiratory Research, Vol 23, Iss 1, Pp 1-16 (2022)

Abstract Background Without aggressive treatment, pulmonary arterial hypertension (PAH) has a 5-year mortality of approximately 40%. A patient’s response to vasodilators at diagnosis impacts the therapeutic options and prognosis. We hypothesized th

Externí odkaz: https://doaj.org/article/b72092f0ebae45b79c5c838832f9ffbc

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Akademický článek

Effects of ranolazine on right ventricular function, fluid dynamics, and metabolism in patients with precapillary pulmonary hypertension: insights from a longitudinal, randomized, double-blinded, placebo controlled, multicenter study

Autor: Q. Joyce Han, Paul Forfia, Anjali Vaidya, Gautam Ramani, Robert A. deKemp, Robert H. Mach, David A. Mankoff, Paco E. Bravo, Marcelo DiCarli, Stephen Y. Chan, Aaron B. Waxman, Yuchi Han

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 10 (2023)

IntroductionRight ventricular (RV) function is a major determinant of outcome in patients with precapillary pulmonary hypertension (PH). We studied the effect of ranolazine on RV function over 6 months using multi-modality imaging and biochemical mar

Externí odkaz: https://doaj.org/article/13928df1957a4d8594eaea5e39551deb

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Akademický článek

Recent advances in the management of pulmonary hypertension with interstitial lung disease

Autor: Aaron B. Waxman, Davide Elia, Yochai Adir, Marc Humbert, Sergio Harari

Publikováno v: European Respiratory Review, Vol 31, Iss 165 (2022)

Pulmonary hypertension (PH) is known to complicate various forms of interstitial lung disease (ILD), including idiopathic pulmonary fibrosis, the interstitial pneumonias and chronic hypersensitivity pneumonitis. Pathogenesis of PH-ILD remains incompl

Externí odkaz: https://doaj.org/article/8afe565912e340f2b4ead5e51317e274

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Akademický článek

Inspiratory flow patterns with dry powder inhalers of low and medium flow resistance in patients with pulmonary arterial hypertension

Autor: Mariana Faria-Urbina, Keith T. Ung, Laurie Lawler, Lawrence S. Zisman, Aaron B. Waxman

Publikováno v: Pulmonary Circulation, Vol 11 (2021)

Inhalation profiles to support use of dry powder inhalers for drug delivery in patients with pulmonary arterial hypertension have not been reported. We aimed to evaluate the inspiratory flow pattern associated with low and medium flow resistance dry

Externí odkaz: https://doaj.org/article/24712139141544aeabfa257bbfcab2be

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Akademický článek

Implantable system for treprostinil and lung transplantation: case series from delivery for pulmonary arterial hypertension study

Autor: Jeremy P. Feldman, Mardi Gomberg-Maitland, Shelley M. Shapiro, Amy A. Lautenbach, Marty Morris, Jeff A. Murphy, Aaron B. Waxman, Robert C. Bourge

Publikováno v: Pulmonary Circulation, Vol 11 (2021)

The implanted system for treprostinil has been described in previous publications. There is no information published about how to handle this system around lung or heart–lung transplantation. We present the experience from the DelIVery for Pulmonar

Externí odkaz: https://doaj.org/article/a1581cb080924aa99ff9d7e56d8838b8

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Akademický článek

Fick principle and exercise pulmonary hemodynamic determinants of the six-minute walk distance in pulmonary hypertension

Autor: Phillip Joseph, Rudolf K.F. Oliveira, Roza B. Eslam, Manyoo Agarwal, Aaron B. Waxman, David M. Systrom

Publikováno v: Pulmonary Circulation, Vol 10 (2020)

The six-minute walk test is widely used to assess the severity and prognosis of pulmonary hypertension. However, the pathophysiology underlying a compromised six-minute walk distance is incompletely characterized. The purpose of this study is to eval

Externí odkaz: https://doaj.org/article/b5cebe79812545c4b29254a9c55fc1e3

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