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Publikováno v:
Neuropsychopharmacology. 13:315-322
Four inhibitors of nitric oxide synthase (NOS), administered as acute pretreatments, attenuated several signs of naloxone-precipitated opioid withdrawal in morphine-dependent rats. Profiles of these drugs for inhibiting the expression of withdrawal w
Publikováno v:
The Journal of Immunology. 152:4671-4679
Infection of susceptible C57BL/6 mice with defective LP-BM5 murine leukemia virus causes disease termed murine acquired immune deficiency syndrome (MAIDS). The disease is characterized by lymphoadenopathy, hyperimmunoglobulinemia, and immune deficien
Autor:
D. B. Vaupel, Alane S. Kimes, Andrei O. Koren, and Alexey G. Mukhin, Edythe D. London, Andrew G. Horti, Svetlana I. Chefer, Olga A. Pavlova
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 44:S257-S259
Publikováno v:
physica status solidi (a). 117:K165-K169
Autor:
D. B. Vaupel, Andrei O. Koren, Edythe D. London, Alane S. Kimes, Andrew G. Horti, Alexey G. Mukhin
Publikováno v:
Neuroreport. 9(10)
5-[125I]iodo-3-(2(S)-azetidinylmethoxy)pyridine ([125I]5-I-A-85380) was evaluated in the mouse as a potential in vivo imaging ligand for central nicotinic acetylcholine receptors (nAChRs). After i.v. administration of [125I]5-I-A-85380, peak brain le
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 19(1)
Relationships between the spontaneous electroencephalogram (EEG), self-reports of cocaine craving, and cerebral glucose metabolism, determined using 2-[18F]fluoro-2-deoxy-D-glucose and positron emission tomography, were assessed during the presentati
Autor:
D B, Vaupel, D R, Jasinski
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 283(2)
l-alpha-Acetyl-N-normethadol (nor-LAAM) and l-alpha-acetyl-N, N-dinormethadol (dinor-LAAM) are active metabolites of the opiate l-alpha-acetylmethadol (LAAM), and they contribute to the prolonged actions of the parent compound. Single doses of nor-LA
Publikováno v:
NIDA research monograph. 147
The NOS inhibitors L-NARG and L-NAME attenuate weight loss and wet dog shakes, two specific signs of opioid withdrawal in rats. NMMA is more potent than L-NAME, consistent with the in vivo actions of these compounds as inhibitors of NOS. In addition,
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 267(3)
Organic calcium (Ca++) channel antagonists enhance opiate-induced analgesia and antagonize respiratory depression produced by morphine in rodents. Our preliminary data indicated that verapamil reduces the subjective effects of morphine in humans. We