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Dronedarone's Inhibition of If Current Is the Primary Mechanism Responsible for Its Bradycardic Effect

Autor: D B S Ananda Machado, Bruno B. Varone, Richard L. Verrier, Dewan Zeng, Bruce D. Nearing, F B S Lucas Sobrado, Luiz Belardinelli

Publikováno v: Journal of Cardiovascular Electrophysiology. 24:914-918

Dronedarone's Bradycardic Effect Introduction The mechanism(s) whereby dronedarone reduces sinus rate are not well understood, although L-type calcium channel antagonism, beta-adrenergic blockade, and inhibition of If are plausible. Methods and Resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2199fb8c95fd0131f00dcbba047c30a4
https://doi.org/10.1111/jce.12155

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An effective 3-fingered augmenting exoskeleton for the human hand

Autor: Martha H. Stella, Brett F. BuSha, B. Varone, C. J. Gearhart

Publikováno v: EMBC

Every year, thousands of Americans suffer from pathological and traumatic events that result in loss of dexterity and strength of the hand. Although many supportive devices have been designed to restore functional hand movement, most are very complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a975abd6961f7fa3d909187b7a6374c
https://doi.org/10.1109/embc.2016.7590771

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Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity

Autor: Bruce D. Nearing, Julio Americo Pereira Batatinha, Ana Flavia Garcia Silva, Bruno B. Varone, Rodolfo Bonatti, Ananda Dianni Machado, Lucas F. Sobrado, Richard L. Verrier, Luiz Belardinelli

Publikováno v: Heart rhythm. 11(10)

Ischemic heart disease is associated with dual risk for atrial and ventricular arrhythmias.We examined whether selectively targeting late sodium channel current (INa) with GS-458967 (hereafter GS967) can reduce cardiac electrical instability and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdcb33dd8bc63595a9a0b49deb040e5
https://pubmed.ncbi.nlm.nih.gov/24953379

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Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect

Autor: Lucas F, Sobrado, Bruno B, Varone, Ananda D, Machado, Bruce D, Nearing, Dewan, Zeng, Luiz, Belardinelli, Richard L, Verrier

Publikováno v: Journal of cardiovascular electrophysiology. 24(8)

The mechanism(s) whereby dronedarone reduces sinus rate are not well understood, although L-type calcium channel antagonism, beta-adrenergic blockade, and inhibition of If are plausible.In anesthetized pigs, we compared the effects of dronedarone to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::843ea95686deb2882419fe1e2aaf2d9f
https://pubmed.ncbi.nlm.nih.gov/23647933

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Response analysis of feed-forward neural network predictors

Autor: Jarno M. A. Tanskanen, B. Varone, Seppo J. Ovaska

Publikováno v: ICASSP
Scopus-Elsevier

We investigate the characteristics of some one-step-ahead nonlinear predictors based on a two-layer feed-forward neural network (2LFNN). The behavior of neural networks (NN) is investigated in the frequency domain using two frequency response estimat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c3a99e472ccab5f10d0caea34181ebc
https://doi.org/10.1109/icassp.1997.595501

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